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The American Journal of Tropical Medicine and Hygiene
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Clinical Intervention and Molecular Characteristics of a Dengue Hemorrhagic Fever Outbreak in Timor Leste, 2005

Siripen KalayanaroojQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Hem Sagar RimalQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Alex AndjaparidzeQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Varunee VatcharasaeveeQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Ananda NisalakQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Richard G. JarmanQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Piyawan ChinnawirotpisanQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Mammen P. MammenQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Edward C. HolmesQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Robert V. GibbonsQueen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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DOI:
https://doi.org/10.4269/ajtmh.2007.77.534
Volume/Issue:
Volume 77: Issue 3
Page(s):
534–537
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In response to a January 2005 report of dengue hemorrhagic fever (DHF) in Timor Leste, the World Health Organization sent a team to assist the National Hospital Guido Valadares (NHGV) in Dili with clinical case management and diagnostic support. The hospital reported 67 admissions including 8 deaths (case fatality rate approximately 12%) over the previous weeks with case histories clinically compatible with DHF. During the intervention, an additional 44 suspected dengue patients were admitted to the pediatric ward of NHGV. Among 41 patients with clinical diagnoses of dengue fever or DHF, 38 (93%) were laboratory confirmed. Although cause and effect cannot be definitely attributed, the case fatality rate decreased to 3.6% after the intervention with education about dengue management strategies.

Copyright:
Copyright 2007 The American Society of Tropical Medicine 2007
Received:
27 Nov 2006
|
Accepted:
02 Jun 2007
|
Published Online:
Sep 2007
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