Clinical Intervention and Molecular Characteristics of a Dengue Hemorrhagic Fever Outbreak in Timor Leste, 2005

Siripen Kalayanarooj Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Hem Sagar Rimal Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Alex Andjaparidze Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Varunee Vatcharasaevee Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Ananda Nisalak Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Richard G. Jarman Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Piyawan Chinnawirotpisan Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Mammen P. Mammen Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Edward C. Holmes Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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Robert V. Gibbons Queen Sirikit National Institute of Child Health, Bangkok, Thailand; National Hospital Guido Valadares, Dili, East Timor; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; World Health Organization, Dili, Timor Leste, Department of Biology, The Pennsylvania State University, University Park, Pennsylvania

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In response to a January 2005 report of dengue hemorrhagic fever (DHF) in Timor Leste, the World Health Organization sent a team to assist the National Hospital Guido Valadares (NHGV) in Dili with clinical case management and diagnostic support. The hospital reported 67 admissions including 8 deaths (case fatality rate approximately 12%) over the previous weeks with case histories clinically compatible with DHF. During the intervention, an additional 44 suspected dengue patients were admitted to the pediatric ward of NHGV. Among 41 patients with clinical diagnoses of dengue fever or DHF, 38 (93%) were laboratory confirmed. Although cause and effect cannot be definitely attributed, the case fatality rate decreased to 3.6% after the intervention with education about dengue management strategies.

  • 1

    Halstead SB, 2005. More dengue, more questions. Emerg Infect Dis 11 :740–741.

  • 2

    Peragallo MS, Nicoletti L, Lista F, D’Amelio R, 2003. Probable dengue virus infection among Italian troops, East Timor, 1999–2000. Emerg Infect Dis 9 :876–880.

    • Search Google Scholar
    • Export Citation
  • 3

    World Health Organization, 2000. Dengue/Dengue Haemorrhagic Fever Prevention and Control Programme in Indonesia. Dengue Bulletin 24. Geneva: World Health Organization.

  • 4

    Anonymous, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization.

  • 5

    Innis BL, Nisalak A, Nimmannitya S, Kusalerdchariya S, Chongswasdi V, Suntayakorn S, Puttisri P, Hoke CH Jr, 1989. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis co-circulate. Am J Trop Med Hyg 40 :418–427.

    • Search Google Scholar
    • Export Citation
  • 6

    Lanciotti RS, Calisher CH, Gubler DJ, Chang GJ, Vorndam AV, 1992. Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. J Clin Microbiol 30 :545–551.

    • Search Google Scholar
    • Export Citation
  • 7

    Klungthong C, Zhang C, Mammen MP Jr, Ubol S, Holmes EC, 2004. The molecular epidemiology of dengue virus serotype 4 in Bangkok, Thailand. Virology 329 :168–179.

    • Search Google Scholar
    • Export Citation
  • 8

    Zhang C, Mammen MP Jr, Chinnawirotpisan P, Klungthong C, Rodpradit P, Monkongdee P, Nimmannitya S, Kalayanarooj S, Holmes EC, 2005. Clade replacements in dengue virus serotypes 1 and 3 are associated with changing serotype prevalence. J Virol 79 :15123–15130.

    • Search Google Scholar
    • Export Citation
  • 9

    Swofford DL, 2003. PAUP* Phylogenetic Analysis Using Parsimony (*and Other Methods). Sunderland, MA: Sinauer Associates.

  • 10

    Kalayanarooj S, Nimmannitya S, 2004. Guidelines for DHF Case Management. Bangkok, Thailand: Bangkok Publisher.

  • 11

    World Health Organization, 1999. Guidelines for Treatment of Dengue Fever/Dengue Hemorrhagic Fever in Small Hospitals. New Delhi: World Health Organization, 1–29.

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