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Reference Manager
BibTeX
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-
1
Guyatt HL, Snow RW, 2001. Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa. Trans R Soc Trop Med Hyg 95 :569–576.
-
2
World Health Organization, 2003. Lives at Risk: Malaria in Pregnancy.www.who.int/features/2003/04b/en/print.html. Accessed 12 October 2006.
-
3
World Health Organization, 2004. A Strategic Framework for Malaria Prevention and Control during Pregnancy in the African Region. AFR/MAL/04/01. Brazzaville, Republic of the Congo: WHO Regional Office for Africa.
-
4
Shulman CE, Dorman EK, Cutts F, Kawuondo K, Bulmer JN, Peshu N, Marsh K, 1999. Intermittent sulphadoxine–pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet 353 :632–636.
-
5
Parise ME, Ayisi JG, Nahlen BL, Schultz LJ, Roberts JM, Misore A, Muga R, Oloo AJ, Steketee RW, 1998. Efficacy of sulfa-doxine–pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg 59 :813–822.
-
6
Schultz LJ, Steketee RW, Macheso A, Kazembe P, Chitsulo L, Wirima JJ, 1994. The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi. Am J Trop Med Hyg 51 :515–522.
-
7
Newman RD, Moran AC, Kayentao K, Kayentao K, Benga-De E, Yameogo M, Gaye O, Faye O, Lo Y, Moreira PM, Doumbo O, Parise ME, Steketee RW, 2006. Prevention of malaria during pregnancy in West Africa: policy change and the power of subregional action. Trop Med Int Health 11 :462–469.
-
8
Mbaye A, Richardson K, Balajo B, Dunyo S, Shulman C, Milligan P, Greenwood B, Walraven G, 2006. A randomized, placebo-controlled trial of intermittent preventive treatment with sulphadoxine–pyrimethamine in Gambian multigravidae. Trop Med Int Health 11 :992–1002.
-
9
Newman RD, Hailemariam A, Jimma D, Degifie A, Kebede D, Rietveld AE, Nahlen BL, Barnwell JW, Steketee RW, Parise ME, 2003. Burden of malaria during pregnancy in areas of stable and unstable transmission in Ethiopia during a nonepidemic year. J Infect Dis 187 :1765–1772.
-
10
Ministère de Santé, 2005. Traitement Intermittent Préventif contre le Paludisme chez la Femme Enceinte. Libreville, Gabon: Programme Nationale pour la Lutte contre le Paludisme.
-
11
Ramharter M, Wernsdorfer WH, Kremsner PG, 2004. In vitro activity of quinolines against Plasmodium falciparum in Gabon. Acta Trop 90 :55–60.
-
12
World Health Organization 2003–2007, UNAIDS/WHO Global HIV/AIDS Online Database. www.who.int/globalatlas. Accessed 12 October 2006.
-
13
Planche T, Krishna S, Kombila M, Engel K, Fucher JF, Ngou-Milama E, Kremsner PG, 2001. Comparison of methods for the rapid laboratory assessment of children with malaria. Am J Trop Med Hyg 65 :599–602.
-
14
Ramharter M, Grobusch MP, Kiessling G, Adegnika AA, Möller U, Agnandji ST, Kramer M, Schwarz N, Kun JF, Oyakhirome S, Issifou S, Borrmann S, Lell B, Mordmüller B, Kremsner PG, 2005. Clinical and parasitological characteristics of puerperal malaria. J Infect Dis 191 :1005–1009.
-
15
Challis K, Osman NB, Cotiro M, Nordahl G, Dgedge M, Bergstrom S, 2004. Impact of a double dose of sulphadoxine–pyrimethamine to reduce prevalence of pregnancy malaria in southern Mozambique. Trop Med Int Health 9 :1066–1073.
-
16
van Eijk AM, Ayisi JG, ter Kuile FO, Otieno JA, Misore AO, Odondi JO, Rosen DH, Kager PA, Steketee RW, Nahlen BL, 2004. Effectiveness of intermittent preventive treatment with sulphadoxine––pyrimethamine for control of malaria in pregnancy in western Kenya: a hospital-based study. Trop Med Int Health 9 :351–360.
-
17
Rogerson SJ, Chaluluka E, Kanjala M, Mkundika P, Mhango C, Molyneux ME, 2000. Intermittent sulfadoxine–pyrimethamine in pregnancy: effectiveness against malaria morbidity in Blantyre, Malawi, in 1997–99. Trans R Soc Trop Med Hyg 94 :549–553.
-
18
Sirima SB, Cotte AH, Konate A, Moran AC, Asamoa K, Bougouma EC, Diarra A, Ouedraogo A, Parise ME, Newman RD, 2006. Malaria prevention during pregnancy: assessing the disease burden one year after implementing a program of intermittent preventive treatment in Koupela District, Burkina Faso. Am J Trop Med Hyg 75 :205–211.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 461 | 404 | 13 |
| Full Text Views | 301 | 4 | 0 |
| PDF Downloads | 123 | 4 | 0 |
Malaria in Pregnancy Before and After the Implementation of a National IPTp Program in Gabon
Michael Ramharter
Michael Ramharter
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Katharina Schuster
Katharina Schuster
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Marielle K. Bouyou-Akotet
Marielle K. Bouyou-Akotet
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Ayola A. Adegnika
Ayola A. Adegnika
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Kristen Schmits
Kristen Schmits
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Ghyslain Mombo-Ngoma
Ghyslain Mombo-Ngoma
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Selidji T. Agnandji
Selidji T. Agnandji
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Johannes Nemeth
Johannes Nemeth
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Solange Nzenze Afène
Solange Nzenze Afène
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Saadou Issifou
Saadou Issifou
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Isabelle Ndombi Onnas
Isabelle Ndombi Onnas
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Maryvonne Kombila
Maryvonne Kombila
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Peter G. Kremsner
Peter G. Kremsner
Medical Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon; Institut Pasteur, Université de la Méditerranée, Marseille, France; Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Vienna, Austria; Institute for Tropical Medicine, Department for Parasitology, University of Tübingen, Tübingen, Germany; Département de Parasitologie, Mycologie, Médecine Tropicale, Université des Sciences de la Santé, Libreville, Gabon; Département de Maternité, Centre Hospitalier de Libreville, Libreville, Gabon
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Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine has recently been adopted by many African countries to reduce maternal and neonatal morbidity and mortality associated with malaria in pregnancy. We assessed the impact of a newly established national IPTp program on maternal and neonatal health in Gabon. Data on prevalence of maternal Plasmodium falciparum infection, anemia, premature birth, and birth weight were collected in cross-sectional surveys in urban and rural regions of Gabon before and after the implementation of IPTp in a total of 1403 women and their offspring. After introduction of IPTp, the prevalence of maternal Plasmodium falciparum infection decreased dramatically (risk ratio 0.16, P < 0.001). Whereas only a modest effect on the rate of anemia in pregnant women was observed, there was a marked benefit on the prevalence of low birth weight and premature birth for women adhering to national recommendations. These effects were most pronounced in primi- and secundigravid women.
Author Notes
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-
1
Guyatt HL, Snow RW, 2001. Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa. Trans R Soc Trop Med Hyg 95 :569–576.
-
2
World Health Organization, 2003. Lives at Risk: Malaria in Pregnancy.www.who.int/features/2003/04b/en/print.html. Accessed 12 October 2006.
-
3
World Health Organization, 2004. A Strategic Framework for Malaria Prevention and Control during Pregnancy in the African Region. AFR/MAL/04/01. Brazzaville, Republic of the Congo: WHO Regional Office for Africa.
-
4
Shulman CE, Dorman EK, Cutts F, Kawuondo K, Bulmer JN, Peshu N, Marsh K, 1999. Intermittent sulphadoxine–pyrimethamine to prevent severe anaemia secondary to malaria in pregnancy: a randomised placebo-controlled trial. Lancet 353 :632–636.
-
5
Parise ME, Ayisi JG, Nahlen BL, Schultz LJ, Roberts JM, Misore A, Muga R, Oloo AJ, Steketee RW, 1998. Efficacy of sulfa-doxine–pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg 59 :813–822.
-
6
Schultz LJ, Steketee RW, Macheso A, Kazembe P, Chitsulo L, Wirima JJ, 1994. The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi. Am J Trop Med Hyg 51 :515–522.
-
7
Newman RD, Moran AC, Kayentao K, Kayentao K, Benga-De E, Yameogo M, Gaye O, Faye O, Lo Y, Moreira PM, Doumbo O, Parise ME, Steketee RW, 2006. Prevention of malaria during pregnancy in West Africa: policy change and the power of subregional action. Trop Med Int Health 11 :462–469.
-
8
Mbaye A, Richardson K, Balajo B, Dunyo S, Shulman C, Milligan P, Greenwood B, Walraven G, 2006. A randomized, placebo-controlled trial of intermittent preventive treatment with sulphadoxine–pyrimethamine in Gambian multigravidae. Trop Med Int Health 11 :992–1002.
-
9
Newman RD, Hailemariam A, Jimma D, Degifie A, Kebede D, Rietveld AE, Nahlen BL, Barnwell JW, Steketee RW, Parise ME, 2003. Burden of malaria during pregnancy in areas of stable and unstable transmission in Ethiopia during a nonepidemic year. J Infect Dis 187 :1765–1772.
-
10
Ministère de Santé, 2005. Traitement Intermittent Préventif contre le Paludisme chez la Femme Enceinte. Libreville, Gabon: Programme Nationale pour la Lutte contre le Paludisme.
-
11
Ramharter M, Wernsdorfer WH, Kremsner PG, 2004. In vitro activity of quinolines against Plasmodium falciparum in Gabon. Acta Trop 90 :55–60.
-
12
World Health Organization 2003–2007, UNAIDS/WHO Global HIV/AIDS Online Database. www.who.int/globalatlas. Accessed 12 October 2006.
-
13
Planche T, Krishna S, Kombila M, Engel K, Fucher JF, Ngou-Milama E, Kremsner PG, 2001. Comparison of methods for the rapid laboratory assessment of children with malaria. Am J Trop Med Hyg 65 :599–602.
-
14
Ramharter M, Grobusch MP, Kiessling G, Adegnika AA, Möller U, Agnandji ST, Kramer M, Schwarz N, Kun JF, Oyakhirome S, Issifou S, Borrmann S, Lell B, Mordmüller B, Kremsner PG, 2005. Clinical and parasitological characteristics of puerperal malaria. J Infect Dis 191 :1005–1009.
-
15
Challis K, Osman NB, Cotiro M, Nordahl G, Dgedge M, Bergstrom S, 2004. Impact of a double dose of sulphadoxine–pyrimethamine to reduce prevalence of pregnancy malaria in southern Mozambique. Trop Med Int Health 9 :1066–1073.
-
16
van Eijk AM, Ayisi JG, ter Kuile FO, Otieno JA, Misore AO, Odondi JO, Rosen DH, Kager PA, Steketee RW, Nahlen BL, 2004. Effectiveness of intermittent preventive treatment with sulphadoxine––pyrimethamine for control of malaria in pregnancy in western Kenya: a hospital-based study. Trop Med Int Health 9 :351–360.
-
17
Rogerson SJ, Chaluluka E, Kanjala M, Mkundika P, Mhango C, Molyneux ME, 2000. Intermittent sulfadoxine–pyrimethamine in pregnancy: effectiveness against malaria morbidity in Blantyre, Malawi, in 1997–99. Trans R Soc Trop Med Hyg 94 :549–553.
-
18
Sirima SB, Cotte AH, Konate A, Moran AC, Asamoa K, Bougouma EC, Diarra A, Ouedraogo A, Parise ME, Newman RD, 2006. Malaria prevention during pregnancy: assessing the disease burden one year after implementing a program of intermittent preventive treatment in Koupela District, Burkina Faso. Am J Trop Med Hyg 75 :205–211.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 461 | 404 | 13 |
| Full Text Views | 301 | 4 | 0 |
| PDF Downloads | 123 | 4 | 0 |