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1
Haque R, Huston CD, Hughes M, Houpt E, Petri WA Jr, 2003. Amebiasis. N Engl J Med 348 :1565ā1573.
-
3
AristizaĢbal H, Acevedo J, Botero M, 1991. Fulminant amebic colitis. World J Surg 15 :216ā221.
-
4
Takahashi T, Gamboa-Dominguez A, Gomez-Mendez TJM, Remes JM, Rembis V, Martinez-Gonzalez D, Gutierrez-Saldivar J, Morales JC, Granados J, Sierra-Madero J, 1997. Fuminant amebic colitis. Analysis of 55 cases. Dis Colon Rectum 40 :1362ā1367.
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5
Mitarai S, Nagai H, Satoh K, Hebisawa A, Shishido H, 2001. Amebiasis in Japanese homosexual men with human immunodeficiency virus infection. Intern Med 40 :671ā675.
-
6
Salem HH, Abd Rabbo H, 1964. Clinical trials with dehydroemetine dihydrochloride in the treatment of acute amoebiasis. J Trop Med Hyg 67 :137ā141.
-
7
Di Perri G, Strosselli M, Rondanelli EG, 1989. Therapy of entamebiasis. J Chemother 1 :113ā122.
-
8
Anonymous, 2004. Drugs for parasitic infections. Med Lett Drugs Ther 46 :e1ā12.
-
9
Nair KG, Kothari NN, Sheth UK, 1974. Intravenous metronidazole in amoebic liver abscess. Lancet 1 :1238.
-
10
Calleja Bello M, Colin Abarranco M, 1979. Amebic liver abscess. Treatment with metronidazole by the intravenous route. Prensa Med Mex 44 :112ā114.
-
11
Satpathy BK, Acharya SK, Satpaphy S, 1988. Comparative study of intravenous metronidazole and intramuscular dehydroemetine in amoebic liver abscess. J Indian Med Assoc 86 :38ā40.
-
12
Mattila J, MaĢnnistoĢ PT, MaĢntylaĢ R, NykaĢnen S, Lamminsivu U, 1983. Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Antimicrob Agents Chemother 23 :721ā725.
-
13
Hitani A, Nakamura T, Ohtomo H, Nawa Y, Kimura M, 2006. Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan. J Infect Chemother 12 :277ā282.
-
14
Gall SA, Edmisten C, Vernon RP Jr, 1980. Intravenous metronidazole in the treatment of ruptured amebic liver abscess. South Med J 73 :1274ā1275.
-
15
Kovaleski T, Malangoni MA, Wheat LJ, 1981. Treatment of an amebic liver abscess with intravenous metronidazole. Arch Intern Med 141 :132ā134.
-
16
Chowcat NL, Wyllie JH, 1976. Intravenous metronidazole in amoebic enterocolitis. Lancet 2 :1143.
-
17
Collier J, Colhoun EM, Hill PL, 1981. A multicentre comparison of clindamycin and metronidazole in the treatment of anaerobic infections. Scand J Infect Dis Suppl 26 :96ā100.
-
18
Gall SA, Kohan AP, Ayers OM, Hughes CE, Addison WA, Hill GB, 1981. Intravenous metronidazole or clindamycin with tobramycin for therapy of pelvic infections. Obstet Gynecol 57 :51ā58.
-
19
Kim KH, Choi JW, Lee JY, Kim TD, Paek JH, Lee EJ, Oh HA, Kim JH, Jang BI, Kim TN, Chung MK, Lee HJ, Byun WM, 2005. Two cases of metronidazole-induced encephalopathy. Korean J Gastroenterol 45 :195ā200.
-
20
Kusumi RK, Plouffe JF, Wyatt RH, Fass RJ, 1980. Central nervous system toxicity associated with metronidazole therapy. Ann Intern Med 93 :59ā60.
-
21
Ahmed A, Loes DJ, Bressler EL, 1995. Reversible magnetic resonance imaging findings in metronidazole-induced encephalopathy. Neurology 45 :588ā589.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 95 | 95 | 20 |
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Experience with Intravenous Metronidazole to Treat Moderate-to-Severe Amebiasis in Japan
Mikio Kimura
Mikio Kimura
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan; Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; University of Miyazaki, Miyazaki, Japan
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Tetsuya Nakamura
Tetsuya Nakamura
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan; Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; University of Miyazaki, Miyazaki, Japan
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Yukifumi Nawa
Yukifumi Nawa
Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan; Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan; University of Miyazaki, Miyazaki, Japan
Search for other papers by Yukifumi Nawa in
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Twenty-eight cases of either intestinal amebiasis, amebic liver abscess, or both, most of which were of moderate-to-severe intensity, were treated with intravenous metronidazole, pioneered by the Research Group on Chemotherapy of Tropical Diseases, Japan. This study was not conducted as a formal clinical trial, and all patients either underwent colectomy for intestinal amebiasis, received oral metronidazole, or both. Despite these limitations, intravenous metronidazole was shown to be well tolerated and seemed to be very effective. This agent should be more widely recommended than previously thought for treating moderate-to-severe amebiasis, especially its intestinal form.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Haque R, Huston CD, Hughes M, Houpt E, Petri WA Jr, 2003. Amebiasis. N Engl J Med 348 :1565ā1573.
-
3
AristizaĢbal H, Acevedo J, Botero M, 1991. Fulminant amebic colitis. World J Surg 15 :216ā221.
-
4
Takahashi T, Gamboa-Dominguez A, Gomez-Mendez TJM, Remes JM, Rembis V, Martinez-Gonzalez D, Gutierrez-Saldivar J, Morales JC, Granados J, Sierra-Madero J, 1997. Fuminant amebic colitis. Analysis of 55 cases. Dis Colon Rectum 40 :1362ā1367.
-
5
Mitarai S, Nagai H, Satoh K, Hebisawa A, Shishido H, 2001. Amebiasis in Japanese homosexual men with human immunodeficiency virus infection. Intern Med 40 :671ā675.
-
6
Salem HH, Abd Rabbo H, 1964. Clinical trials with dehydroemetine dihydrochloride in the treatment of acute amoebiasis. J Trop Med Hyg 67 :137ā141.
-
7
Di Perri G, Strosselli M, Rondanelli EG, 1989. Therapy of entamebiasis. J Chemother 1 :113ā122.
-
8
Anonymous, 2004. Drugs for parasitic infections. Med Lett Drugs Ther 46 :e1ā12.
-
9
Nair KG, Kothari NN, Sheth UK, 1974. Intravenous metronidazole in amoebic liver abscess. Lancet 1 :1238.
-
10
Calleja Bello M, Colin Abarranco M, 1979. Amebic liver abscess. Treatment with metronidazole by the intravenous route. Prensa Med Mex 44 :112ā114.
-
11
Satpathy BK, Acharya SK, Satpaphy S, 1988. Comparative study of intravenous metronidazole and intramuscular dehydroemetine in amoebic liver abscess. J Indian Med Assoc 86 :38ā40.
-
12
Mattila J, MaĢnnistoĢ PT, MaĢntylaĢ R, NykaĢnen S, Lamminsivu U, 1983. Comparative pharmacokinetics of metronidazole and tinidazole as influenced by administration route. Antimicrob Agents Chemother 23 :721ā725.
-
13
Hitani A, Nakamura T, Ohtomo H, Nawa Y, Kimura M, 2006. Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan. J Infect Chemother 12 :277ā282.
-
14
Gall SA, Edmisten C, Vernon RP Jr, 1980. Intravenous metronidazole in the treatment of ruptured amebic liver abscess. South Med J 73 :1274ā1275.
-
15
Kovaleski T, Malangoni MA, Wheat LJ, 1981. Treatment of an amebic liver abscess with intravenous metronidazole. Arch Intern Med 141 :132ā134.
-
16
Chowcat NL, Wyllie JH, 1976. Intravenous metronidazole in amoebic enterocolitis. Lancet 2 :1143.
-
17
Collier J, Colhoun EM, Hill PL, 1981. A multicentre comparison of clindamycin and metronidazole in the treatment of anaerobic infections. Scand J Infect Dis Suppl 26 :96ā100.
-
18
Gall SA, Kohan AP, Ayers OM, Hughes CE, Addison WA, Hill GB, 1981. Intravenous metronidazole or clindamycin with tobramycin for therapy of pelvic infections. Obstet Gynecol 57 :51ā58.
-
19
Kim KH, Choi JW, Lee JY, Kim TD, Paek JH, Lee EJ, Oh HA, Kim JH, Jang BI, Kim TN, Chung MK, Lee HJ, Byun WM, 2005. Two cases of metronidazole-induced encephalopathy. Korean J Gastroenterol 45 :195ā200.
-
20
Kusumi RK, Plouffe JF, Wyatt RH, Fass RJ, 1980. Central nervous system toxicity associated with metronidazole therapy. Ann Intern Med 93 :59ā60.
-
21
Ahmed A, Loes DJ, Bressler EL, 1995. Reversible magnetic resonance imaging findings in metronidazole-induced encephalopathy. Neurology 45 :588ā589.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 95 | 95 | 20 |
| Full Text Views | 164 | 113 | 0 |
| PDF Downloads | 163 | 107 | 0 |