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Kala-Azar Outbreak in Libo Kemkem, Ethiopia: Epidemiologic and Parasitologic Assessment

Jorge AlvarDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Seife BashayeDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Daniel ArgawDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Israel CruzDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Pilar AparicioDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Askal KassaDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Giannos OrfanosDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Fernando ParreñoDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Olusegan BabaniyiDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Nigussu GudetaDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Carmen CañavateDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Caryn BernDepartment for the Control of Neglected Tropical Diseases (CDS/NTD/IDM), Leishmaniasis Control Program, World Health Organization, Geneva, Switzerland; Malaria and Other Vector Borne Diseases, Prevention and Control Program, Ministry of Health, Ethiopia; Disease Prevention and Control Programmes, World Health Organization, Ethiopia; WHO Collaborating Center for Leishmaniasis, National Center of Microbiology, Instituto de Salud Carlos III, Madrid, Spain; National Center of Tropical Medicine, Instituto de Salud Carlos III, Madrid, Spain; Health Center, Addis Zemen, Ethiopia; Greek Medical Council, Athens, Greece; Area de Salud 7, Madrid, Spain; World Health Organization, Ethiopia, Regional Health Bureau, Bahar-Dar, Amhara State, Ethiopia; Division of Parasitic Diseases, National Center for Zoonotic, Vector-Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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In May 2005, visceral leishmaniasis (VL) was recognized for the first time in Libo Kemkem, Ethiopia. In October 2005, a rapid assessment was conducted using data from 492 patients with VL treated in the district health center and a household survey of 584 residents of four villages. One subdistrict accounted for 71% of early cases, but the incidence and number of affected subdistricts increased progressively throughout 2004–2005. In household-based data, we identified 9 treated VL cases, 12 current untreated cases, and 19 deaths attributable to VL (cumulative incidence, 7%). Thirty percent of participants were leishmanin skin test positive (men, 34%; women, 26%; P = 0.06). VL was more common in men than women (9.7% versus 4.5%, P < 0.05), possibly reflecting male outdoor sleeping habits. Molecular typing in splenic aspirates showed L. infantum (six) and L. donovani (one). Local transmission resulted from multiple introductions, is now well established, and will be difficult to eradicate.

Author Notes

Reprint requests: Jorge Alvar, Department for the Control of Neglected Tropical Diseases, World Health Organization, 20 Avenue Appia, CH-1211Geneva 27, Switzerland. E-mail: alvarj@who.int.
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