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RefWorks
Reference Manager
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-
1
Makker RP, Mukhopadhyay S, Monga A, Monga A, Gupta AK, 2002. Plasmodium vivax malaria presenting with severe thrombocytopenia. Braz J Infect Dis 6 :263–265.
-
2
Ohtaka M, Ohyashiki K, Iwabuchi H, Iwabuchi A, Lin KY, Toyama K, 1993. A case of vivax malaria with thrombocytopenia suggesting immunological mechanisms. Rinsho Ketsueki 34 :490–492.
-
3
Yamaguchi S, Kubota T, Yamagishi T, Okamoto K, Izumi T, Takagda M, Kanou S, Suzuki M, Tsuchiya J, Naruse T, 1997. Severe thromobocytopenia suggesting immunological mechanisms in two cases of vivax malaria. Am J Hematol 56 :183–186.
-
4
Layla AM, Mandil AA, Bahnassy AA, Ahmed MA, 2002. Malaria: Hematological aspects. Ann Saudi Med 22 :372–377.
-
5
Aggarwal A, Rath S, Shashira J, 2005. Plasmodium vivax malaria presenting with severe thrombocytopenia. J Trop Pediatr 51 :120–121.
-
6
Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M, 2006. Anemia and thrombocytopenia in children with Plasmodium vivax malaria. J Trop Pediatr 52 :49–51.
-
7
Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M, Franco-Paredes C, 2005. Occurrence of thrombocytopenia in Plasmodium vivax malaria. Clin Infect Dis 41 :130–131.
-
8
Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A, 2005. Plasmodium vivax malaria. Emerg Inf Dis 11 :132–134.
-
9
Erhart LM, Yingyuen K, Chuanak N, Buathong N, Laoboonchai A, Scott Miller R, Meshnick SR, Gasser RA, Wongsrichanalai C, 2004. Hematologic and clinical indices of malaria in semi-immune population of western Thailand. Am J Trop Med Hyg 70 :8–14.
-
10
Inyang AL, Okpako DT, Essien EM, 1987. Platelet reactions after interaction with cultured Plasmodium falciparum infected erythrocytes. Br J Haematol 66 :375–378.
-
11
Grau GE, Piguet PF, Gretner D, Vesin C, Lambert PH, 1988. Immunopathology of thrombocytopenia in experimental malaria. Immun 65 :501–506.
-
12
Wellde BT, Johnson AJ, Williams JS, Sadun EH, 1972. Experimental infection with Plasmodium falciparum in Aotus monkeys. I. Parasitological, hematologic and serum biochemical determinations. Am J Trop Med Hyg 2 :260–271.
-
13
Horstmann RD, Dietrich M, Bienzle U, Rasche H, 1981. Malaria induced thrombocytopenia. Blut 42 :157–164.
-
14
James MA, Kakoma I, Ristic M, Cagnard M, 1985. Induction of protective immunity to Plasmodium falciparum in Saimiri sciureus monkeys with partially purified exoantigens. Infect Imm 49 :476–480.
-
15
Kakoma I, James MA, Whiteley HE, Montelegre F, Buese M, Fafjar-Whetstone CJ, Clabaugh GW, Baek BK, 1992. Platelet kinetics and other hematological profiles in experimental Plasmodium falciparum infection: a comparative study between Saimiri and Aotus monkeys. Korean J Parasit 30 :177–182.
-
16
Jones TR, Stroncek DF, Gozalo AS, Obaldia NIII, Andersen EM, Lucas C, Narum DL, Macill AJ, Sim BKL, Hoffman SL, 2002. Anemia in parasite and recombinant protein-immunized Aotus monkeys infected with Plasmodium falciparum. Am J Trop Med Hyg 66 :672–679.
-
17
Ma NS, Rossan RN, Kelley ST, Harper JS, Bedard MT, Jones TC, 1978. Banding patterns of the chromosomes of two new karyotypes of the owl monkey. J Med Primatol 7 :146–155.
-
18
Obaldia NIII, 1991. Detection of Klebsiella pneumoniae antibodies in Aotus l. lemurinus (Panamanian owl monkey) using an enzyme linked immunoassay (ELISA) test. Lab Anim 25 :133–141.
-
19
Cooper RD, 1994. Studies of a chloroquine-resistant strain of Plasmodium vivax from Papua New Guinea in Aotus and Anopheles farauti s.l. J Parasitol 5 :789–795.
-
20
Obaldia NIII, Rossan RN, Cooper RD, Kyle DE, Nuzum EO, Rieckmann KH, Shanks GD, 1997. WR238605, chloroquine and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys. Am J Trop Med Hyg 56 :508–510.
-
21
Earle WC, Perez M, 1932. Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17 :1124–1130.
-
22
Corvelo TC, Schneider H, Harada ML, 2002. ABO blood groups in the primate species of Cebidae from the Amazon region. J Med Primatol 31 :136–141.
-
23
Fajardo LF, 1979. The role of platelets in infections. I. Observations in human and murine malaria. Arch Pathol Lab Med 103 :131–134.
-
24
Mohanty D, Marwha N, Chosh K, Sharma S, Garewal G, Shah S, Devi S, Das KC, 1988. Functional and ultrastructural changes of platelets in malarial infection. Trans R Soc Trop Med Hyg 82 :369–375.
-
25
Touze JE, Mercier P, Rogier C, Hovette P, Schmoor P, Dabanian C, Campiadgi S, Laroche R, 1990. Platelet antibody activity in malaria thrombocytopenia. Pathol Biol 38 :678–681.
-
26
Arnab P, Fergunson DJP, Kai O, Urban BC, Lowe B, Marsh K, Roberts D, 2001. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc Natl Acad Sci USA 98 :1805–1810.
-
27
Srichaikul T, Pulket C, Siristepisarn T, Prayoonwiwat W, 1988. Platelet dysfunction in malaria. Southeast Asian J Trop Med Public Health 19 :225–233.
-
28
Miao WM, Vasile E, Lane WS, Lawler J, 2001. CD36 associates with CD9 and integrins on human blood platelets. Blood 97 :1689–1696.
-
29
Erel O, Vural H, Aksoy N, Aslan G, Ulukanligil M, 2001. Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria. Clin Biochem 34 :341–344.
-
30
White NJ, 1998. Malaria pathophysiology. In: Sherman IW, ed. Malaria: Parasite Biology, Pathogenesis, and Protection. Washington, DC: American Society of Microbiology; 371–385.
-
31
Ockenshouse CF, Tandon NN, Magowan C, Jamieson GA, Chulay JD, 1989. Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor. Science 246 :1051.
-
32
Tomer A, 2004. Human marrow megakaryocytes differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes. Blood 104 :2722–2727.
-
33
Polack B, Peyron F, Sheick Zadiuddin I, Kolodie L, Ambroise-Thomas P, 1990. Erythrocytes infected by Plasmodium falciparum activate human platelets. C R Acad Sci III 310 :577–582.
-
34
Udomsanpetch R, Thanikkul K, Pukrittayakamee S, White NJ, 1995. Rosette formation by Plasmodium vivax. Trans R Soc Trop Med Hyg 89 :635–637.
-
35
Pallavicini F, Antinori A, Federico G, Maiuro G, Mencarini P, Tamburrini E, 1991. Influence of two antimalarials, chloroquine and mefloquine, on human myelopoiesis in vitro. Trans R Soc Trop Med Hyg 85 :42–43.
-
36
Gordon HR, 1994. Aplastic anemia during malarial prophylaxis with mefloquine. Clin Infect Dis 18 :263–264.
-
37
Stracher AR, Stoeckle MY, Giordano MF, 1994. Aplastic anemia during malarial prophylaxis with mefloquine. Clin Infect Dis 18 :263–264.
-
38
Wickramasinghe SN, Litwinczuck RA, 1981. Effects of low concentrations of pyrimethamine on human bone marrow cells in vitro: posible implications for malaria prophylaxis. J Trop Med Hyg 84 :233–238.
-
39
Rudin W, Quesniaux V, Favre N, Bordmann G, 1997. Malaria toxins: from P. chabaudi chabaudi AS and P. berghei ANKA cause dyserythropoiesis in C57BL/6 mice. Parasitology 115 :467–474.
-
40
Bordmann G, Favre N, Rudin W, 1997. Malaria toxins: effects on murine spleen and bone marrow cell proliferation and cytokine production in vitro. Parasitology 115 :475–483.
-
41
Wickramasinghe SN, Abdalla SH, 2000. Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol 13 :277–299.
-
42
McDevitt MA, Xie J, Gordeuk V, Bucala R, 2004. The anemia of malaria infection: role of inflammatory cytokines. Curr Hematol Rep 3 :97–106.
-
43
Jootar S, Chaisiripoomkere W, Pholvicha P, Leerlasiri A, Prayoonwiwat W, Mongkonsvitragoon W, Srichaikul T, 1993. Suppression of erythroid progenitor cells during malarial infection in Thai adults caused by serum inhibitor. Clin Lab Haematol 15 :87–92.
-
44
Kurtzhals JA, Rodrigues O, Addae M, Commey JO, Nkrumah FK, Hviid L, 1997. Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria. Br J Haematol 97 :169–174.
-
45
Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R, Winkler S, Pabinger I, Kletter K, 2004. Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemos 91 :553–557.
-
46
Egan AF, Fabucci ME, Saul A, Kaslow DC, Miller LH, 2002. Aotus New World monkeys: model for studying malaria-induced anemia. Blood 99 :3863–3866.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 453 | 402 | 71 |
| Full Text Views | 119 | 13 | 0 |
| PDF Downloads | 45 | 10 | 0 |
Clinico-Pathological Observations on the Pathogenesis of Severe Thrombocytopenia and Anemia Induced by Plasmodium vivax Infections During Antimalarial Drug Efficacy Trials in Aotus Monkeys
Nicanor Obaldía III
Nicanor Obaldía III
Malaria Drug and Vaccine Evaluation Center, Tropical Medicine Research, Panama City, Republic of Panama; Gorgas Memorial Institute of Health Studies (ICGES), Panama City, Republic of Panama
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During routine antimalarial drug efficacy trials, we observed, for the first time, severe thrombocytopenia developing in Aotus monkeys infected with Plasmodium vivax. Data obtained from 26 Aotus infected with the AMRU-1 strain showed that 77% developed severe thrombocytopenia, whereas only 15% had severe anemia, with hemorrhagic diathesis ensuing in 31%. In general, thrombocytopenic monkeys either failed primary treatment with experimental antimalarial drugs or were found to have higher-density parasitemias, longer patency duration, and lower hematocrits. In these monkeys, severe thrombocytopenia inversely correlated to parasitemia (R = −1.0), and animals that received a blood transfusion had significantly higher platelet counts (P < 0.05) by day 38 after inoculation. In conclusion, the AMRU-1 strain of P. vivax, was considered to be highly pathogenic to Aotus monkeys, and thrombocytopenia rather than anemia should be regarded an early indicator of drug treatment failure with this strain.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Makker RP, Mukhopadhyay S, Monga A, Monga A, Gupta AK, 2002. Plasmodium vivax malaria presenting with severe thrombocytopenia. Braz J Infect Dis 6 :263–265.
-
2
Ohtaka M, Ohyashiki K, Iwabuchi H, Iwabuchi A, Lin KY, Toyama K, 1993. A case of vivax malaria with thrombocytopenia suggesting immunological mechanisms. Rinsho Ketsueki 34 :490–492.
-
3
Yamaguchi S, Kubota T, Yamagishi T, Okamoto K, Izumi T, Takagda M, Kanou S, Suzuki M, Tsuchiya J, Naruse T, 1997. Severe thromobocytopenia suggesting immunological mechanisms in two cases of vivax malaria. Am J Hematol 56 :183–186.
-
4
Layla AM, Mandil AA, Bahnassy AA, Ahmed MA, 2002. Malaria: Hematological aspects. Ann Saudi Med 22 :372–377.
-
5
Aggarwal A, Rath S, Shashira J, 2005. Plasmodium vivax malaria presenting with severe thrombocytopenia. J Trop Pediatr 51 :120–121.
-
6
Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M, 2006. Anemia and thrombocytopenia in children with Plasmodium vivax malaria. J Trop Pediatr 52 :49–51.
-
7
Rodriguez-Morales AJ, Sanchez E, Vargas M, Piccolo C, Colina R, Arria M, Franco-Paredes C, 2005. Occurrence of thrombocytopenia in Plasmodium vivax malaria. Clin Infect Dis 41 :130–131.
-
8
Kochar DK, Saxena V, Singh N, Kochar SK, Kumar SV, Das A, 2005. Plasmodium vivax malaria. Emerg Inf Dis 11 :132–134.
-
9
Erhart LM, Yingyuen K, Chuanak N, Buathong N, Laoboonchai A, Scott Miller R, Meshnick SR, Gasser RA, Wongsrichanalai C, 2004. Hematologic and clinical indices of malaria in semi-immune population of western Thailand. Am J Trop Med Hyg 70 :8–14.
-
10
Inyang AL, Okpako DT, Essien EM, 1987. Platelet reactions after interaction with cultured Plasmodium falciparum infected erythrocytes. Br J Haematol 66 :375–378.
-
11
Grau GE, Piguet PF, Gretner D, Vesin C, Lambert PH, 1988. Immunopathology of thrombocytopenia in experimental malaria. Immun 65 :501–506.
-
12
Wellde BT, Johnson AJ, Williams JS, Sadun EH, 1972. Experimental infection with Plasmodium falciparum in Aotus monkeys. I. Parasitological, hematologic and serum biochemical determinations. Am J Trop Med Hyg 2 :260–271.
-
13
Horstmann RD, Dietrich M, Bienzle U, Rasche H, 1981. Malaria induced thrombocytopenia. Blut 42 :157–164.
-
14
James MA, Kakoma I, Ristic M, Cagnard M, 1985. Induction of protective immunity to Plasmodium falciparum in Saimiri sciureus monkeys with partially purified exoantigens. Infect Imm 49 :476–480.
-
15
Kakoma I, James MA, Whiteley HE, Montelegre F, Buese M, Fafjar-Whetstone CJ, Clabaugh GW, Baek BK, 1992. Platelet kinetics and other hematological profiles in experimental Plasmodium falciparum infection: a comparative study between Saimiri and Aotus monkeys. Korean J Parasit 30 :177–182.
-
16
Jones TR, Stroncek DF, Gozalo AS, Obaldia NIII, Andersen EM, Lucas C, Narum DL, Macill AJ, Sim BKL, Hoffman SL, 2002. Anemia in parasite and recombinant protein-immunized Aotus monkeys infected with Plasmodium falciparum. Am J Trop Med Hyg 66 :672–679.
-
17
Ma NS, Rossan RN, Kelley ST, Harper JS, Bedard MT, Jones TC, 1978. Banding patterns of the chromosomes of two new karyotypes of the owl monkey. J Med Primatol 7 :146–155.
-
18
Obaldia NIII, 1991. Detection of Klebsiella pneumoniae antibodies in Aotus l. lemurinus (Panamanian owl monkey) using an enzyme linked immunoassay (ELISA) test. Lab Anim 25 :133–141.
-
19
Cooper RD, 1994. Studies of a chloroquine-resistant strain of Plasmodium vivax from Papua New Guinea in Aotus and Anopheles farauti s.l. J Parasitol 5 :789–795.
-
20
Obaldia NIII, Rossan RN, Cooper RD, Kyle DE, Nuzum EO, Rieckmann KH, Shanks GD, 1997. WR238605, chloroquine and their combinations as blood schizonticides against a chloroquine-resistant strain of Plasmodium vivax in Aotus monkeys. Am J Trop Med Hyg 56 :508–510.
-
21
Earle WC, Perez M, 1932. Enumeration of parasites in the blood of malarial patients. J Lab Clin Med 17 :1124–1130.
-
22
Corvelo TC, Schneider H, Harada ML, 2002. ABO blood groups in the primate species of Cebidae from the Amazon region. J Med Primatol 31 :136–141.
-
23
Fajardo LF, 1979. The role of platelets in infections. I. Observations in human and murine malaria. Arch Pathol Lab Med 103 :131–134.
-
24
Mohanty D, Marwha N, Chosh K, Sharma S, Garewal G, Shah S, Devi S, Das KC, 1988. Functional and ultrastructural changes of platelets in malarial infection. Trans R Soc Trop Med Hyg 82 :369–375.
-
25
Touze JE, Mercier P, Rogier C, Hovette P, Schmoor P, Dabanian C, Campiadgi S, Laroche R, 1990. Platelet antibody activity in malaria thrombocytopenia. Pathol Biol 38 :678–681.
-
26
Arnab P, Fergunson DJP, Kai O, Urban BC, Lowe B, Marsh K, Roberts D, 2001. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc Natl Acad Sci USA 98 :1805–1810.
-
27
Srichaikul T, Pulket C, Siristepisarn T, Prayoonwiwat W, 1988. Platelet dysfunction in malaria. Southeast Asian J Trop Med Public Health 19 :225–233.
-
28
Miao WM, Vasile E, Lane WS, Lawler J, 2001. CD36 associates with CD9 and integrins on human blood platelets. Blood 97 :1689–1696.
-
29
Erel O, Vural H, Aksoy N, Aslan G, Ulukanligil M, 2001. Oxidative stress of platelets and thrombocytopenia in patients with vivax malaria. Clin Biochem 34 :341–344.
-
30
White NJ, 1998. Malaria pathophysiology. In: Sherman IW, ed. Malaria: Parasite Biology, Pathogenesis, and Protection. Washington, DC: American Society of Microbiology; 371–385.
-
31
Ockenshouse CF, Tandon NN, Magowan C, Jamieson GA, Chulay JD, 1989. Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor. Science 246 :1051.
-
32
Tomer A, 2004. Human marrow megakaryocytes differentiation: multiparameter correlative analysis identifies von Willebrand factor as a sensitive and distinctive marker for early (2N and 4N) megakaryocytes. Blood 104 :2722–2727.
-
33
Polack B, Peyron F, Sheick Zadiuddin I, Kolodie L, Ambroise-Thomas P, 1990. Erythrocytes infected by Plasmodium falciparum activate human platelets. C R Acad Sci III 310 :577–582.
-
34
Udomsanpetch R, Thanikkul K, Pukrittayakamee S, White NJ, 1995. Rosette formation by Plasmodium vivax. Trans R Soc Trop Med Hyg 89 :635–637.
-
35
Pallavicini F, Antinori A, Federico G, Maiuro G, Mencarini P, Tamburrini E, 1991. Influence of two antimalarials, chloroquine and mefloquine, on human myelopoiesis in vitro. Trans R Soc Trop Med Hyg 85 :42–43.
-
36
Gordon HR, 1994. Aplastic anemia during malarial prophylaxis with mefloquine. Clin Infect Dis 18 :263–264.
-
37
Stracher AR, Stoeckle MY, Giordano MF, 1994. Aplastic anemia during malarial prophylaxis with mefloquine. Clin Infect Dis 18 :263–264.
-
38
Wickramasinghe SN, Litwinczuck RA, 1981. Effects of low concentrations of pyrimethamine on human bone marrow cells in vitro: posible implications for malaria prophylaxis. J Trop Med Hyg 84 :233–238.
-
39
Rudin W, Quesniaux V, Favre N, Bordmann G, 1997. Malaria toxins: from P. chabaudi chabaudi AS and P. berghei ANKA cause dyserythropoiesis in C57BL/6 mice. Parasitology 115 :467–474.
-
40
Bordmann G, Favre N, Rudin W, 1997. Malaria toxins: effects on murine spleen and bone marrow cell proliferation and cytokine production in vitro. Parasitology 115 :475–483.
-
41
Wickramasinghe SN, Abdalla SH, 2000. Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol 13 :277–299.
-
42
McDevitt MA, Xie J, Gordeuk V, Bucala R, 2004. The anemia of malaria infection: role of inflammatory cytokines. Curr Hematol Rep 3 :97–106.
-
43
Jootar S, Chaisiripoomkere W, Pholvicha P, Leerlasiri A, Prayoonwiwat W, Mongkonsvitragoon W, Srichaikul T, 1993. Suppression of erythroid progenitor cells during malarial infection in Thai adults caused by serum inhibitor. Clin Lab Haematol 15 :87–92.
-
44
Kurtzhals JA, Rodrigues O, Addae M, Commey JO, Nkrumah FK, Hviid L, 1997. Reversible suppression of bone marrow response to erythropoietin in Plasmodium falciparum malaria. Br J Haematol 97 :169–174.
-
45
Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R, Winkler S, Pabinger I, Kletter K, 2004. Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemos 91 :553–557.
-
46
Egan AF, Fabucci ME, Saul A, Kaslow DC, Miller LH, 2002. Aotus New World monkeys: model for studying malaria-induced anemia. Blood 99 :3863–3866.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 453 | 402 | 71 |
| Full Text Views | 119 | 13 | 0 |
| PDF Downloads | 45 | 10 | 0 |