• 1

    Centers for Disease Control, 2006. Malaria Surveillance—United States, 2004. MMWR Morb Mortal Wkly Rep 55 :23–37.

  • 2

    Volmink J, Garner P, 2006. Directly observed therapy for treating tuberculosis. Cochrane Database Syst Rev :CD003343.

  • 3

    Greenwood B, 2006. Review: Intermittent preventive treatment: a new approach to the prevention of malaria in children in areas with seasonal malaria transmission. Trop Med Int Health 11 :983–991.

    • Search Google Scholar
    • Export Citation
  • 4

    Dondorp AM, Newton PN, Mayxay M, Van Damme W, Smithuis FM, Yeung S, Petit A, Lynam AJ, Johnson A, Hien TT, McGready R, Farrar JJ, Looareesuwan S, Day NP, Green MD, White NJ, 2004. Fake antimalarials in southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials. Trop Med Int Health 9 :1241–1246.

    • Search Google Scholar
    • Export Citation
  • 5

    Shanks GD, Ragama BO, Oloo AJ, 1999. Time to reappearance of malaria parasites following various drug treatment regimens in a holoendemic area of western Kenya. Trans R Soc Trop Med Hyg 93 :304–305.

    • Search Google Scholar
    • Export Citation
  • 6

    Edstein MD, Kotecka BM, Anderson KL, Pombo DJ, Kyle DE, Rieckmann KH, Good MF, 2005. Lengthy antimalarial activity of atovaquone in human plasma following atovaquone-proguanil administration. Antimicrob Agents Chemother 49 :4421–4422.

    • Search Google Scholar
    • Export Citation
  • 7

    Butcher GA, Sinden RE, 2003. Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro. Am J Trop Med Hyg 68 :111–114.

    • Search Google Scholar
    • Export Citation
  • 8

    Shanks GD, Oloo AJ, Aleman GM, Ohrt C, Klotz FW, Braitman D, Horton J, Brueckner R, 2001. A new primaquine analogue, tafenoquine (WR 238605), for prophylaxis against Plasmodium falciparum malaria. Clin Infect Dis 33 :1968–1974.

    • Search Google Scholar
    • Export Citation
  • 9

    Walsh DS, Eamsila C, Sasiprapha T, Sangkharomya S, Khaewsathien P, Supakalin P, Tang DB, Jarasrumgsichol P, Cherdchu C, Edstein MD, Rieckmann KH, Brewer TG, 2004. Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malaria. J Infect Dis 190 :1456–1463.

    • Search Google Scholar
    • Export Citation
  • 10

    Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF, 2005. Piperaquine: a resurgent antimalarial drug. Drugs 65 :75–87.

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

Drug-Free Holidays: Pre-Travel versus During Travel Malaria Chemoprophylaxis

View More View Less
  • 1 Army Malaria Institute, Brisbane, Queensland, Australia; Walter Reed Army Institute of Research, Silver Spring, Maryland; University of Alabama at Birmingham, Birmingham, Alabama; The Toronto Hospital, Toronto, Ontario, Canada; London School of Hygiene and Tropical Medicine, London, United Kingdom; World Health Organization Collaborating Centre for Travelers’ Health, University of Zurich, Zurich, Switzerland
Restricted access

Although efficacious forms of malaria chemoprophylaxis currently exist, many travelers to malaria-endemic areas fail to use them effectively. We suggest that taking antimalarial medications prior to travel may prevent more malaria by improving compliance. Treatment regimens of antimalarial drugs taken prior to travel could protect persons for up to one month of exposure. We urge additional testing of pre-travel malaria chemoprophylaxis regimens.

Save