17β-ESTRADIOL INCREASES LEISHMANIA MEXICANA KILLING IN MACROPHAGES FROM DBA/2 MICE BY ENHANCING PRODUCTION OF NITRIC OXIDE BUT NOT PRO-INFLAMMATORY CYTOKINES

C.M. LEZAMA-DÁVILA Department of Microbiology, The Ohio State University, Columbus, Ohio; Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México

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A.P. ISAAC-MÁRQUEZ Department of Microbiology, The Ohio State University, Columbus, Ohio; Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México

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J. BARBI Department of Microbiology, The Ohio State University, Columbus, Ohio; Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México

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S. OGHUMU Department of Microbiology, The Ohio State University, Columbus, Ohio; Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México

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A.R. SATOSKAR Department of Microbiology, The Ohio State University, Columbus, Ohio; Dirección de Estudios de Postgrado e Investigación, Universidad Autónoma de Campeche, México

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We have previously shown that female DBA/2 mice are significantly more resistant to Leishmania mexicana compared with males. Here, we have analyzed the effect of 17β-estradiol (E2) on function and cytokine production in male and female DBA/2 macrophages in vitro. We show that E2 increases NO production and parasite killing in L. mexicana-infected male and female DBA/2 macrophages without increasing production of pro-inflammatory cytokines. These data indicate that E2 may enhance leishmanicidal activity in macrophages by directly regulating production of NO.

Author Notes

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