IN VITRO SUSCEPTIBILITY OF P. FALCIPARUM POPULATIONS FROM COLOMBIA AND TANZANIA TO A NEW SYNTHETIC PEROXIDE (OZ277)

LYDA OSORIO International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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CLARIBEL MURILLO International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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SAMANDA APONTE International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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VALERIANA MAYAGAYA International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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CHRISTIAN SCHEURER International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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RETO BRUN International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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HUGUES MATILE International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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SERGIO WITTLIN International Center for Medical Research and Training (CIDEIM), Cali, Colombia; Ifakara Health Research & Development, Ifakara, Tanzania; Swiss Tropical Institute (STI), Basel, Switzerland; F. Hoffmann-La Roche Ltd., Basel, Switzerland

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Sensitivity of Plasmodium falciparum populations from Colombia (N = 38) and Tanzania (N = 45) to the newly developed, fully synthetic peroxide OZ277 was investigated using a standard isotopic microtest. OZ277 showed excellent activity against chloroquine-resistant isolates in Colombia with median IC50 [range] values of 2.5 ng/mL [0.34–8] (4.4 nM [0.6–14]) and Tanzania with 1.5 ng/mL [0.22–10] (2.65 nM [0.4–17.7]). The potency of OZ277 was similar to artesunate, showing median IC50 values of 1.5 ng/mL [0.42–8.6] (3.8 nM [1.1–22.3]) and 1.8 ng/mL [0.2–10] (4.7 nM [0.5–26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound.

Author Notes

Reprint requests: Lyda Osorio, CIDEIM Avenida 1 Norte #3-03 Cali, Colombia.
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