FALCIPARUM MALARIA WITH HEMOPHAGOCYTIC SYNDROME

KENJI OHNISHI Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Search for other papers by KENJI OHNISHI in
Current site
Google Scholar
PubMed
Close
,
KEIKO MITSUI Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Search for other papers by KEIKO MITSUI in
Current site
Google Scholar
PubMed
Close
,
NOBUHIRO KOMIYA Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Search for other papers by NOBUHIRO KOMIYA in
Current site
Google Scholar
PubMed
Close
,
NORIAKI IWASAKI Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Search for other papers by NORIAKI IWASAKI in
Current site
Google Scholar
PubMed
Close
,
AKIKO AKASHI Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Search for other papers by AKIKO AKASHI in
Current site
Google Scholar
PubMed
Close
, and
YUICHI HAMABE Department of Infectious Diseases and Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan

Search for other papers by YUICHI HAMABE in
Current site
Google Scholar
PubMed
Close
Restricted access

A 30-year-old Japanese woman with falciparum malaria was hospitalized because of fever and renal failure, and prolonged anemia was identified despite the eradication of malaria parasites through anti-malaria therapy. Bone marrow aspiration revealed the presence of macrophages with hemophagocytosis, and serum interleukin (IL)-18 and tumor necrosis factor (TNF)-α levels were high in the anemic phase. Hemophagocytosis was confirmed for at least 3 weeks, and prolonged hemophagocytic syndrome is thought to be one of the causes of prolonged anemia in patients with falciparum malaria.

Author Notes

  • 1

    Hamada A, Watanabe N, Tanaka H, Kobayashi A, 1989. Falci-parum malaria with bone marrow abnormalities resembling malignant histiocytosis. Trans R Soc Trop Med Hyg 83 :331.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2

    Anwar M, Salcem M, Malik A, 1995. Severe hemohagocytic syndrome in falciparum malaria. J Pak Med Assoc 45 :302–303.

  • 3

    Ohno T, Shirasaka A, Sugiyamma T, Furukawa H, 1996. Hemophagocytic syndrome induced by Plasmodium falciparum malaria infection. Int J Hemeatol 64 :263–266.

  • 4

    Retormaz F, Seux V, Arnoulet C, Durand JM, Sainty D, Soubeyrand J, 2000. Plasmodium falciparum malaria infection complicated by haemophagocytic syndrome in an old man. Acta Haematol 103 :224–225.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5

    Saribeyoglu ET, Anak S, Agaoglu L, Boral O, Unuvar A, Devecioglu O, 2004. Secondary hemophagocytic lymphohistiocytosis induced by malaria infection in a child with langerhans cell histiocytosis. Pediatr Hematol Oncol 21 :267–272.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6

    Sermet-Gaudelus I, Abadie V, Stambouli F, Hennequin C, Lenoir G, Gendrel D, 2000. Haemophagocytic syndrome in Plasmodium falciparum malaria. Acta Pediatr 89 :368–369.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 7

    Aouba A, Noguera ME, Clauvel JP, Quint L, 2000. Hemophagocytic syndrome associated with Plasmodium vivax infection. Br J Haematol 103 :832–833.

  • 8

    Zvulunov A, Tamary H, Gal N, 2002. Pancytopenia resulting from hemophagocytosis in malaria. Pediatr Infect Dis J 21 :1086–1088.

  • 9

    Park TS, Oh SH, Choi JC, Kim HH, Chang CL, Son HC, Lee EY, 2003. Plasmodium vivax malaria complicated by hemophagocytic syndrome in an immunocompetent serviceman. Am J Hemotol. 74 :127–130.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10

    Abdelkefi A, Othman TB, Torjan L, Ladeb S, Lakhal A, Belhadj S, Ayari S, Cherif N, Achour OB, Chaker E, Abdeladhim AB, 2004. Plasmodium falciparum causing hemophagocytic syndrome after allogeneic blood stem cell transplantation. Hematol J 5 :449–450.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 11

    Lay JD, Tsao CJ, Chen JY, Kadin ME, Su IJ, 1997. Upregulation of tumor necrosis factor-α gene by Epstein-Barr virus and activation of macrophages in Epstein-Barr virus-induuced T cells in the pathogenesis of hemophagocytic syndrome. J Clin Invest 52 :1969–1979.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 12

    Clark LA, Chaudhri G, 1988. Tumor necrosis factor may contribute to the anemia of malaria by causing dyserythropoiesis and erythrophagocytosis. Br J Haematol 70 :99–103.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13

    Takada H, Ohga S, Mizuno Y, Suminoe A, Matsuzaki A, Ihara K, Kinukawa N, Ohshima K, Kohno K, Kurimoto M, Hara T, 1999. Oversecretion of IL-18 in haemophagocytic lymphohistiocytosis: A novel marker of disease activity. Br J Haematol 106 :182–189.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 14

    Koizumi K, Yokoyama K, Nishio M, Shibata S, Ozutumi K, Yamaguchi M, Sato N, Yasukouchi T, Sawada K, Koike T, 1996. A case with virus-associated hemophagocytic syndrome (VAHS) complicated by rhabdomyolysis which were associated with herpes-simplex virus infection. Jpn J Clin Hematol 37 :40–45.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15

    Fujiki R, Shiraishi K, Noda K, Ohshita Y, Fukahori S, Johjima H, Tanaka K, Rikimaru T, Aizawa H, 2003. A case of hemophagocytic syndrome associated with military tuberculosis. Kekkaku 78 :443–448.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 16

    Goto S, Aoike I, Shibasaki Y, Morita T, Miyazaki S, Shimizu T, Suzuki M, 2001. A successfully treated case of disseminated tuberculosis-associated hemophagocytic syndrome and multiple organ dysfunction syndrome. Am J Kid Dis 38 :E19.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 17

    Sanada S, Ookawara S, Shindo T, Morino K, Ishikawa H, Suzuki M, 2004. A case report of the effect of plasma exchange on reactive hemophagocytic syndrome associated with Toxic shock syndrome. Therap Aphre Dialy 8 :503–506.

    • PubMed
    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 258 210 15
Full Text Views 219 7 4
PDF Downloads 55 7 4
 

 

 

 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save