• 1

    Jeronimo SM, de Queiroz Sousa A, Pearson RD, 2006. Leishmaniasis. Guerrant RL, Walker DH, Weller PF, eds. Tropical Infectious Diseases: Principles, Pathogens and Practice. Edinburgh, Scotland: Churchill Livingstone Elsevier, 1095–1113.

  • 2

    Sengupta PC, 1947. History of kala-azar in India. Ind Med Gaz 82 :281–286.

  • 3

    Nandy A, Neogy AB, Chowdhury AB, 1987. Leishmanin test survey in an endemic village of Indian kala-azar near Calcutta. Ann Trop Med Parasitol 81 :693–699.

    • Search Google Scholar
    • Export Citation
  • 4

    Jeronimo SM, Teixeira MJ, Sousa A, Thielking P, Pearson RD, Evans TG, 2000. Natural history of Leishmania (Leishmania) chagasi infection in northeastern Brazil: long-term follow-up. Clin Infect Dis 30 :608–609.

    • Search Google Scholar
    • Export Citation
  • 5

    Badaro R, Jones TC, Lorenco R, Cerf BJ, Sampaio D, Carvalho EM, Rocha H, Teixeira R, Johnson WD Jr, 1986. A prospective study of visceral leishmaniasis in an endemic area of Brazil. J Infect Dis 154 :639–649.

    • Search Google Scholar
    • Export Citation
  • 6

    Houghton RL, Petrescu M, Benson DR, Skeiky YA, Scalone A, Badaro R, Reed SG, Gradoni L, 1998. A cloned antigen (recombinant K39) of Leishmania chagasi diagnostic for visceral leishmaniasis in human immunodeficiency virus type 1 patients and a prognostic indicator for monitoring patients undergoing drug therapy. J Infect Dis 177 :1339–1344.

    • Search Google Scholar
    • Export Citation
  • 7

    Bern C, Amann J, Haque R, Chowdhury R, Ali M, Kurkjian KM, Vaz L, Wagatsuma Y, Breiman RF, Secor WE, Maguire JH, 2006. Loss of leishmanin skin test antigen sensitivity and potency in a longitudinal study of visceral leishmaniasis in Bangladesh. Am J Trop Med Hyg 75 :744–748.

    • Search Google Scholar
    • Export Citation
  • 8

    Moral L, Rubio EM, Moya M, 2002. A leishmanin skin test survey in the human population of l’Alacanti region (Spain): implications for the epidemiology of Leishmania infantum infection in southern Europe. Trans R Soc Trop Med Hyg 96 :129–132.

    • Search Google Scholar
    • Export Citation
  • 9

    Cerf BJ, Jones TC, Badaro R, Sampaio D, Teixeira R, Johnson WD Jr, 1987. Malnutrition as a risk factor for severe visceral leishmaniasis. J Infect Dis 156 :1030–1033.

    • Search Google Scholar
    • Export Citation
  • 10

    Karplus TM, Jeronimo SM, Chang H, Helms BK, Burns TL, Murray JC, Mitchell AA, Pugh EW, Braz RF, Bezerra FL, Wilson ME, 2002. Association between the tumor necrosis factor locus and the clinical outcome of Leishmania chagasi infection. Infect Immun 70 :6919–6925.

    • Search Google Scholar
    • Export Citation
  • 11

    Bucheton B, El-Safi SH, Hammad A, Kheir MM, Eudes N, Mirgani A, Dessein AJ, Mary C, 2003. Antileishmanial antibodies in an outbreak of visceral leishmaniasis in eastern Sudan: high antibody responses occur in resistant subjects and are not predictive of disease. Trans R Soc Trop Med Hyg 97 :463–468.

    • Search Google Scholar
    • Export Citation
  • 12

    World Health Organization Southeast Asia Regional Office, 2005. Press Release: Elimination of Kala-Azar from Endemic Countries in the South-East Asia Region: Health Ministers Sign Memorandum of Understanding.

  • 13

    Kubar J, Marty P, Lelievre A, Quaranta JF, Staccini P, Caroli-Bosc C, Le Fichoux Y, 1998. Visceral leishmaniosis in HIV-positive patients: primary infection, reactivation and latent infection. Impact of the CD4+ T-lymphocyte counts. AIDS 12 :2147–2153.

    • Search Google Scholar
    • Export Citation
  • 14

    de Rossell RA, de Duran RJ, Rossell O, Rodriguez AM, 1992. Is leishmaniasis ever cured? Trans R Soc Trop Med Hyg 86 :251–253.

  • 15

    Sharma MC, Gupta AK, Das VN, Verma N, Kumar N, Saran R, Kar SK, 2000. Leishmania donovani in blood smears of asymptomatic persons. Acta Trop 76 :195–196.

    • Search Google Scholar
    • Export Citation
  • 16

    Costa CH, Gomes RB, Silva MR, Garcez LM, Ramos PK, Santos RS, Shaw JJ, David JR, Maguire JH, 2000. Competence of the human host as a reservoir for Leishmania chagasi.J Infect Dis 182 :997–1000.

    • Search Google Scholar
    • Export Citation
  • 17

    Guarga JL, Lucientes J, Peribanez MA, Molina R, Gracia MJ, Castillo JA, 2000. Experimental infection of Phlebotomus perniciosus and determination of the natural infection rates of Leishmania infantum in dogs. Acta Trop 77 :203–207.

    • Search Google Scholar
    • Export Citation
  • 18

    Guarga JL, Moreno J, Lucientes J, Gracia MJ, Peribanez MA, Alvar J, Castillo JA, 2000. Canine leishmaniasis transmission: higher infectivity amongst naturally infected dogs to sand flies is associated with lower proportions of T helper cells. Res Vet Sci 69 :249–253.

    • Search Google Scholar
    • Export Citation
  • 19

    Courtenay O, Quinnell RJ, Garcez LM, Shaw JJ, Dye C, 2002. Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. J Infect Dis 186 :1314–1320.

    • Search Google Scholar
    • Export Citation
  • 20

    Travi BL, Tabares CJ, Cadena H, Ferro C, Osorio Y, 2001. Canine visceral leishmaniasis in Colombia: relationship between clinical and parasitologic status and infectivity for sand flies. Am J Trop Med Hyg 64 :119–124.

    • Search Google Scholar
    • Export Citation
  • 21

    Schaefer KU, Kurtzhals JA, Kager PA, Gachihi GS, Gramiccia M, Kagai JM, Sherwood JA, Muller AS, 1994. Studies on the prevalence of leishmanin skin test positivity in the Baringo District, Rift Valley, Kenya. Am J Trop Med Hyg 50 :78–84.

    • Search Google Scholar
    • Export Citation
  • 22

    Zijlstra EE, el-Hassan AM, Ismael A, Ghalib HW, 1994. Endemic kala-azar in eastern Sudan: a longitudinal study on the incidence of clinical and subclinical infection and post-kala-azar dermal leishmaniasis. Am J Trop Med Hyg 51 :826–836.

    • Search Google Scholar
    • Export Citation
  • 23

    Zijlstra EE, el-Hassan AM, 1993. Leishmanin and tuberculin sensitivity in leishmaniasis in the Sudan, with special reference to kala-azar. Trans R Soc Trop Med Hyg 87 :425–427.

    • Search Google Scholar
    • Export Citation
  • 24

    Bern C, Hightower AW, Chowdhury R, Ali M, Amann J, Wagatsuma Y, Haque R, Kurkjian K, Vaz LE, Begum M, Akter T, Cetre-Sossah CB, B.Ahluwalia I, Dotson E, Secor WE, Breiman RF, Maguire JH, 2005. Risk factors for kala-azar in Bangladesh. Emerg Infect Dis 11 :655–662.

    • Search Google Scholar
    • Export Citation
  • 25

    Ahluwalia IB, Bern C, Costa C, Akter T, Chowdhury R, Ali M, Alam D, Kenah E, Amann J, Islam M, Wagatsuma Y, Haque R, Breiman RF, Maguire JH, 2003. Visceral leishmaniasis: consequences of a neglected disease in a Bangladeshi community. Am J Trop Med Hyg 69 :624–628.

    • Search Google Scholar
    • Export Citation
  • 26

    Sokal JE, 1975. Editorial: measurement of delayed skin-test responses. N Engl J Med 293 :501–502.

  • 27

    Kurkjian KM, Vaz LE, Haque R, Cetre-Sossah C, Akhter S, Roy S, Steurer F, Amann J, Ali M, Chowdhury R, Wagatsuma Y, Williamson J, Crawford S, Breiman RF, Maguire JH, Bern C, Secor WE, 2005. Application of an improved method for the recombinant K39 enzyme-linked immunosorbent assay to detect visceral leishmaniasis disease and infection in Bangladesh. Clin Diagn Lab Immunol 12 :1410–1415.

    • Search Google Scholar
    • Export Citation
  • 28

    Driskell WJ, Neese JW, Bryant CC, Bashor MM, 1982. Measurement of vitamin A and vitamin E in human serum by high-performance liquid chromatography. J Chromatogr 231 :439–444.

    • Search Google Scholar
    • Export Citation
  • 29

    Lizana J, Hellsing K, 1974. Manual immunoephelometric assay of proteins, with use of polymer enhancement. Clin Chem 20 :1181–1186.

  • 30

    Smith JC Jr, Butrimovitz GP, Purdy WC, 1979. Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 25 :1487–1491.

    • Search Google Scholar
    • Export Citation
  • 31

    Brown KH, Lanata CF, Yuen ML, Peerson JM, Butron B, Lonnerdal B, 1993. Potential magnitude of the misclassification of a population’s trace element status due to infection: example from a survey of young Peruvian children. Am J Clin Nutr 58 :549–554.

    • Search Google Scholar
    • Export Citation
  • 32

    Ballew C, Bowman BA, Sowell AL, Gillespie C, 2001. Serum retinol distributions in residents of the United States: third National Health and Nutrition Examination Survey, 1988–1994. Am J Clin Nutr 73 :586–593.

    • Search Google Scholar
    • Export Citation
  • 33

    Badaro R, Jones TC, Carvalho EM, Sampaio D, Reed SG, Barral A, Teixeira R, Johnson WD Jr, 1986. New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 154 :1003–1011.

    • Search Google Scholar
    • Export Citation
  • 34

    Costa CH, Stewart JM, Gomes RB, Garcez LM, Ramos PK, Bozza M, Satoskar A, Dissanayake S, Santos RS, Silva MR, Shaw JJ, David JR, Maguire JH, 2002. Asymptomatic human carriers of Leishmania chagasi.Am J Trop Med Hyg 66 :334– 337.

    • Search Google Scholar
    • Export Citation
  • 35

    Ho M, Siongok TK, Lyerly WH, Smith DH, 1982. Prevalence and disease spectrum in a new focus of visceral leishmaniasis in Kenya. Trans R Soc Trop Med Hyg 76 :741–746.

    • Search Google Scholar
    • Export Citation
  • 36

    Caldas AJ, Costa JM, Silva AA, Vinhas V, Barral A, 2002. Risk factors associated with asymptomatic infection by Leishmania chagasi in north-east Brazil. Trans R Soc Trop Med Hyg 96 :21–28.

    • Search Google Scholar
    • Export Citation
  • 37

    Anstead GM, Chandrasekar B, Zhao W, Yang J, Perez LE, Melby PC, 2001. Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect Immun 69 :4709–4718.

    • Search Google Scholar
    • Export Citation
  • 38

    Van Weyenbergh J, Santana G, d’Oliveira A Jr, Santos AF Jr, Costa CH, Carvalho EM, Barral A, Barral-Netto M, 2004. Zinc/copper imbalance reflects immune dysfunction in human leishmaniasis: an ex vivo and in vitro study. BMC Infect Dis 4 :50.

    • Search Google Scholar
    • Export Citation
  • 39

    Dye C, Williams BG, 1993. Malnutrition, age and the risk of parasitic disease: visceral leishmaniasis revisited. Proc R Soc Lond B Biol Sci 254 :33–39.

    • Search Google Scholar
    • Export Citation
  • 40

    Harrison LH, Naidu TG, Drew JS, de Alencar JE, Pearson RD, 1986. Reciprocal relationships between undernutrition and the parasitic disease visceral leishmaniasis. Rev Infect Dis 8 :447–453.

    • Search Google Scholar
    • Export Citation
  • 41

    Reddy V, Bhaskaram P, Raghuramulu N, Milton RC, Rao V, Madhusudan J, Krishna KV, 1986. Relationship between measles, malnutrition, and blindness: a prospective study in Indian children. Am J Clin Nutr 44 :924–930.

    • Search Google Scholar
    • Export Citation
  • 42

    Mitra AK, Alvarez JO, Wahed MA, Fuchs GJ, Stephensen CB, 1998. Predictors of serum retinol in children with shigellosis. Am J Clin Nutr 68 :1088–1094.

    • Search Google Scholar
    • Export Citation
  • 43

    Mittal V, Bhatia R, Sehgal S, 1991. Serodiagnosis of Indian kala-azar: evaluation of IFA, ELISA and CIEP tests. J Commun Dis 23 :131–134.

    • Search Google Scholar
    • Export Citation
  • 44

    Rose G, 1985. Sick individuals and sick populations. Int J Epidemiol 14 :32–38.

  • 45

    Bowman BA, Bern C, Philen RM, 1996. Nothing’s simple about malnutrition: complexities raised by epidemic neuropathy in Cuba. Am J Clin Nutr 64 :383–384.

    • Search Google Scholar
    • Export Citation
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THE EPIDEMIOLOGY OF VISCERAL LEISHMANIASIS AND ASYMPTOMATIC LEISHMANIAL INFECTION IN A HIGHLY ENDEMIC BANGLADESHI VILLAGE

CARYN BERNCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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RASHIDUL HAQUECenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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RAJIB CHOWDHURYCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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MUSTAKIM ALICenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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KATIE M. KURKJIANCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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LOUISE VAZCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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JOSEF AMANNCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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M. A. WAHEDCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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YUKIKO WAGATSUMACenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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ROBERT F. BREIMANCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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JOHN WILLIAMSONCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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W. EVAN SECORCenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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JAMES H. MAGUIRECenters for Disease Control and Prevention, Atlanta, Georgia; International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

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We examined the epidemiology of kala-azar and asymptomatic leishmanial infection measured by serologic and leishmanin skin test results in a Bangladeshi community. In a subset, we measured serum retinol, zinc and C-reactive protein (CRP). Kala-azar and seroconversion incidence were 15.6 and 63.1 per 1,000 person-years, respectively. Proximity to a previous kala-azar case increased the likelihood of both kala-azar and asymptomatic infection. Bed net use protected against kala-azar (rate ratio = 0.35, P < 0.01), but not subclinical infection (rate ratio = 1.1, P = 0.82). Kala-azar patients were younger (P < 0.001) and reported lower red meat consumption (P < 0.01) than asymptomatic seropositive individuals. Retinol and zinc levels were lower in current kala-azar patients and those who later developed kala-azar compared with uninfected and asymptomatically infected subjects. The CRP levels were higher in kala-azar patients compared with the other two groups. Low red meat intake and poor zinc and retinol status may characterize a group at higher risk of symptomatic disease.

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