Grimaldi G Jr, Tesh RB, McMahon-Pratt D, 1989. A review of the geographic distribution and epidemiology of leishmaniasis in the new world. Am J Trop Med Hyg 41 :687–725.
Handman E, 2001. Leishmaniasis: Current status of vaccine development. Clin Microbiol Rev 14 :229–243.
Costa JML, Saldanha ACR, Melo e Silva AC, Neto AS, Galvao CES, Pedroso e Silva CMO, Silva AR, 1992. Estado actual da leishmaniose cutánea difusa (LCD) no Estado do Maranhao. II. Aspedctos epidemiológicos, clinicoevolutivos. Rev Soc Bras Med Trop 25 :115–123.
Bomfim G, Nascimento C, Costa J, Carvalho EM, Barral-Netto M, Barral A, 1996. Variation of cytokine patterns related to therapeutic response in diffuse cutaneous leishmaniasis. Exp Parasitol 84 :188–194.
Boom WH, Liebster L, Abbas AK, Titus RG, 1990. Patterns of cytokine secretion in murine leishmaniasis: Correlation with disease progression or resolution. Infect Immun 58 :3863–3870.
Cuttolo M, 1997. Do sex hormones modulate the synovial macrophages in rheumatoid arthritis? Ann Rheum Dis 56 :281–283.
Giltay EJ, Fonk JCM, von Blomberg BME, Drexhage HA, Schalkwijk C, Gooren LJG, 2000. In vivo effects of sex steroids on Lymphocyte responsiveness and Immunoglobulin levels in humans. J Clin Endocrin Metabol 85 :1648–1657.
Clerici M, Galli M, Bosis S, Gervasoni C, Moroni M, Norbiato G, 2000. Immunoendocrinologic abnormalities in human immunodeficiency virus infection. Ann N Y Acad Sci 917 :956–961.
Hernandez-Pando R, Streber ML, Orozco H, Arriaga K, Pavon L, Marti O, Lightman SL, Rook GAW, 1998. Emergent immunoregulatory properties of combined glucocorticoid and anti-glucocorticoid steroids in a model of tuberculosis. Q J Med 91 :755–766.
Imrich R, 2002. The role of neuroendocrine system in the pathogenesis of rheumatic diseases (minireview). Endocr Regul 36 :95–106.
Young DG, Skibinski G, Mason JI, James K, 1999. The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors. Clin Exp Immunol 117 :476–481.
Straub RH, Konecna L, Hrach S, Rothe G, Kreutz M, Schölmerich J, Falk W, Lang B, 1998. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum inteleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: Possible link between endocrinosenescence and immunosenescence. J Clin Endocrin Metabol 83 :2012–2017.
Morley JE, Kaiser F, Raum WJ, Perry HM III, Flood JF, Jensen J, Silver AJ, Roberts E, 1997. Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. Proc Natl Acad Sci USA 94 :7537–7542.
Keller ET, Chang C, Ershler WB, 1996. Inhibition of NF kappa B activity through maintenance of IkappaB alpha levels contributes to dihydrotestosterone-mediated repressin of the interleu-kin-6 promoter. J Biol Chem 271 :26267–26275.
McLachlan JA, Serkin CD, Bakouche O, 1996. Dehydroepiandrosterone modulation of lipopolysaccharide-stimulated monocyte cytotoxicity. J Immunol 156 :328–335.
Daynes RA, Araneo BA, Dowell TA, Huang K, Dudley D, 1990. Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function. J Exp Med 171 :979–996.
Chang DM, Lan JL, Lin H, Luo SF, 2002. Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: A multicenter randomized, double-blind, placebo-controlled trial. Arthritis Rheum 46 :2924–2927.
Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M, 1995. Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science 270 :286–290.
Scheinman RI, Cogswell PC, Lofquist AL, Baldwin AS Jr, 1995. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 270 :283–286.
Hu X, Li WP, Meng C, Ivashkiv LB, 2003. Inhibition of IFN-γ signaling by glucocorticoids. J Immunol 170 :4833–4839.
Zhang Z, Jones S, Hagood JS, Fuentes NL, Fuller GM, 1997. STAT3 acts as a co-activator of glucocorticoid receptor signaling. J Biol Chem 272 :30607–30610.
Jaffe CL, McMahon-Pratt D, 1983. Monoclonal antibodies specific for Leishmania tropica. I. Characterization of antigens associated with stage- and species-specific determinants. J Immunol 131 :1987–1993.
McMahon-Pratt D, Bennett E, Grimaldi G, Jaffe CL, 1985. Subspecies- and species-specific antigens of Leishmania mexicana characterized by monoclonal antibodies. J Immunol 134 :1935–1940.
McMahon-Pratt D, Bennett E, David JR, 1982. Monoclonal antibodies that distinguish subspecies of Leishmania braziliensis. J Immunol 129 :926–927.
McMahon-Pratt D, David JR, 1981. Monoclonal antibodies that distinguish between New World species of Leishmania. Nature 291 :581–583.
Skeiky YAW, Benson DR, Jackson LM, Costa JLM, Badaro R, Reed SG, 1997. Association of Leishmania heat shock protein 83 antigen and immunoglobulin G4 antibody titers in Brazilian patients with diffuse cutaneous leishmaniasis. Infect Immun 65 :5368–5370.
Robinzon B, Cutolo M, 1999. Should dehydroepiandrosterone replacement therapy be provided with glucocorticoids? Rheumatol 38 :488–495.
Turetz ML, Machado PR, Ko AI, Alves F, Bittencourt A, Almeida RP, Mobashery N, Johnson WD Jr, Carvalho EM, 2002. Disseminated Leishmaniasis: A new and emerging form of leishmaniasis observed in Northeastern Brazil. J Infect Dis 186 :1829–1834.
Ajdary S, Alimohammadian MH, Eslami MB, Kemp K, Kharazmi A, 2000. Comparison of the immune profile of non-healing cutaneous leishmaniasis patients with those with active lesions and those who have recovered from infection. Infect Immun 68 :1760–1764.
Straub RH, Lehle K, Herfarth H, Weber M, Falk W, Preuner J, Schölmerich J, 2002. Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: Role of interleukin-6 and tumor necrosis factor. Eur J Endocrinol 146 :365–374.
Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, Pollmächer T, 2000. Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers. J Clin Endocrin Metabol 85 :4624–4629.
Straub RH, Vogl D, Gross V, Lang B, Schölmerich J, Andus T, 1998. Association of humoral markers of inflammation and dehydroepiandrostorone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease. Am J Gastroenterol 93 :2197–2202.
Sambrook PN, Eisman JA, Champion GD, Pocock NA, 1988. Sex hormone status and osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis Rheum 31 :937–978.
Deighton CM, Watson MJ, Walker DJ, 1992. Sex hormones in postmenopausal HLA-identical rheumatoid arthritis discordant sibling pairs. J Rheumatol 19 :1663–1667.
Lahita RG, Bradlolw HL, Ginzler E, Pang S, New M, 1987. Low plasma androgens in women with systemic lupus erythematosus. Arthritis Rheum 30 :241–248.
De la Torre B, Fransson J, Scheynius A, 1995. Blood dehydroepiandrosterone susphate (DHEA) levels in pemphigoid/Pemphigous and psoriasis. Clin Exp Rheumatol 13 :345–348.
Velasco-Castrejon O, Walton BC, Rivas-Sánchez B, Garcia ME, Lazaro GJ, Hobart O, Roldan S, Floriani-Verdugo J, Munguia-Saldana A, Berzaluce R, 1997. Treatment of cutaneous Leishmaniasis with localized current field (radio frequency) in Tabasco, México. Am J Trop Med Hyg 57 :309–312.
Velasco O, Savarino SJ, Walton BC, Gam AA, Neva FA, 1989. Diffuse cutaneous leishmaniasis in Mexico. Am J Trop Med Hyg 41 :280–288.
Mandujano-Vera G, 1988. Leishmaniasis en Tabasco, México. Informe de 92 casos, uno de espundia. Patología (México) 26 :87–92.
Kurtis JD, Mtalib R, Onyango FK, Duffy PE, 2001. Human resistance to Plasmodium falciparum increases during puberty and is predicted by dehydroepiandrosterone sulfate levels. Infect Immun 69 :123–128.
Danenberg HD, Alpert G, Lustig S, Ben-Nathan D, 1992. Dehydroepiandrosterone protects mice from endotoxin toxicity and reduces tumor necrosis factor production. Antimicrob Agents Chemother 36 :2275–2279.
Di Santo E, Foddi MC, Ricciardi-Castagnoli P, Mennini T, Ghezzi P, 1996. DHEA inhibits TNF production in monocytes, astrocytes and microglial cells. Neuroimmunomodulation 3 :285–288.
Kimura M, Tanaka S, Yamada Y, Kiuchi Y, Yamakawa R, Sekihara H, 1998. Dehydroepiandrosterone decreases serum tumor necrosis factor-alpha and restores insulin sensitivity-independent effect from secondary weight reduction in genetically obese Zucker fatty rats. Endocrinology 139 :3249–3253.
Padgett DA, Loria M, 1998. Endocrine regulation of murine macrophage function: effects of dehydroepiandrosterone, androstenediol, and androstenetriol. J Neuroimmunol 84 :61–68.
Daynes RA, Araneo BA, Ershler WB, Maloney C, Li G, Ryu S, 1993. Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfate derivative. J Immunol 150 :5219–5230.
Gu S, Ripp SL, Prough RA, Geoghegan TE, 2003. Dehydroepiandrosterone affects the expression of multiple genes in rat liver including 11b-hydroxysteroid dehydrogenase type 1: A cDNA Array analysis. Mol Pharmacol 63 :722–731.
Williams MRI, Dawood T, Ling S, Dai A, Lew R, Myles K, Funder JW, Sudhir K, Komesaroff PA, 2004. Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 89 :4708–4715.
Simoncini T, Mannella P, Fornari L, Gaetano V, Caruso A, Genazzani AR, 2003. Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 144 :3449–3455.
Liu D, Dillon JS, 2002. Dehydroepiandrosterone activates endothelial cell nitricoxide synthase by a specific plasma membrane receptor coupled to Gα (i2,3). J Biol Chem 277 :21379–21388.
Beck SG, Handa RJ, 2004. Dehydroepiandrosterone (DHEA): A misunderstood adrenal hormone and spine-tingling neurosteroid? Endocrinology 145 :1039–1041.
Deshpande R, Khalili H, Pergolizzi RG, Michael SD, Chang MD, 1997. Estradiol down-regulates LPS-induced cytokine production and NFkB activation in murine macrophages. Am J Reprod Immunol 38 :46–54.
Ralston SH, Russell RG, Gowen M, 1990. Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women. J Bone Miner Res 5 :983–988.
Shanker G, Sorci-Thomas M, Adams MR, 1994. Estrogens modulates the expression of tumor necrosis factor alpha mRNA in phorbol ester-stimulated human monocytic THP-1 cells. Lymphokine Cytokine Res 13 :377–382.
Pottratz ST, Bellido T, Mocharla H, Crabb D, Manolagas SC, 1994. 17 Beta-estradiol inhibitis expression of human interleu-kin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest 93 :944–950.
Ray A, Prefontaine KE, Ray P, 1994. Down-modulation of in-teleuki-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J Biol Chem 269 :12940–12946.
Kassem M, Harris SA, Spelsberg TC, Riggs BL, 1996. Estrogen inhibits interleukin-6 production and gene expression in a human osteoblastic cell line with high levels of estrogens receptors. J Bone Miner Res 11 :193–199.
Sukovich DA, Kauser K, Shirley FD, DelVecchio V, Halks-Miller M, Rubanyi GM, 1998. Expression of interleukin-6 in atherosclerotic lesion of male ApoE-knockout mice: Inhibition by 17beta-estradiol. Arterio Thromb Vasc Biol 18 :1498–1505.
Freilich D, Ferris S, Wallace M, Leach L, Kallen A, Frincke J, Ahlem C, Hacker M, Nelson D, Hebert J, 2000. 16α-Bromoepiandrosterone, a dehydroepiandrosterone (DHEA) analogue, inhibits Plasmodium falciparum and Plasmodium berghei growth. Am J Trop Med Hyg 63 :280–283.
Cooper MS, Stewart PM, 2003. Current concepts: Corticosteroid insufficiency in acutely ill patients. N Engl J Med 348 :727–734.
Hamrahian AH, Osen TS, Arafah BA, 2004. Measurements of serum free cortisol in critically ill patients. N Engl J Med 350 :1629–1638.
Diaz NL, Zerpa O, Ponce LV, Convit J, Rondon AJ, Tapia FJ, 2002. Intermediate or chronic cutaneous leishmaniasis: Leukocyte immunophenotypes and cytokine characterisation of the lesion. Exp Dermatol 11 :34–41.
Rogers KA, Titus RG, 2004. Characterization of the early cellular immune response to Leishmania major using peripheral blood mononuclear cells from Leishmania-naive humans. Am J Trop Med Hyg 71 :568–576.
Colmenares M, Sujata K, Goldsmith-Pestana K, McMahon-Pratt D, 2002. Mechanisms of pathogenesis: Differences amongst Leishmania species. Trans R Soc Trop Med Hyg 96 :S3–S17.
Sacks D, Noben-Trauth N, 2002. The immunology of susceptibility and resistance to Leishmania major in mice. Nat Rev Immunol 2 :845–858.
Lang T, Courret N, Colle J, Milon G, Antoine J, 2003. The levels and patterns of cytokines produced by CD4 T lymphocytes of BALB/c mice infected with Leishmania major by inoculation into the ear dermis depend on the infectiousness and size of the inoculum. Infect Immun 71 :2674–2683.
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Low levels of dehydroepiandrosterone (DHEA) and cortisol hormones produced by the suprarenal cortex have been associated with diseases involving chronic inflammation, low interferon (IFN)-γ, and high interleukin (IL)-6. Diffuse cutaneous leishmaniasis (DL), a long-lasting intracellular parasitic infectious disease, can spread unknown levels of DHEA and cortisol. Serum concentrations of both were measured in 5 patients with DL, in 15 patients with localized lesions produced by Leishmania (LL), and in 20 healthy volunteers. Leishmania mexicana mexicana was identified as the causal agent in patients with DL and LL. Hormone levels were lower in DL compared with controls and LL. Furthermore, we detected a lower percentage of IFN-γ–positive cells with higher levels of IL-6 and higher titers of anti-Leishmania antibodies in patients with DL, whereas patients with LL were similar to controls. These data suggest that patients with DL may be good candidates for DHEA and cortisol supplementation.