LEPTOSPIROSIS IN KAMPHAENG PHET, THAILAND

KHIN S. A. MYINT Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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ROBERT V. GIBBONS Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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CLINTON K. MURRAY Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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KAMCHAI RUNGSIMANPHAIBOON Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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WITAYA SUPORNPUN Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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RATANA SITHIPRASASNA Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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MICHAEL R. GRAY Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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CHUSAK PIMGATE Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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MAMMEN P. MAMMEN JR Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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DUANE R. HOSPENTHAL Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand; Brooke Army Medical Center and Veterinary Command, Fort Sam Houston, Texas; Kamphaeng Phet Provincial Hospital, Thailand; Kamphaeng Phet Provincial Health Office, Thailand

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Leptospirosis, which is caused by pathogenic spirochetes of the genus Leptospira, is a zoonotic disease of global importance and an emerging health problem. We studied patients suspected of having leptospirosis in Kamphaeng Phet Province, Thailand. Of 106 patients with suspected leptospirosis evaluated at the provincial hospital, 69 (65%) were confirmed positive (titer ≥ 1:800 or ≥ 4-fold increase in titer) by microscopic agglutination testing. Seventy-seven percent (53) of the cases occurred during the rainy season (June through November). Sera reacted predominantly with Bratislava, Autumnalis, and Icterohaemorrhagiae serovars. The screening Leptospira Dip-S-Ticks test had poor sensitivity (32%) but a specificity of 100% compared with a Leptospira IgM enzyme-linked immunosorbent assay. Leptospirosis was found to be a frequently confirmed cause of morbidity in Kamphaeng Phet Province in those suspected of having the illness.

Author Notes

Reprint requests: Clinton K. Murray, Brooke Army Medical Center, 3851 Roger Brooke Drive, 7 East/MCHE-MDI, Fort Sam Houston, TX 78234, Telephone: 210-916-3847, Fax: 210-916-0388.
  • 1

    Levett PN, 2001. Leptospirosis. Clin Microbiol Rev 14 :296–326.

  • 2

    CDC Update: Leptospirosis and unexplained acute febrile illness among athletes participating in triathlons-Illinois and Wisconsin, 1998. MMWR Morb Mortal Wkly Rep 47 :673–676.

    • Search Google Scholar
    • Export Citation
  • 3

    Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM, 2003. Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 3 :757–771.

    • Search Google Scholar
    • Export Citation
  • 4

    Vinetz JM, 2001. Leptospirosis. Curr Opin Infect Dis 14 :527–538.

  • 5

    Levett PN, Morey RE, Galloway RL, Turner DE, Steigerwalt AG, Mayer LW, 2005. Detection of pathogenic leptospires by real-time quantitative PCR. J Med Microbiol 54 :45–49.

    • Search Google Scholar
    • Export Citation
  • 6

    Levett PN, 2003. Usefulness of serologic analysis as a predictor of the infecting serovar in patients with severe leptospirosis. Clin Infect Dis 36 :447–452.

    • Search Google Scholar
    • Export Citation
  • 7

    Phraisuwan P, Whitney EA, Tharmaphornpilas P, Guharat S, Thongkamsamut S, Aresagig S, Liangphongphanthu J, Junthima K, Sokampang A, Ashford DA, 2002. Leptospirosis: skin wounds and control strategies, Thailand, 1999. Emerg Infect Dis 8 :1455–1459.

    • Search Google Scholar
    • Export Citation
  • 8

    Tangkanakul W, Smits HL, Jatanasen S, Ashford DA, 2005. Leptospirosis: an emerging health problem in Thailand. Southeast Asian J Trop Med Public Health 36 :281–288.

    • Search Google Scholar
    • Export Citation
  • 9

    Tangkanakul W, Hinjoy S, Smithsuwan P, Phulsuksombati D, Choomkasien P, 2002. Leptospira serovar in humans and animals, Nakhon Ratchasima. Monthly Epidemiol Surveill Rep 33 :155–162.

    • Search Google Scholar
    • Export Citation
  • 10

    Heisey GB, Nimmanitya S, Karnchanachetanee C, Tingpalapong M, Samransamruajkit S, Hansukjariya P, Elwell MR, Ward GS, 1988. Epidemiology and characterization of leptospirosis at an urban and provincial site in Thailand. Southeast Asian J Trop Med Public Health 19 :317–322.

    • Search Google Scholar
    • Export Citation
  • 11

    Bunnag T, Potha U, Thirachandra S, Impand P, 1983. Leptospirosis in man and rodents in north and northeast Thailand. Southeast Asian J Trop Med Public Health 14 :481–487.

    • Search Google Scholar
    • Export Citation
  • 12

    Zaki S, Spiegel RA, 1998. Leptospirosis. Nelson AM, Horsburgh RC, eds. Pathology of Emerging Infections. Second edition. Washington, DC: American Society for Microbiology, 73–76.

  • 13

    Barcellos C, Lammerhirt CB, de Almeida MA, dos Santos E, 2003. Spatial distribution of leptospirosis in Rio Grande do Sul, Brazil: recovering the ecology of ecological studies. Cad Saude Publica 19 :1283–1292.

    • Search Google Scholar
    • Export Citation
  • 14

    Barcellos C, Sabroza PC, 2001. The place behind the case: leptospirosis risks and associated environmental conditions in a flood-related outbreak in Rio de Janeiro. Cad Saude Publica 17 (Suppl):59–67.

    • Search Google Scholar
    • Export Citation
  • 15

    Barcellos C, Sabroza PC, 2000. Socio-environmental determinants of the leptospirosis outbreak of 1996 in western Rio de Janeiro: a geographical approach. Int J Environ Health Res 10 :301–313.

    • Search Google Scholar
    • Export Citation
  • 16

    Public Health Statistics, 2001. Bangkok, Thailand: Ministry of Public Health, 189.

  • 17

    Statistical Reports of Changwat, 2002. Kamphaeng Phet, Thailand: National Statistical Office, Office of the Prime Minister. Table 1.1.

  • 18

    Winslow WE, Merry DJ, Pirc ML, Devine PL, 1997. Evaluation of a commercial enzyme-linked immunosorbent assay for detection of immunoglobulin M antibody in diagnosis of human leptospiral infection. J Clin Microbiol 35 :1938–1942.

    • Search Google Scholar
    • Export Citation
  • 19

    Faine S, 1988. Leptospirosis. Balows A, Hausler WJ, Ohashi M, Turano A, eds. Laboratory Diagnosis of Infectious Diseases: Principles and Practice. New York: Springer-Verlag, 344–352.

  • 20

    Wongsrichanalai C, Murray CK, Gray M, Miller RS, McDaniel P, Liao WJ, Pickard AL, Magill AJ, 2003. Co-infection with malaria and leptospirosis. Am J Trop Med Hyg 68 :583–585.

    • Search Google Scholar
    • Export Citation
  • 21

    Levett PN, Branch SL, Whittington CU, Edwards CN, Baxton H, 2001. Two methods for rapid serological diagnosis of acute leptospirosis. Clin Diagn Lab Immunol 8 :349–351.

    • Search Google Scholar
    • Export Citation
  • 22

    Bajani MD, Ashford DA, Bragg SL, Woods CW, Aye T, Spiegel RA, Plikaytis BD, Perkins BA, Phelan M, Levett PN, Weyant RS, 2003. Evaluation of four commercially available rapid serologic tests for diagnosis of leptospirosis. J Clin Microbiol 41 :803–809.

    • Search Google Scholar
    • Export Citation
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