SUCCESSFUL TREATMENT OF BLACK-GRAIN MYCETOMA WITH VORICONAZOLE

PIERRE LOULERGUE Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by PIERRE LOULERGUE in
Current site
Google Scholar
PubMed
Close
,
ARNAUD HOT Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by ARNAUD HOT in
Current site
Google Scholar
PubMed
Close
,
ERIC DANNAOUI Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by ERIC DANNAOUI in
Current site
Google Scholar
PubMed
Close
,
ALEXIANE DALLOT Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by ALEXIANE DALLOT in
Current site
Google Scholar
PubMed
Close
,
SYLVAIN POIRÉE Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by SYLVAIN POIRÉE in
Current site
Google Scholar
PubMed
Close
,
BERTRAND DUPONT Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by BERTRAND DUPONT in
Current site
Google Scholar
PubMed
Close
, and
OLIVIER LORTHOLARY Centre d’Infectiologie Necker-Pasteur, et Service de Radiologie, Hôpital Necker-Enfants Malades, Université Paris V, Paris, France; Centre National de Référence Mycologie et Antifongiques, Centre National de la Recherche Scientifique FRE2849, Institut Pasteur, Paris, France; Laboratoire Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, Paris, France; Service de Dermatologie, Hôpital Robert Ballanger, Aulnay sous, Bois, France

Search for other papers by OLIVIER LORTHOLARY in
Current site
Google Scholar
PubMed
Close
Restricted access

Fungal mycetoma (or eumycetoma) are endemic diseases in tropical areas that have economic effects because of their chronic and disabling evolution. Classic treatments include surgery and antifungal drugs, but these have multiple side effects. We report a case of black-grain fungal mycetoma successfully treated with voriconazole without side effects. The duration of the treatment remains unclear, but must be prolonged because of the frequency of relapses.

  • 1

    Maiti PK, Ray A, Bandyopadhyay S, 2002. Epidemiological aspects of mycetoma from a retrospective study of 264 cases in West Bengal. Trop Med Int Health 7 :788–792.

    • Search Google Scholar
    • Export Citation
  • 2

    Hay RJ, 2002. Fungal infections. Cook G, Zumla AI, eds. Manson’s Tropical Diseases. 21st edition. Philadelphia: W. B. Saunders, 1180–182.

  • 3

    Ahmed AO, van Leeuwen W, Fahal A, van de Sande W, Verbrugh H, van Belkum A, 2004. Mycetoma caused by Madurella mycetomatis: a neglected infectious burden. Lancet Infect Dis 4 :566–574.

    • Search Google Scholar
    • Export Citation
  • 4

    Lacroix C, de Kerviler E, Morel P, Derouin F, Feuilhade de Chauvin M, 2005. Madurella mycetomatis mycetoma treated successfully with oral voriconazole. Br J Dermatol 152 :1067–1068.

    • Search Google Scholar
    • Export Citation
  • 5

    Schwarz P, Bretagne S, Gantier JC, Garcia-Hermoso D, Lortholary O, Dromer F, Dannaoui E, 2006. Molecular identification of zygomycetes from culture and experimentally infected tissues. J Clin Microbiol 44 :340–349.

    • Search Google Scholar
    • Export Citation
  • 6

    Mouas H, Lutsar I, Dupont B, Fain O, Herbrecht R, Lescure FX, Lortholary O, Voriconazole/Bone Invasive Aspergillosis Study Group, 2005. Voriconazole for invasive bone aspergillosis: a worldwide experience of 20 cases. Clin Infect Dis 40 :1141–1147.

    • Search Google Scholar
    • Export Citation
  • 7

    Ndiaye B, Dieng MT, Perez A, Stockmeyer M, Bakshi R, 2006. Clinical efficacy and safety of oral terbinafine in fungal mycetoma. Int J Dermatol 45 :154–157.

    • Search Google Scholar
    • Export Citation
  • 8

    Negroni R, Tobon A, Bustamante B, Shikanai-Yasuda MA, Patino H, Restrepo A, 2005. Posaconazole treatment of refractory eumycetoma and chromoblastomycosis. Rev Inst Med Trop Sao Paulo 47 :339–346.

    • Search Google Scholar
    • Export Citation
  • 9

    Chakraborty A, Workman MR, Bullock PR, 2005. Scedosporium apiospermum brain abscess treated with surgery and voriconazole. Case report. J Neurosurg 103 :83–87.

    • Search Google Scholar
    • Export Citation
  • 10

    Husain S, Munoz P, Forrest G, Alexander BD, Somani J, Brennan K, Wagener MM, Singh N, 2005. Infections due to Scedosporium apiospermum and Scedosporium prolificans in transplant recipients: clinical characteristics and impact of antifungal agent therapy on outcome. Clin Infect Dis 40 :89–99.

    • Search Google Scholar
    • Export Citation
  • 11

    Consigny S, Dhedin N, Datry A, Choquet S, Leblond V, Chosidow O, 2003. Successsful voriconazole treatment of disseminated Fusarium infection in an immunocompromised patient. Clin Infect Dis 37 :311–313.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 19 19 6
Full Text Views 530 251 1
PDF Downloads 134 35 0
 
Membership Banner
 
 
 
Affiliate Membership Banner
 
 
Research for Health Information Banner
 
 
CLOCKSS
 
 
 
Society Publishers Coalition Banner
Save