- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Profiles of S. japonicum infection and morbidity assessed by ultrasound.
- CD4+T cells, CD4+/CD8+ T-cell count ratios and antibody levels in fishermen compared with naïve controls.
- Implications of CD4+, CD4+/CD8+ T-cell ratios, and antibodies in infection and intensity of infection with S. japonicum.
- CD4+ T cells, CD4+/CD8 + T-cell ratios, and antibodies in liver parenchymal fibrosis subjects detected by ultrasound.
- DISCUSSION
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CD4+ T-CELL COUNTS, CD4+/CD8+ T-CELL COUNT RATIOS, AND ANTIBODY LEVELS IN MIGRANT FISHERMEN INFECTED WITH SCHISTOSOMA JAPONICUM IN THE DONGTING LAKE, CHINA
In this study, CD4+ and CD8+ T cells and antibody levels were measured in 94 migrant fishermen infected with Schistosoma japonicum from Dongting Lake, China. Prevalence among these fishermen was high (63.8%), with a mean infection intensity of 61.4 ± 3.8 epg, and included a high proportion of individuals (39.4%) with substantial parenchymal fibrosis (stages ≥ 2/3). The CD4+/CD8+ ratio in men (1.34 ± 0.11) was significantly lower than that of women (1.58 ± 0.15). CD4+ T cells and the ratio of CD4+/CD8+ were significantly decreased both in subjects infected with S. japonicum and those with parenchymal fibrosis. However, levels of total IgA, IgM, and anti-schistosome egg antigen IgG correlated positively with infection intensity and pathologic lesion number. These results suggest an imbalance between cell-mediated and humoral immunity in these fishermen, the precise cause of which remains undetermined.