Author:
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Profiles of S. japonicum infection and morbidity assessed by ultrasound.
- CD4+T cells, CD4+/CD8+ T-cell count ratios and antibody levels in fishermen compared with naïve controls.
- Implications of CD4+, CD4+/CD8+ T-cell ratios, and antibodies in infection and intensity of infection with S. japonicum.
- CD4+ T cells, CD4+/CD8 + T-cell ratios, and antibodies in liver parenchymal fibrosis subjects detected by ultrasound.
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Stavitsky AB, 2004. Regulation of granulomatous inflammation in experimental models of schistosomiasis. Infect Immun 72 :1–12.
-
2
Cottrell BJ, Humber D, Sturrock RF, 1980. An immunosupressive factor in the serum of patients with schistosomiasis. Trans R Soc Trop Med Hyg 74 :415–416.
-
3
Li HZ, Cai WM, 1991. Preliminary study on peripheral blood T cell subset and B lymphocyte from patients in advanced stage of schistosomiasis. Chinese J Schistosomiasis Control 3 :282–283.
-
4
Li ZJ, Yang Q, Yang XY, 1992. The relationship between IL-1 and changes of peripheral blood T cells sub-class from patients with schistosomiasis. Chinese J Parasit Dis Control 5 :202–203.
-
5
Lin RP, 1994. Clinical value of testing peripheral blood lymphocyte subjet of patients with chronic schistosomiasis. J Pract Parasitic Dis 2 :31–33.
-
6
Li YS, He YK, Zeng QR, McManus DP, 2003. Epidemiological and morbidity assessment of Schistosoma japonicum infection in a migrant fisherman community, the Dongting Lake region, China. Trans R Soc Trop Med Hyg 97 :177–181.
-
7
Katz N, Caves A, Pelegrina J, 1972. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 14 :397–400.
-
8
Jenkins JM, Hatz C, 1992. The use of diagnostic ultrasound in schistosomiasis: attempts at standardization of methodology. Acta Trop 51 :45–63.
-
9
Qian LH, Wang X, Yang SM, Xu M, 1998. Detecting peripheral blood T lymphocyte immuno-phenotype from patient suffered syphilis by flow cytometry. Chinese J Dermatol 3 :12–18.
-
10
Qiao XT, Dai JZ, 1999. Measurement of peripheral blood T cells in the subset of patients with schistosomiasis after praziquantel therapy. Chinese J Parasit Dis Control 12 :133–134.
-
11
Zhai Z, Zou Y, Wang X, 2002. Determination of serum thyroid hormone and immunoglobulin in subacute thyroiditis. Shanghai J Med Lab Sci 17 :85–88.
-
12
Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G, 1986. Immune responses during human schistosomiasis. XII. Differential responses in patients with hepatosplenic disease. Am J Trop Med Hyg 35 :793–802.
-
13
Li ZS, 1998. Bio-immunity parameters and its clinical values in the patients with advanced schistosomiasis. Chinese J Schistosomiasis Control 10 :369–371.
-
14
Stadecker MJ, Asahi H, Finger E, Hernandez HJ, Rutitzky LI, Sun J, 2004. The immunobiology of Th1 polarization in high-pathology schistosomiasis. Immunol Rev 201 :168–179.
-
15
Mwinzi PNM, Karanja DM, Kareko I, Magak PW, Orago ASS, Colley DG, Secor WE, 2004. Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1. Am J Trop Med Hyg 71 :783–786.
-
16
Chenue SW, 1993. Evolving T cell responses in murine schistosomiasis. Immunology 51 :1391–1396.
-
17
Wang WS, Li YL, 2000. The relationship between immunosuppression phenomenon and T cells apotosis in S. japonicum infection. Chinese J Schistosomiasis Control 12 :257–260.
-
18
Wang WS, Li YL, 2001. The reseach for relative gene transcription level of host CD4+CD8+ T cells apotosis in the S. japonicum infection process. Chinese J Schistosomiasis Control 13 :14–16.
-
19
Liu P, Liu C, Zhang LB, 1989. Immnopotency change of patients with schistosomiasis in fibrosis. Chinese J Int Med 28 :48–49.
-
20
Zeng LL, Li ZJ, Luo DD, 1998. Position observation for T cells sub-class in liver, spleen from patients with schistosomiasis in advanced stage. Chinese J Schistosomiasis Control 10 :145–147.
-
21
Wu XZ, Song CC, Liu SX, 1987. The influence by metabolite origining from worm on mice immnoresponse infected S. japonicum.Chinese J Parasitol Parasitic Dis 5 :127–129.
-
22
Chiaramonte MG, Donaldson DD, Cheever AW, 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflamatory response. J Clin Invest 104 :777–785.
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CD4+ T-CELL COUNTS, CD4+/CD8+ T-CELL COUNT RATIOS, AND ANTIBODY LEVELS IN MIGRANT FISHERMEN INFECTED WITH SCHISTOSOMA JAPONICUM IN THE DONGTING LAKE, CHINA
YUESHENG LI
YUESHENG LI
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake Region, Yueyang, Hunan Province, People’s Republic of China; Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
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QINREN ZENG
QINREN ZENG
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake Region, Yueyang, Hunan Province, People’s Republic of China; Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
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MAGDA K. ELLIS
MAGDA K. ELLIS
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake Region, Yueyang, Hunan Province, People’s Republic of China; Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
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TIE XIONG
TIE XIONG
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake Region, Yueyang, Hunan Province, People’s Republic of China; Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
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JULIE BALEN
JULIE BALEN
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake Region, Yueyang, Hunan Province, People’s Republic of China; Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
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DONALD P. MCMANUS
DONALD P. MCMANUS
Molecular Parasitology Laboratory, Australian Centre for International and Tropical Health and Nutrition, The University of Queensland and The Queensland Institute of Medical Research, Brisbane, Queensland, Australia; Hunan Institute of Parasitic Diseases, WHO Collaborating Centre for Research and Control on Schistosomiasis in Lake Region, Yueyang, Hunan Province, People’s Republic of China; Xiangya School of Medicine, Central South University, Changsha, Hunan, People’s Republic of China
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In this study, CD4+ and CD8+ T cells and antibody levels were measured in 94 migrant fishermen infected with Schistosoma japonicum from Dongting Lake, China. Prevalence among these fishermen was high (63.8%), with a mean infection intensity of 61.4 ± 3.8 epg, and included a high proportion of individuals (39.4%) with substantial parenchymal fibrosis (stages ≥ 2/3). The CD4+/CD8+ ratio in men (1.34 ± 0.11) was significantly lower than that of women (1.58 ± 0.15). CD4+ T cells and the ratio of CD4+/CD8+ were significantly decreased both in subjects infected with S. japonicum and those with parenchymal fibrosis. However, levels of total IgA, IgM, and anti-schistosome egg antigen IgG correlated positively with infection intensity and pathologic lesion number. These results suggest an imbalance between cell-mediated and humoral immunity in these fishermen, the precise cause of which remains undetermined.
Author Notes
- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Profiles of S. japonicum infection and morbidity assessed by ultrasound.
- CD4+T cells, CD4+/CD8+ T-cell count ratios and antibody levels in fishermen compared with naïve controls.
- Implications of CD4+, CD4+/CD8+ T-cell ratios, and antibodies in infection and intensity of infection with S. japonicum.
- CD4+ T cells, CD4+/CD8 + T-cell ratios, and antibodies in liver parenchymal fibrosis subjects detected by ultrasound.
- DISCUSSION
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Stavitsky AB, 2004. Regulation of granulomatous inflammation in experimental models of schistosomiasis. Infect Immun 72 :1–12.
-
2
Cottrell BJ, Humber D, Sturrock RF, 1980. An immunosupressive factor in the serum of patients with schistosomiasis. Trans R Soc Trop Med Hyg 74 :415–416.
-
3
Li HZ, Cai WM, 1991. Preliminary study on peripheral blood T cell subset and B lymphocyte from patients in advanced stage of schistosomiasis. Chinese J Schistosomiasis Control 3 :282–283.
-
4
Li ZJ, Yang Q, Yang XY, 1992. The relationship between IL-1 and changes of peripheral blood T cells sub-class from patients with schistosomiasis. Chinese J Parasit Dis Control 5 :202–203.
-
5
Lin RP, 1994. Clinical value of testing peripheral blood lymphocyte subjet of patients with chronic schistosomiasis. J Pract Parasitic Dis 2 :31–33.
-
6
Li YS, He YK, Zeng QR, McManus DP, 2003. Epidemiological and morbidity assessment of Schistosoma japonicum infection in a migrant fisherman community, the Dongting Lake region, China. Trans R Soc Trop Med Hyg 97 :177–181.
-
7
Katz N, Caves A, Pelegrina J, 1972. A simple device for quantitative stool thick-smear technique in schistosomiasis mansoni. Rev Inst Med Trop Sao Paulo 14 :397–400.
-
8
Jenkins JM, Hatz C, 1992. The use of diagnostic ultrasound in schistosomiasis: attempts at standardization of methodology. Acta Trop 51 :45–63.
-
9
Qian LH, Wang X, Yang SM, Xu M, 1998. Detecting peripheral blood T lymphocyte immuno-phenotype from patient suffered syphilis by flow cytometry. Chinese J Dermatol 3 :12–18.
-
10
Qiao XT, Dai JZ, 1999. Measurement of peripheral blood T cells in the subset of patients with schistosomiasis after praziquantel therapy. Chinese J Parasit Dis Control 12 :133–134.
-
11
Zhai Z, Zou Y, Wang X, 2002. Determination of serum thyroid hormone and immunoglobulin in subacute thyroiditis. Shanghai J Med Lab Sci 17 :85–88.
-
12
Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G, 1986. Immune responses during human schistosomiasis. XII. Differential responses in patients with hepatosplenic disease. Am J Trop Med Hyg 35 :793–802.
-
13
Li ZS, 1998. Bio-immunity parameters and its clinical values in the patients with advanced schistosomiasis. Chinese J Schistosomiasis Control 10 :369–371.
-
14
Stadecker MJ, Asahi H, Finger E, Hernandez HJ, Rutitzky LI, Sun J, 2004. The immunobiology of Th1 polarization in high-pathology schistosomiasis. Immunol Rev 201 :168–179.
-
15
Mwinzi PNM, Karanja DM, Kareko I, Magak PW, Orago ASS, Colley DG, Secor WE, 2004. Short report: Evaluation of hepatic fibrosis in persons co-infected with Schistosoma mansoni and human immunodeficiency virus 1. Am J Trop Med Hyg 71 :783–786.
-
16
Chenue SW, 1993. Evolving T cell responses in murine schistosomiasis. Immunology 51 :1391–1396.
-
17
Wang WS, Li YL, 2000. The relationship between immunosuppression phenomenon and T cells apotosis in S. japonicum infection. Chinese J Schistosomiasis Control 12 :257–260.
-
18
Wang WS, Li YL, 2001. The reseach for relative gene transcription level of host CD4+CD8+ T cells apotosis in the S. japonicum infection process. Chinese J Schistosomiasis Control 13 :14–16.
-
19
Liu P, Liu C, Zhang LB, 1989. Immnopotency change of patients with schistosomiasis in fibrosis. Chinese J Int Med 28 :48–49.
-
20
Zeng LL, Li ZJ, Luo DD, 1998. Position observation for T cells sub-class in liver, spleen from patients with schistosomiasis in advanced stage. Chinese J Schistosomiasis Control 10 :145–147.
-
21
Wu XZ, Song CC, Liu SX, 1987. The influence by metabolite origining from worm on mice immnoresponse infected S. japonicum.Chinese J Parasitol Parasitic Dis 5 :127–129.
-
22
Chiaramonte MG, Donaldson DD, Cheever AW, 1999. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflamatory response. J Clin Invest 104 :777–785.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 23 | 23 | 8 |
| Full Text Views | 231 | 72 | 1 |
| PDF Downloads | 49 | 23 | 0 |