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RefWorks
Reference Manager
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-
1
Desjeux P, 1996. Leishmaniasis. Public health aspects and control. Clin Dermatol 14 :417–423.
-
2
Southgate BA, Manson-Bahr PE, 1967. Studies in the epidemiology of East African leishmaniasis. 4. The significance of the positive leishmanin test. J Trop Med Hyg 70 :29–33.
-
3
Badaro R, Jones TC, Carvalho EM, Sampaio D, Reed SG, Barral A, Teixeira R, Johnson WD Jr, 1986. New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 154 :1003–1011.
-
4
Badaro R, Jones TC, Lorenco R, Cerf BJ, Sampaio D, Carvalho EM, Rocha H, Teixeira R, Johnson WD Jr, 1986. A prospective study of visceral leishmaniasis in an endemic area of Brazil. J Infect Dis 154 :639–649.
-
5
Zijlstra EE, El-Hassan AM, Ismael A, Ghalib HW, 1994. Endemic kala-azar in eastern Sudan: A longitudinal study on the incidence of clinical and subclinical infection and post-kala-azar dermal leishmaniasis. Am J Trop Med Hyg 51 :826–836.
-
6
Pearson RD, Sousa AQ, 1996. Clinical spectrum of Leishmaniasis. Clin Infect Dis 22 :1–13.
-
7
Zijlstra EE, Musa AM, Khalil EA, el-Hassan IM, El-Hassan AM, 2003. Post-kala-azar dermal leishmaniasis. Lancet Infect Dis 3 :87–98.
-
8
de Brito T, Hoshino-Shimizu S, Neto VA, Duarte IS, Penna DO, 1975. Glomerular involvement in human kala-azar. A light, immunofluorescent, and electron microscopic study based on kidney biopsies. Am J Trop Med Hyg 24 :9–18.
-
9
Caravaca F, Munoz A, Pizarro JL, Saez de SJ, Fernandez-Alonso J, 1991. Acute renal failure in visceral leishmaniasis. Am J Nephrol 11 :350–352.
-
10
Marcussen N, Vetner M, Kristensen HM, 1989. Interstitial nephritis and glomerulonephritis in visceral leishmaniasis in a dog. A case report. APMIS 97 :1137–1140.
-
11
Weisinger JR, Pinto A, Velazquez GA, Bronstein I, Dessene JJ, Duque JF, Montenegro J, Tapanes F, de Rousse AR, 1978. Clinical and histological kidney involvement in human kala-azar. Am J Trop Med Hyg 27 :357–359.
-
12
Abreu-Silva AL, Calabrese KS, Cupolilo SM, Cardoso FO, Souza CS, Goncalves da Costa SC, 2004. Histopathological studies of visceralized Leishmania (Leishmania) amazonensis in mice experimentally infected. Vet Parasitol 121 :179–187.
-
13
Tafuri WL, de Oliveira MR, Melo MN, Tafuri WL, 2001. Canine visceral leishmaniosis: A remarkable histopathological picture of one case reported from Brazil. Vet Parasitol 96 :203–212.
-
14
Dutra M, Martinelli R, de Carvalho EM, Rodrigues LE, Brito E, Rocha H, 1985. Renal involvement in visceral leishmaniasis. Am J Kidney Dis 6 :22–27.
-
15
Leblond V, Beaufils H, Ginsburg C, Bricaire F, Danis M, Deray G, Jacobs C, 1994. Collapsing focal segmental glomerulosclerosis associated with visceral leishmaniasis. Nephrol Dial Transplant 9 :1353.
-
16
Duarte MI, Silva MR, Goto H, Nicodemo EL, Amato N, V, 1983. Interstitial nephritis in human kala-azar. Trans R Soc Trop Med Hyg 77 :531–7.
-
17
Jain A, Berthwal M, Tiwari V, Maitra SC, 2000. Immune complex mediated lesions in experimental Kala azar: An ultrastructural study. Indian J Pathol Microbiol 43 :13–16.
-
18
Sartori A, De Oliveira AV, Roque-Barreira MC, Rossi MA, Campos-Neto A, 1987. Immune complex glomerulonephritis in experimental kala-azar. Parasite Immunol 9 :93–103.
-
19
Simonsen O, Grubb A, Thysell H, 1985. The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate. Scand J Clin Lab Invest 45 :97–101.
-
20
Randers E, Kristensen JH, Erlandsen EJ, Danielsen H, 1998. Serum cystatin C as a marker of the renal function. Scand J Clin Lab Invest 58 :585–592.
-
21
Grubb A, 1992. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 38 (Suppl 1):S20–S27.
-
22
Coll E, Botey A, Alvarez L, Poch E, Quinto L, Saurina A, Vera M, Piera C, Darnell A, 2000. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis 36 :29–34.
-
23
Hoogstraal H, Heyneman D, 1969. Leishmaniasis in the Sudan Republic. 30. Final report. Am J Trop Med Hyg 18 :1091–1210.
-
24
Ronnelid J, Tejde A, Mathsson L, Nilsson-Ekdahl K, Nilsson B, 2003. Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE. Ann Rheum Dis 62 :37–42.
-
25
Mathsson L, Tejde A, Carlson K, Hoglund M, Nilsson B, Nilsson-Ekdahl K, Ronnelid J, 2005. Cryoglobulin-induced cytokine production via FcgammaRIIa: inverse effects of complement blockade on the production of TNF-alpha and IL-10. Implications for the growth of malignant B-cell clones. Br J Haematol 129 :830–838.
-
26
Zijlstra EE, El-Hassan AM, 2001. Leishmaniasis in Sudan. Visceral leishmaniasis. Trans R Soc Trop Med Hyg 95 (Suppl 1):S27–S58.
-
27
Bishop ML, Duben-Engelkirk JL, Fody EP, 2000. Clinical Chemistry, Principles, Procedures, Correlations. Philadelphia, PA: Lippincott Williams & Wilkins.
-
28
Oliveira AV, Rossi MA, Rogue-Barreira MC, Sartori A, Campos-Neto A, 1985. The potential role of Leishmania antigens and immunoglobulins in the pathogenesis of glomerular lesions of hamsters infected with Leishmania donovani.Ann Trop Med Parasitol 79 :539–543.
-
29
Sartori A, Roque-Barreira MC, Coe J, Campos-Neto A, 1992. Immune complex glomerulonephritis in experimental kala-azar. II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters. Clin Exp Immunol 87 :386–392.
-
30
Mancianti F, Poli A, Bionda A, 1989. Analysis of renal immune-deposits in canine leishmaniasis. Preliminary results. Parassitologia 31 :213–230.
-
31
Poli A, Abramo F, Mancianti F, Nigro M, Pieri S, Bionda A, 1991. Renal involvement in canine leishmaniasis. A light-microscopic, immunohistochemical and electron-microscopic study. Nephron 57 :444–452.
-
32
Lopez R, Lucena R, Novales M, Ginel PJ, Martin E, Molleda JM, 1996. Circulating immune complexes and renal function in canine leishmaniasis. Zentralbl Veterinarmed B 43 :469–474.
-
33
Kitching AR, Ru H, Turner X, Tipping AL, Dunn PG, Holdsworth AR Sr, 2002. The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. J Am Soc Nephrol 13 :350–358.
-
34
Frank J, Engler-Blum G, Rodemann HP, Muller GA, 1993. Human renal tubular cells as a cytokine source: PDGF-B, GM-CSF and IL-6 mRNA expression in vitro. Exp Nephrol 1 :26–35.
-
35
Miles SA, Conrad SM, Alves RG, Jeronimo SM, Mosser DM, 2005. A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. J Exp Med 201 :747–754.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 237 | 179 | 8 |
| Full Text Views | 232 | 7 | 0 |
| PDF Downloads | 46 | 8 | 0 |
CYSTATIN C AS A MARKER OF IMMUNE COMPLEX–ASSOCIATED RENAL IMPAIRMENT IN A SUDANESE POPULATION WITH VISCERAL LEISHMANIASIS
AMIR IBRAHIM ELSHAFIE
AMIR IBRAHIM ELSHAFIE
Department of Clinical Pathology and Microbiology, Alribat University Hospital, Khartoum, Sudan; Department of Immunology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia; Department of Microbiology and Immunology, University of Khartoum, Khartoum, Sudan; Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala, Sweden; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
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GEHAD ELGHAZALI
GEHAD ELGHAZALI
Department of Clinical Pathology and Microbiology, Alribat University Hospital, Khartoum, Sudan; Department of Immunology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia; Department of Microbiology and Immunology, University of Khartoum, Khartoum, Sudan; Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala, Sweden; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
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JOHAN RÖNNELID
JOHAN RÖNNELID
Department of Clinical Pathology and Microbiology, Alribat University Hospital, Khartoum, Sudan; Department of Immunology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia; Department of Microbiology and Immunology, University of Khartoum, Khartoum, Sudan; Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala, Sweden; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
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PER VENGE
PER VENGE
Department of Clinical Pathology and Microbiology, Alribat University Hospital, Khartoum, Sudan; Department of Immunology, King Fahad Medical City, Riyadh, Kingdom of Saudi Arabia; Department of Microbiology and Immunology, University of Khartoum, Khartoum, Sudan; Department of Oncology, Radiology and Clinical Immunology, University of Uppsala, Uppsala, Sweden; Department of Medical Sciences, University of Uppsala, Uppsala, Sweden
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Renal function was studied in visceral leishmaniasis (VL) and post-kala-azar dermal leishmaniasis (PKDL) by means of the specific marker cystatin C and related to circulating immune complexes and cytokine production. Forty patients with VL (23 with sub-acute disease and 17 with acute disease), 17 patients with PKDL, and 22 healthy controls were included. Cystatin C, but not creatinine, was significantly raised in VL (P = 0.004). The highest levels of cystatin C were found in those with acute disease (P < 0.0001). In VL, cystatin C levels were positively correlated to circulating immune complexes and production of granulocyte-macrophage colony stimulating factor (GM-CSF), but negatively correlated to aspartate aminotransferase and lactate dehydrogenase. We conclude that cystatin C is a superior marker of glomerular function in leishmaniasis and that immune complex deposition and GM-CSF are two functions that most likely are causally involved in the mechanisms leading to glomerular dysfunction in leishmaniasis.
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-
1
Desjeux P, 1996. Leishmaniasis. Public health aspects and control. Clin Dermatol 14 :417–423.
-
2
Southgate BA, Manson-Bahr PE, 1967. Studies in the epidemiology of East African leishmaniasis. 4. The significance of the positive leishmanin test. J Trop Med Hyg 70 :29–33.
-
3
Badaro R, Jones TC, Carvalho EM, Sampaio D, Reed SG, Barral A, Teixeira R, Johnson WD Jr, 1986. New perspectives on a subclinical form of visceral leishmaniasis. J Infect Dis 154 :1003–1011.
-
4
Badaro R, Jones TC, Lorenco R, Cerf BJ, Sampaio D, Carvalho EM, Rocha H, Teixeira R, Johnson WD Jr, 1986. A prospective study of visceral leishmaniasis in an endemic area of Brazil. J Infect Dis 154 :639–649.
-
5
Zijlstra EE, El-Hassan AM, Ismael A, Ghalib HW, 1994. Endemic kala-azar in eastern Sudan: A longitudinal study on the incidence of clinical and subclinical infection and post-kala-azar dermal leishmaniasis. Am J Trop Med Hyg 51 :826–836.
-
6
Pearson RD, Sousa AQ, 1996. Clinical spectrum of Leishmaniasis. Clin Infect Dis 22 :1–13.
-
7
Zijlstra EE, Musa AM, Khalil EA, el-Hassan IM, El-Hassan AM, 2003. Post-kala-azar dermal leishmaniasis. Lancet Infect Dis 3 :87–98.
-
8
de Brito T, Hoshino-Shimizu S, Neto VA, Duarte IS, Penna DO, 1975. Glomerular involvement in human kala-azar. A light, immunofluorescent, and electron microscopic study based on kidney biopsies. Am J Trop Med Hyg 24 :9–18.
-
9
Caravaca F, Munoz A, Pizarro JL, Saez de SJ, Fernandez-Alonso J, 1991. Acute renal failure in visceral leishmaniasis. Am J Nephrol 11 :350–352.
-
10
Marcussen N, Vetner M, Kristensen HM, 1989. Interstitial nephritis and glomerulonephritis in visceral leishmaniasis in a dog. A case report. APMIS 97 :1137–1140.
-
11
Weisinger JR, Pinto A, Velazquez GA, Bronstein I, Dessene JJ, Duque JF, Montenegro J, Tapanes F, de Rousse AR, 1978. Clinical and histological kidney involvement in human kala-azar. Am J Trop Med Hyg 27 :357–359.
-
12
Abreu-Silva AL, Calabrese KS, Cupolilo SM, Cardoso FO, Souza CS, Goncalves da Costa SC, 2004. Histopathological studies of visceralized Leishmania (Leishmania) amazonensis in mice experimentally infected. Vet Parasitol 121 :179–187.
-
13
Tafuri WL, de Oliveira MR, Melo MN, Tafuri WL, 2001. Canine visceral leishmaniosis: A remarkable histopathological picture of one case reported from Brazil. Vet Parasitol 96 :203–212.
-
14
Dutra M, Martinelli R, de Carvalho EM, Rodrigues LE, Brito E, Rocha H, 1985. Renal involvement in visceral leishmaniasis. Am J Kidney Dis 6 :22–27.
-
15
Leblond V, Beaufils H, Ginsburg C, Bricaire F, Danis M, Deray G, Jacobs C, 1994. Collapsing focal segmental glomerulosclerosis associated with visceral leishmaniasis. Nephrol Dial Transplant 9 :1353.
-
16
Duarte MI, Silva MR, Goto H, Nicodemo EL, Amato N, V, 1983. Interstitial nephritis in human kala-azar. Trans R Soc Trop Med Hyg 77 :531–7.
-
17
Jain A, Berthwal M, Tiwari V, Maitra SC, 2000. Immune complex mediated lesions in experimental Kala azar: An ultrastructural study. Indian J Pathol Microbiol 43 :13–16.
-
18
Sartori A, De Oliveira AV, Roque-Barreira MC, Rossi MA, Campos-Neto A, 1987. Immune complex glomerulonephritis in experimental kala-azar. Parasite Immunol 9 :93–103.
-
19
Simonsen O, Grubb A, Thysell H, 1985. The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate. Scand J Clin Lab Invest 45 :97–101.
-
20
Randers E, Kristensen JH, Erlandsen EJ, Danielsen H, 1998. Serum cystatin C as a marker of the renal function. Scand J Clin Lab Invest 58 :585–592.
-
21
Grubb A, 1992. Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 38 (Suppl 1):S20–S27.
-
22
Coll E, Botey A, Alvarez L, Poch E, Quinto L, Saurina A, Vera M, Piera C, Darnell A, 2000. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis 36 :29–34.
-
23
Hoogstraal H, Heyneman D, 1969. Leishmaniasis in the Sudan Republic. 30. Final report. Am J Trop Med Hyg 18 :1091–1210.
-
24
Ronnelid J, Tejde A, Mathsson L, Nilsson-Ekdahl K, Nilsson B, 2003. Immune complexes from SLE sera induce IL10 production from normal peripheral blood mononuclear cells by an FcgammaRII dependent mechanism: implications for a possible vicious cycle maintaining B cell hyperactivity in SLE. Ann Rheum Dis 62 :37–42.
-
25
Mathsson L, Tejde A, Carlson K, Hoglund M, Nilsson B, Nilsson-Ekdahl K, Ronnelid J, 2005. Cryoglobulin-induced cytokine production via FcgammaRIIa: inverse effects of complement blockade on the production of TNF-alpha and IL-10. Implications for the growth of malignant B-cell clones. Br J Haematol 129 :830–838.
-
26
Zijlstra EE, El-Hassan AM, 2001. Leishmaniasis in Sudan. Visceral leishmaniasis. Trans R Soc Trop Med Hyg 95 (Suppl 1):S27–S58.
-
27
Bishop ML, Duben-Engelkirk JL, Fody EP, 2000. Clinical Chemistry, Principles, Procedures, Correlations. Philadelphia, PA: Lippincott Williams & Wilkins.
-
28
Oliveira AV, Rossi MA, Rogue-Barreira MC, Sartori A, Campos-Neto A, 1985. The potential role of Leishmania antigens and immunoglobulins in the pathogenesis of glomerular lesions of hamsters infected with Leishmania donovani.Ann Trop Med Parasitol 79 :539–543.
-
29
Sartori A, Roque-Barreira MC, Coe J, Campos-Neto A, 1992. Immune complex glomerulonephritis in experimental kala-azar. II: Detection and characterization of parasite antigens and antibodies eluted from kidneys of Leishmania donovani-infected hamsters. Clin Exp Immunol 87 :386–392.
-
30
Mancianti F, Poli A, Bionda A, 1989. Analysis of renal immune-deposits in canine leishmaniasis. Preliminary results. Parassitologia 31 :213–230.
-
31
Poli A, Abramo F, Mancianti F, Nigro M, Pieri S, Bionda A, 1991. Renal involvement in canine leishmaniasis. A light-microscopic, immunohistochemical and electron-microscopic study. Nephron 57 :444–452.
-
32
Lopez R, Lucena R, Novales M, Ginel PJ, Martin E, Molleda JM, 1996. Circulating immune complexes and renal function in canine leishmaniasis. Zentralbl Veterinarmed B 43 :469–474.
-
33
Kitching AR, Ru H, Turner X, Tipping AL, Dunn PG, Holdsworth AR Sr, 2002. The requirement for granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in leukocyte-mediated immune glomerular injury. J Am Soc Nephrol 13 :350–358.
-
34
Frank J, Engler-Blum G, Rodemann HP, Muller GA, 1993. Human renal tubular cells as a cytokine source: PDGF-B, GM-CSF and IL-6 mRNA expression in vitro. Exp Nephrol 1 :26–35.
-
35
Miles SA, Conrad SM, Alves RG, Jeronimo SM, Mosser DM, 2005. A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. J Exp Med 201 :747–754.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 237 | 179 | 8 |
| Full Text Views | 232 | 7 | 0 |
| PDF Downloads | 46 | 8 | 0 |