ProCite
RefWorks
Reference Manager
BibTeX
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-
1
Lohoff M, Gessner A, Bogdan C, Röllinghoff M, 1998. The Th1/Th2 paradigm and experimental murine leishmaniasis. Int Arch Allergy Immunol 115 :191–202.
-
2
Solbach W, Laskay T, 2000. The host response to Leishmania infection. Adv Immunol 74 :275–317.
-
3
Alexander J, Bryson K, 2005. T helper (h)1/Th2 and Leishmania: Paradox rather than paradigm. Immunol Lett 99 :17–23.
-
4
Brown DR, Reiner SL, 1999. Polarized helper-T-cell responses against Leishmania major in the absence of B cells. Infect Immun 67 :266–270.
-
5
Huber M, Timms E, Mak TW, Rollinghoff M, Lohoff M, 1998. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun 66 :3968–3970.
-
6
Safe SS, 1990. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors. Crit Rev Toxicol 21 :51–88.
-
7
Zook DR, Rappe C, 1994. Environmental sources, distribution, and fate of polychlorinated dibenzodioxins, dibenzofurans, and related organochlorines. Schecter A, ed. Dioxins and Health. New York: Plenum Press.
-
8
Birnbaum LS, Tuomisto J, 2000. Non-carcinogenic effects of TCDD in animals. Food Addit Contam 17 :275–288.
-
9
Kerkvliet NI, 1995. Immunological effects of chlorinated dibenzo-p-dioxins. Environ Health Perspect 103 (Suppl 9):47–53.
-
10
Vorderstrasse BA, Steppan LB, Silverstone AE, Kerkvliet NI, 2001. Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression. Toxicol Appl Pharmacol 171 :157–164.
-
11
Jeon MS, Esser C, 2000. The murine IL-2 promoter contains distal regulatory elements reponsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. J Immunol 165 :6975–6983.
-
12
Kamath AB, Camacho I, Nagarkatti PS, Nagarkatti M, 1999. Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity: increased resistance of thymocytes from Fas-deficient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicity. Toxicol Appl Pharmacol 160 :141–155.
-
13
Prell RA, Kerkvliet NI, 1997. Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma. J Immunol 158 :2695–2703.
-
14
Kerkvliet NI, Baecher-Steppan L, Shepherd DM, Oughton JA, Vorderstrasse BA, DeKrey GK, 1996. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol 157 :2310–2319.
-
15
Titus RG, Ceredig R, Cerottini JC, Louis JA, 1985. Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J Immunol 135 :2108–2114.
-
16
Yang DM, Fairweather N, Button LL, McMaster WR, Kahl LP, Liew FY, 1990. Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis. J Immunol 145 :2281–2285.
-
17
Lima HC, Bleyenberg JA, Titus RG, 1997. A simple method for quantifying Leishmania in tissues of infected animals. Parasitol Today 13 :80–83.
-
18
Warren TK, Mitchell KA, Lawrence BP, 2000. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses the humoral and cell-mediated responses to influenza A virus without affecting cytolytic activity in the lung. Toxicol Sci 56 :114–123.
-
19
Shepherd DM, Dearstyne EA, Kerkvliet NI, 2000. The effects of TCDD on the activation of ovalbumin (OVA)-specific DO11.10 transgenic CD4+ T cells in adoptively transferred mice. Toxicol Sci 56 :340–350.
-
20
Ito T, Inouye K, Fujimaki H, Tohyama C, Nohara K, 2002. Mechanism of TCDD-induced suppression of antibody production: Effect on T cell-derived cytokine production in the primary immune reaction of mice. Toxicol Sci 70 :46–54.
-
21
Chakkalath HR, Titus RG, 1994. Leishmania major-parasitized macrophages augment Th2-type T cell activation. J Immunol 153 :4378–4387.
-
22
Mbow ML, DeKrey GK, Titus RG, 2001. Leishmania major induces differential expression of costimulatory molecules on mouse epidermal cells. Eur J Immunol 31 :1400–1409.
-
23
Alsharif NZ, Schlueter WJ, Stohs SJ, 1994. Stimulation of NADPH-dependent reactive oxygen species formation and DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat peritoneal lavage cells. Arch Environ Contam Toxicol 26 :392.
-
24
Alsharif NZ, Lawson T, Stohs SJ, 1994. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by the aryl hydrocarbon (Ah) receptor complex. Toxicology 92 :39–51.
-
25
Kerkvliet NI, Oughton JA, 1993. Acute inflammatory response to sheep red blood cell challenge in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): phenotypic and functional analysis of peritoneal exudate cells. Toxicol Appl Pharmacol 119 :248–257.
-
26
Taylor MJ, Lucier GW, Mahler JF, Thompson M, Lockhart AC, Clark GC, 1992. Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol Appl Pharmacol 117 :126–132.
-
27
van Grevenynghe J, Sparfel L, Le Vee M, Gilot D, Drenou B, Fauchet R, Fardel O, 2004. Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Biochem Biophys Res Commun 317 :708–716.
-
28
Mantovani A, Vecchi A, Luini W, Sironi M, Candiani GP, Spreafico F, Garattini S, 1980. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on macrophage and natural killer cell mediated cytotoxicity in mice. Biomedicine 32 :200–204.
-
29
Vos JG, Kreeftenberg JG, Engel HWB, Minderhoud A, Van Noorle Jansen LM, 1978. Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immune suppression and decreased resistance to infection: Endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatment. Toxicology 9 :75–86.
-
30
Nacy CA, Meierovies AI, Belosevic M, Green SJ, 1991. Tumor necrosis factor-alpha: Central regulatory cytokine in the induction of macrophage antimicrobial activities. Pathobiology 59 :182–184.
-
31
Kerkvliet NI, Oughton JA, 1993. Acute inflammatory response to sheep red blood cell challenge in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Phenotypic and functional analysis of peritoneal exudate cells. Toxicol Appl Pharmacol 119 :248–257.
-
32
Taylor MJ, Lucier GW, Mahler JF, Thompson M, Lockhart AC, Clark GC, 1992. Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol Appl Pharmacol 117 :126–132.
-
33
Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y, 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67 :89–93.
-
34
Tucker AN, Vore SJ, Luster MI, 1986. Suppression of B cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 29 :372–377.
-
35
Hahn ME, 2002. Aryl hydrocarbon receptors: Diversity and evolution. Chem Biol Interact 141 :131–160.
-
36
Birnbaum LS, 1986. Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus. Drug Metab Dispos 14 :34–40.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 702 | 654 | 291 |
| Full Text Views | 218 | 4 | 0 |
| PDF Downloads | 52 | 4 | 0 |
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) REDUCES LEISHMANIA MAJOR BURDENS IN C57BL/6 MICE
OWEN J. BOWERS
OWEN J. BOWERS
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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KIRSA B. SOMMERSTED
KIRSA B. SOMMERSTED
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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RYAN T. SOWELL
RYAN T. SOWELL
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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GRETCHEN E. BOLING
GRETCHEN E. BOLING
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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WILLIAM H. HANNEMAN
WILLIAM H. HANNEMAN
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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RICHARD G. TITUS
RICHARD G. TITUS
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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GREGORY K. DEKREY
GREGORY K. DEKREY
Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, Colorado; Department of Biological Sciences, College of Natural and Health Sciences, University of Northern Colorado, Greeley, Colorado; Department of Immunology, University of Texas, Graduate School of Biomedical Sciences at Houston, Houston, Texas; Department of Environmental and Radiological Health Sciences and Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado
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Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major–infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.
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-
1
Lohoff M, Gessner A, Bogdan C, Röllinghoff M, 1998. The Th1/Th2 paradigm and experimental murine leishmaniasis. Int Arch Allergy Immunol 115 :191–202.
-
2
Solbach W, Laskay T, 2000. The host response to Leishmania infection. Adv Immunol 74 :275–317.
-
3
Alexander J, Bryson K, 2005. T helper (h)1/Th2 and Leishmania: Paradox rather than paradigm. Immunol Lett 99 :17–23.
-
4
Brown DR, Reiner SL, 1999. Polarized helper-T-cell responses against Leishmania major in the absence of B cells. Infect Immun 67 :266–270.
-
5
Huber M, Timms E, Mak TW, Rollinghoff M, Lohoff M, 1998. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun 66 :3968–3970.
-
6
Safe SS, 1990. Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors. Crit Rev Toxicol 21 :51–88.
-
7
Zook DR, Rappe C, 1994. Environmental sources, distribution, and fate of polychlorinated dibenzodioxins, dibenzofurans, and related organochlorines. Schecter A, ed. Dioxins and Health. New York: Plenum Press.
-
8
Birnbaum LS, Tuomisto J, 2000. Non-carcinogenic effects of TCDD in animals. Food Addit Contam 17 :275–288.
-
9
Kerkvliet NI, 1995. Immunological effects of chlorinated dibenzo-p-dioxins. Environ Health Perspect 103 (Suppl 9):47–53.
-
10
Vorderstrasse BA, Steppan LB, Silverstone AE, Kerkvliet NI, 2001. Aryl hydrocarbon receptor-deficient mice generate normal immune responses to model antigens and are resistant to TCDD-induced immune suppression. Toxicol Appl Pharmacol 171 :157–164.
-
11
Jeon MS, Esser C, 2000. The murine IL-2 promoter contains distal regulatory elements reponsive to the Ah receptor, a member of the evolutionarily conserved bHLH-PAS transcription factor family. J Immunol 165 :6975–6983.
-
12
Kamath AB, Camacho I, Nagarkatti PS, Nagarkatti M, 1999. Role of Fas-Fas ligand interactions in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced immunotoxicity: increased resistance of thymocytes from Fas-deficient (lpr) and Fas ligand-defective (gld) mice to TCDD-induced toxicity. Toxicol Appl Pharmacol 160 :141–155.
-
13
Prell RA, Kerkvliet NI, 1997. Involvement of altered B7 expression in dioxin immunotoxicity: B7 transfection restores the CTL but not the autoantibody response to the P815 mastocytoma. J Immunol 158 :2695–2703.
-
14
Kerkvliet NI, Baecher-Steppan L, Shepherd DM, Oughton JA, Vorderstrasse BA, DeKrey GK, 1996. Inhibition of TC-1 cytokine production, effector cytotoxic T lymphocyte development and alloantibody production by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol 157 :2310–2319.
-
15
Titus RG, Ceredig R, Cerottini JC, Louis JA, 1985. Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice. J Immunol 135 :2108–2114.
-
16
Yang DM, Fairweather N, Button LL, McMaster WR, Kahl LP, Liew FY, 1990. Oral Salmonella typhimurium (AroA-) vaccine expressing a major leishmanial surface protein (gp63) preferentially induces T helper 1 cells and protective immunity against leishmaniasis. J Immunol 145 :2281–2285.
-
17
Lima HC, Bleyenberg JA, Titus RG, 1997. A simple method for quantifying Leishmania in tissues of infected animals. Parasitol Today 13 :80–83.
-
18
Warren TK, Mitchell KA, Lawrence BP, 2000. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) suppresses the humoral and cell-mediated responses to influenza A virus without affecting cytolytic activity in the lung. Toxicol Sci 56 :114–123.
-
19
Shepherd DM, Dearstyne EA, Kerkvliet NI, 2000. The effects of TCDD on the activation of ovalbumin (OVA)-specific DO11.10 transgenic CD4+ T cells in adoptively transferred mice. Toxicol Sci 56 :340–350.
-
20
Ito T, Inouye K, Fujimaki H, Tohyama C, Nohara K, 2002. Mechanism of TCDD-induced suppression of antibody production: Effect on T cell-derived cytokine production in the primary immune reaction of mice. Toxicol Sci 70 :46–54.
-
21
Chakkalath HR, Titus RG, 1994. Leishmania major-parasitized macrophages augment Th2-type T cell activation. J Immunol 153 :4378–4387.
-
22
Mbow ML, DeKrey GK, Titus RG, 2001. Leishmania major induces differential expression of costimulatory molecules on mouse epidermal cells. Eur J Immunol 31 :1400–1409.
-
23
Alsharif NZ, Schlueter WJ, Stohs SJ, 1994. Stimulation of NADPH-dependent reactive oxygen species formation and DNA damage by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat peritoneal lavage cells. Arch Environ Contam Toxicol 26 :392.
-
24
Alsharif NZ, Lawson T, Stohs SJ, 1994. Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin is mediated by the aryl hydrocarbon (Ah) receptor complex. Toxicology 92 :39–51.
-
25
Kerkvliet NI, Oughton JA, 1993. Acute inflammatory response to sheep red blood cell challenge in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): phenotypic and functional analysis of peritoneal exudate cells. Toxicol Appl Pharmacol 119 :248–257.
-
26
Taylor MJ, Lucier GW, Mahler JF, Thompson M, Lockhart AC, Clark GC, 1992. Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol Appl Pharmacol 117 :126–132.
-
27
van Grevenynghe J, Sparfel L, Le Vee M, Gilot D, Drenou B, Fauchet R, Fardel O, 2004. Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages. Biochem Biophys Res Commun 317 :708–716.
-
28
Mantovani A, Vecchi A, Luini W, Sironi M, Candiani GP, Spreafico F, Garattini S, 1980. Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on macrophage and natural killer cell mediated cytotoxicity in mice. Biomedicine 32 :200–204.
-
29
Vos JG, Kreeftenberg JG, Engel HWB, Minderhoud A, Van Noorle Jansen LM, 1978. Studies on 2,3,7,8-tetrachlorodibenzo-p-dioxin induced immune suppression and decreased resistance to infection: Endotoxin hypersensitivity, serum zinc concentrations and effect of thymosin treatment. Toxicology 9 :75–86.
-
30
Nacy CA, Meierovies AI, Belosevic M, Green SJ, 1991. Tumor necrosis factor-alpha: Central regulatory cytokine in the induction of macrophage antimicrobial activities. Pathobiology 59 :182–184.
-
31
Kerkvliet NI, Oughton JA, 1993. Acute inflammatory response to sheep red blood cell challenge in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): Phenotypic and functional analysis of peritoneal exudate cells. Toxicol Appl Pharmacol 119 :248–257.
-
32
Taylor MJ, Lucier GW, Mahler JF, Thompson M, Lockhart AC, Clark GC, 1992. Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol Appl Pharmacol 117 :126–132.
-
33
Sugita-Konishi Y, Kobayashi K, Naito H, Miura K, Suzuki Y, 2003. Effect of lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin on the susceptibility to Listeria infection. Biosci Biotechnol Biochem 67 :89–93.
-
34
Tucker AN, Vore SJ, Luster MI, 1986. Suppression of B cell differentiation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol Pharmacol 29 :372–377.
-
35
Hahn ME, 2002. Aryl hydrocarbon receptors: Diversity and evolution. Chem Biol Interact 141 :131–160.
-
36
Birnbaum LS, 1986. Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus. Drug Metab Dispos 14 :34–40.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 702 | 654 | 291 |
| Full Text Views | 218 | 4 | 0 |
| PDF Downloads | 52 | 4 | 0 |