• 1

    Hou RF, Tu WC, Lee HH, Chen KM, Chou HL, Lai SC, 2004. Elevation of plasminogen activators in cerebrospinal fluid of mice with eosinophilic meningitis caused by Angiostrongylus cantonensis. Int J Parasitol 34 :1355–1364.

    • Search Google Scholar
    • Export Citation
  • 2

    Beutler B, Cerami A, 1989. The biology of cachectin/TNF: a primary mediator of the host response. Annu Rev Immunol 7 :625–655.

  • 3

    Sarén P, Welgus HG, Kovanen PT, 1996. TNF-α and IL-1β selectively induce expression of 92 kDa gelatinase by human macrophages. J Immunol 157 :4159–4165.

    • Search Google Scholar
    • Export Citation
  • 4

    Pugin J, Widmer MC, Kossodo S, Liang CM, Preas HL, Suffredini AF, 1999. Human neutrophils secrete gelatinase B in vitro and in vivo in response to endotoxin and proinflammatory mediators. Am J Respir Cell Mol Biol 20 :458–464.

    • Search Google Scholar
    • Export Citation
  • 5

    Lan KP, Wang CJ, Lai SC, Chen KM, Lee SS, Hsu JD, Lee HH, 2004. The efficacy of therapy with albendazole in mice with parasitic meningitis caused by Angiostrongylus cantonensis. Parasitol Res 93 :311–317.

    • Search Google Scholar
    • Export Citation
  • 6

    Zhang BZ, Ding F, Tan LW, 1993. Clinical and experimental study on yi-gan-ning granule in treating chronic hepatitis B. Zhongguo Zhong Xi Yi Jie He Za Zhi 13 :597–599.

    • Search Google Scholar
    • Export Citation
  • 7

    Hong SH, Seo SH, Lee JH, Choi BT, 2004. The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-kappa B activation in human hepatoma cell line and rat liver. Int J Mol Med 13 :717–720.

    • Search Google Scholar
    • Export Citation
  • 8

    Meshnick SR, Taylor TE, Kamchonwongpaisan S, 1996. Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiol Rev 60 :301–315.

    • Search Google Scholar
    • Export Citation
  • 9

    Parsons JC, Grieve RB, 1990. Effect of egg dosage and host genotype on liver trapping in murine larval toxocariasis. J Parasitol 76 :53–58.

    • Search Google Scholar
    • Export Citation
  • 10

    Chen KM, Lee HH, Lu KH, Tseng YK, Hsu LS, Chou HL, Lai SC, 2004. Association of matrix metalloproteinase-9 and Purkinje cell degeneration in mouse cerebellum caused by Angiostrongylus cantonensis. Int J Parasitol 34 :1147–1156.

    • Search Google Scholar
    • Export Citation
  • 11

    Betsuyaku T, Fukuda Y, Parks WC, Shipley JM, Senior RM, 2000. Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin. Am J Pathol 157 :525–535.

    • Search Google Scholar
    • Export Citation
  • 12

    Boven LA, Vergnolle N, Henry SD, Silva C, Imai Y, Holden J, Warren K, Hollenberg MD, Power C, 2003. Up-regulation of proteinase-activated receptor 1 expression in astrocytes during HIV encephalitis. J Immunol 170 :2638–2646.

    • Search Google Scholar
    • Export Citation
  • 13

    Aris RM, Walsh S, Chalermskulrat W, Hathwar V, Neuringer IP, 2002. Growth factor upregulation during obliterative bronchiolitis in the mouse model. Am J Respir Crit Care Med 166 :417–422.

    • Search Google Scholar
    • Export Citation
  • 14

    Yeung CY, Leung CS, Chen YZ, 1993. An old traditional herbal remedy for neonatal jaundice with a newly identified risk. J Paediatr Child Health 29 :292–294.

    • Search Google Scholar
    • Export Citation
  • 15

    Ho NK, 1996. Traditional Chinese medicine and treatment of neonatal jaundice. Singapore Med J 37 :645–651.

 
 
 

 

 
 
 

 

 

 

 

 

 

CHINESE HERBAL MEDICINE YIN-CHEN-EXTRACT AS AN ADJUNCT TO ANTHELMINTIC ALBENDAZOLE USED AGAINST ANGIOSTRONGYLUS CANTONENSIS-INDUCED EOSINOPHILIC MENINGITIS OR MENINGOENCEPHALITIS

View More View Less
  • 1 Department of Parasitology, Chung Shan Medical University, Taiwan

The effects of albendazole and Yin-Chen-Extract co-therapy on Angiostrongylus cantonensis-induced eosinophilic meningitis in BALB/c mice were evaluated. Assay indicators for the therapeutic effect include worm recovery, histopathological score of the fourth ventricle, tissue-type plasminogen activator, urokinasetype plasminogen activator, matrix metalloproteinase-9, cerebrospinal fluid total protein, leukocyte counts, and proinflammatory cytokines. As a result, albendazole and Yin-Chen-Extract co-therapy significantly decreased (P < 0.05) these factors. Although Yin-Chen-Extract may possess pharmacologic activities beneficial to the inhibition of parasite-induced inflammation, many of these hypothetical benefits await scientific testing and confirmation before application. This study suggests that the combination of Yin-Chen-Extract and albendazole has synergistic effects in managing eosinophilic meningitis or eosinophilic meningoencephalitis.

Save