CLINICAL FEATURES OF 62 IMPORTED CASES OF DENGUE FEVER IN JAPAN

ICHIRO ITODA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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GOHTA MASUDA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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AKIHIKO SUGANUMA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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AKIFUMI IMAMURA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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ATSUSHI AJISAWA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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KEN-ICHIRO YAMADA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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SADAO YABE Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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TOMOHIKO TAKASAKI Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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ICHIRO KURANE Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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KYOICHI TOTSUKA Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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MASAYOSHI NEGISHI Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Infectious Diseases, Tokyo Women’s Medical University, Tokyo Japan; Department of Virology 1, National Institute of Infectious Diseases, Tokyo, Japan

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DOI:
https://doi.org/10.4269/ajtmh.2006.75.470
Volume/Issue:
Volume 75: Issue 3
Page(s):
470–474
Restricted access
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To describe the clinical features of dengue cases in Japan, a retrospective study was conducted on 62 laboratory-confirmed Japanese dengue cases presented to Tokyo Metropolitan Komagome Hospital between 1985 and 2000. Age distribution was from 18 to 62 years old (mean, 31.5 years). All cases were imported from abroad and diagnosed as dengue fever. Clinical manifestations included fever (100%), headache (90%), and skin rash (82%). Laboratory examinations revealed leukocytopenia (71%), thrombocytopenia (57%), elevated levels of serum aspartate aminotransferase (78%), and lactate dehydrogenase (71%). Antibody responses were consistent with that of secondary flavivirus infection in 60% of cases. Severity of symptoms in patients with primary dengue antibody response and those with secondary flavivirus antibody responses didn’t show statistical significance. Dengue virus infection should be taken into consideration in the differential diagnosis of febrile patients who recently entered Japan from tropical or subtropical countries.

Author Notes

Copyright:
Copyright 2006 The American Society of Tropical Medicine 2006
Received:
04 Nov 2005
|
Accepted:
16 May 2006
|
Published Online:
Sep 2006
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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