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1
Kelton JG, Keystone J, Moore J, Denomme G, Tozman E, Glynn M, Neame PB, Gauldie J, Jensen J, 1983. Immune-mediated thrombocytopenia of malaria. J Clin Invest 71 :832–836.
-
2
Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR, 2002. Changes in white blood cells and platelets in children with falciparum malaria: Relationship to disease outcome. Br J Haematol 119 :839–847.
-
3
Wickramasinghe SN, Abdalla SH, 2000. Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol 13 :277–299.
-
4
van der Heyde HC, Gramaglia I, Sun G, Woods C, 2005. Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines. Blood 105 :1956–1963.
-
5
Grau GE, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME, 2003. Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. J Infect Dis 187 :461–466.
-
6
Pain A, Ferguson DJ, Kai O, Urban BC, Lowe B, Marsh K, Roberts DJ, 2001. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc Natl Acad Sci USA 98 :1805–1810.
-
7
Newton P, Essien E, White NJ, 2004. Platelets and blood coagulation in human malaria. Abdalla SH, Pavol G, eds. Malaria: A Haematological Perspective. London: Imperial College Press, 249–274.
-
8
Kreil A, Wenisch C, Brittenham G, Looareesuwan S, Peck-Radosavljevic M, 2000. Thrombopoietin in Plasmodium falciparum malaria. Br J Haematol 109 :534–536.
-
9
Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R, Winkler S, Pabinger I, Kletter K, 2004. Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemost 91 :553–557.
-
10
Kueh YK, Yeo KL, 1982. Haematological alterations in acute malaria. Scand J Haematol 29 :147–152.
-
11
Knuttgen HJ, 1987. The bone marrow of non-immune Europeans in acute malaria infection: A topical review. Ann Trop Med Parasitol 81 :567–576.
-
12
Abdalla SH, 1990. Hematopoiesis in human malaria. Blood Cells 16 :401–416.
-
13
Tacchini-Cottier F, Vesin C, Redard M, Buurman W, Piguet PF, 1998. Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. J Immunol 160 :6182–6186.
-
14
Sosman JA, Verma A, Moss S, Sorokin P, Blend M, Bradlow B, Chachlani N, Cutler D, Sabo R, Nelson M, Bruno E, Gustin D, Viana M, Hoffman R, 2000. Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: Evidence for decreased platelet production. Br J Haematol 111 :104–111.
-
15
Kurtzhals JA, Adabayeri V, Goka BQ, Akanmori BD, Oliver-Commey JO, Nkrumah FK, Behr C, Hviid L, 1998. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet 351 :1768–1772.
-
16
Snow RW, Omumbo JA, Lowe B, Molyneux CS, Obiero JO, Palmer A, Weber MW, Pinder M, Nahlen B, Obonyo C, Newbold C, Gupta S, Marsh K, 1997. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349 :1650–1654.
-
17
Scaradavou A, 2002. HIV-related thrombocytopenia. Blood Rev 16 :73–76.
-
18
Gerardin P, Rogier C, Ka AS, Jouvencel P, Brousse V, Imbert P, 2002. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 66 :686–691.
| Past two years | Past Year | Past 30 Days | |
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THROMBOCYTOPENIA IN FALCIPARUM MALARIA IS ASSOCIATED WITH HIGH CONCENTRATIONS OF IL-10
CLIMENT CASALS-PASCUAL
CLIMENT CASALS-PASCUAL
Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom; KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya; Neurosciences Unit, Institute for Child Health, London, United Kingdom
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OSCAR KAI
OSCAR KAI
Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom; KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya; Neurosciences Unit, Institute for Child Health, London, United Kingdom
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CHARLES R. J. C. NEWTON
CHARLES R. J. C. NEWTON
Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom; KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya; Neurosciences Unit, Institute for Child Health, London, United Kingdom
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NORBERT PESHU
NORBERT PESHU
Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom; KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya; Neurosciences Unit, Institute for Child Health, London, United Kingdom
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DAVID J. ROBERTS
DAVID J. ROBERTS
Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom; KEMRI Centre for Geographic Medicine Coast, Kilifi, Kenya; Neurosciences Unit, Institute for Child Health, London, United Kingdom
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Over the last decade, a number of observations have suggested that platelets may play a role in the pathophysiology of severe malaria. However, somewhat paradoxically, thrombocytopenia is not associated clearly with outcome. We studied the relationship between thrombocytopenia and cytokines in Kenyan children with severe malaria and showed that thrombocytopenia (platelet count < 150 × 109/L) strongly correlates with high levels of interleukin (IL)-10. Several studies have shown that high levels of IL-10 are associated with a favorable outcome in severe malaria. Taken together, these data suggest why thrombocytopenia has a complex relationship with severe disease and suggest one mechanism whereby IL-10 may modify the outcome of severe disease.
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Reference Manager
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-
1
Kelton JG, Keystone J, Moore J, Denomme G, Tozman E, Glynn M, Neame PB, Gauldie J, Jensen J, 1983. Immune-mediated thrombocytopenia of malaria. J Clin Invest 71 :832–836.
-
2
Ladhani S, Lowe B, Cole AO, Kowuondo K, Newton CR, 2002. Changes in white blood cells and platelets in children with falciparum malaria: Relationship to disease outcome. Br J Haematol 119 :839–847.
-
3
Wickramasinghe SN, Abdalla SH, 2000. Blood and bone marrow changes in malaria. Baillieres Best Pract Res Clin Haematol 13 :277–299.
-
4
van der Heyde HC, Gramaglia I, Sun G, Woods C, 2005. Platelet depletion by anti-CD41 (alphaIIb) mAb injection early but not late in the course of disease protects against Plasmodium berghei pathogenesis by altering the levels of pathogenic cytokines. Blood 105 :1956–1963.
-
5
Grau GE, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME, 2003. Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. J Infect Dis 187 :461–466.
-
6
Pain A, Ferguson DJ, Kai O, Urban BC, Lowe B, Marsh K, Roberts DJ, 2001. Platelet-mediated clumping of Plasmodium falciparum-infected erythrocytes is a common adhesive phenotype and is associated with severe malaria. Proc Natl Acad Sci USA 98 :1805–1810.
-
7
Newton P, Essien E, White NJ, 2004. Platelets and blood coagulation in human malaria. Abdalla SH, Pavol G, eds. Malaria: A Haematological Perspective. London: Imperial College Press, 249–274.
-
8
Kreil A, Wenisch C, Brittenham G, Looareesuwan S, Peck-Radosavljevic M, 2000. Thrombopoietin in Plasmodium falciparum malaria. Br J Haematol 109 :534–536.
-
9
Karanikas G, Zedwitz-Liebenstein K, Eidherr H, Schuetz M, Sauerman R, Dudczak R, Winkler S, Pabinger I, Kletter K, 2004. Platelet kinetics and scintigraphic imaging in thrombocytopenic malaria patients. Thromb Haemost 91 :553–557.
-
10
Kueh YK, Yeo KL, 1982. Haematological alterations in acute malaria. Scand J Haematol 29 :147–152.
-
11
Knuttgen HJ, 1987. The bone marrow of non-immune Europeans in acute malaria infection: A topical review. Ann Trop Med Parasitol 81 :567–576.
-
12
Abdalla SH, 1990. Hematopoiesis in human malaria. Blood Cells 16 :401–416.
-
13
Tacchini-Cottier F, Vesin C, Redard M, Buurman W, Piguet PF, 1998. Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. J Immunol 160 :6182–6186.
-
14
Sosman JA, Verma A, Moss S, Sorokin P, Blend M, Bradlow B, Chachlani N, Cutler D, Sabo R, Nelson M, Bruno E, Gustin D, Viana M, Hoffman R, 2000. Interleukin 10-induced thrombocytopenia in normal healthy adult volunteers: Evidence for decreased platelet production. Br J Haematol 111 :104–111.
-
15
Kurtzhals JA, Adabayeri V, Goka BQ, Akanmori BD, Oliver-Commey JO, Nkrumah FK, Behr C, Hviid L, 1998. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria. Lancet 351 :1768–1772.
-
16
Snow RW, Omumbo JA, Lowe B, Molyneux CS, Obiero JO, Palmer A, Weber MW, Pinder M, Nahlen B, Obonyo C, Newbold C, Gupta S, Marsh K, 1997. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 349 :1650–1654.
-
17
Scaradavou A, 2002. HIV-related thrombocytopenia. Blood Rev 16 :73–76.
-
18
Gerardin P, Rogier C, Ka AS, Jouvencel P, Brousse V, Imbert P, 2002. Prognostic value of thrombocytopenia in African children with falciparum malaria. Am J Trop Med Hyg 66 :686–691.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1504 | 1346 | 116 |
| Full Text Views | 373 | 15 | 0 |
| PDF Downloads | 102 | 11 | 0 |