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1
Alves FP, Durlacher RR, Menezes MJ, Krieger H, Silva LH, Camargo EP, 2002. High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations. Am J Trop Med Hyg 66 :641–648.
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2
Kayentao K, Kodio M, Newman RD, Maiga H, Doumtabe D, Ongoiba A, Coulibaly D, Keita AS, Maiga B, Mungai M, Parise ME, Doumbo O, 2005. Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali. J Infect Dis 191 :109–116.
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3
Schellenberg D, Menendez C, Aponte JJ, Kahigwa E, Tanner M, Mshinda H, Alonso P, 2005. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365 :1481–1483.
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4
Marra F, Salzman JR, Ensom MH, 2003. Atovaquone-proguanil for prophylaxis and treatment of malaria. Ann Pharmacother 37 :1266–1275.
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5
Anonymous, 2004. Malarone. Physicians Desk Ref 58 :1567–1570.
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6
Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, Joubert I, Klein KC, Shaw D, Roskell NS, Chulay JD, Malarone International Study, 2000. Atovaquone/ proguanil versus chloroquine/proguanil for malaria prophylaxis in non-immune travellers: Results from a randomized, double blind study. Lancet 356 :1888–1894.
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7
Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, Toovey S, Knobloch J, Nothdurft HD, Shaw D, Roskell NS, Chulay JD, Malarone International Study Team, 2001. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study. Clin Infect Dis 33 :1015–1021.
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8
Camus D, Djossou F, Schilthuis HJ, Hogh B, Dutoit E, Malvy D, Roskell NS, Hedgley C, De Boever EH, Miller GB, International Malarone Study Team, 2004. Atovaquone-proguanil versus chloroquine-proguanil for malaria prphylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study. Clin Infect Dis 38 :1716–1723.
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9
Ling J, Baird JK, Fryauff DJ, Sismadi P, Bangs MJ, Lacy M, Barcus MJ, Gramzinski R, Maguire JD, Kumusumangsih M, Miller GB, Jones TR, Chulay JD, Hoffman SL, 2002. Naval Medical Research Unit 2 Clinical Trial Team. Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia. Clin Infect Dis 35 :825–833.
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10
Mendis K, Sina BJ, Marchesini P, Carter R, 2001. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64 (Suppl 12):97–106.
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11
Looareesuwan S, Wilairatana P, Glanarongran R, Indravijit KA, Supeeranontha L, Chinnapha S, Scott TR, Chulay JD, 1999. Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand. Trans R Soc Trop Med Hyg 93 :637–640.
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12
Soto J, Toledo J, Rodriquez M, Sanchez J, Herrera R, Padilla J, Berman J, 1998. Primaquine prophylaxis against malaria in non-immune Colombian soldiers: Efficacy and toxicity. Ann Intern Med 129 :241–244.
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13
Soto J, Toledo J, Rodriquez M, Sanchez J, Herrera R, Padilla J, Berman J, 1999. Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in non-immune Colombian soldiers. Clin Infect Dis 29 :199–201.
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RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY OF MALARONE FOR MALARIA PROPHYLAXIS IN NON-IMMUNE COLOMBIAN SOLDIERS
JAIME SOTO
JAIME SOTO
Consorcio de Investigaciones Bioclinicas, Bogota, Colombia; Fundacion Fader, Bogota, Colombia; AB Foundation for Medical Research, North Bethesda, Maryland; GlaxoSmithKline, Research & Development, Greenford, United Kingdom
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JULIA TOLEDO
JULIA TOLEDO
Consorcio de Investigaciones Bioclinicas, Bogota, Colombia; Fundacion Fader, Bogota, Colombia; AB Foundation for Medical Research, North Bethesda, Maryland; GlaxoSmithKline, Research & Development, Greenford, United Kingdom
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MAGDA LUZZ
MAGDA LUZZ
Consorcio de Investigaciones Bioclinicas, Bogota, Colombia; Fundacion Fader, Bogota, Colombia; AB Foundation for Medical Research, North Bethesda, Maryland; GlaxoSmithKline, Research & Development, Greenford, United Kingdom
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PATRICIA GUTIERREZ
PATRICIA GUTIERREZ
Consorcio de Investigaciones Bioclinicas, Bogota, Colombia; Fundacion Fader, Bogota, Colombia; AB Foundation for Medical Research, North Bethesda, Maryland; GlaxoSmithKline, Research & Development, Greenford, United Kingdom
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JONATHAN BERMAN
JONATHAN BERMAN
Consorcio de Investigaciones Bioclinicas, Bogota, Colombia; Fundacion Fader, Bogota, Colombia; AB Foundation for Medical Research, North Bethesda, Maryland; GlaxoSmithKline, Research & Development, Greenford, United Kingdom
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STEPHANE DUPARC
STEPHANE DUPARC
Consorcio de Investigaciones Bioclinicas, Bogota, Colombia; Fundacion Fader, Bogota, Colombia; AB Foundation for Medical Research, North Bethesda, Maryland; GlaxoSmithKline, Research & Development, Greenford, United Kingdom
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Malarone was compared with placebo in a double-blind, randomized, placebo-controlled trial of prophylaxis of malaria in predominately Plasmodium vivax areas of Colombia. The study population consisted of 180 completely non-immune Colombian soldiers, male, average age 19 years, and average weight 63 kg. Twenty-four subjects were considered unevaluable because of compliance issues, including one Malarone subject (with no detectable drug levels) who became infected with P. vivax. Of the 97 evaluable subjects who received Malarone (250 mg atovaquone plus 100 mg proguanil hydrochloride) daily from 1 day before entering the endemic area to 7 days after leaving the endemic area, none became parasitemic. Of the 46 evaluable placebo subjects, 11 became infected with P. vivax and 2 became infected with Plasmodium falciparum. The protective efficacy of Malarone for all malaria and for P. vivax malaria was 100% (LL 95% CI = 63%) and 100% (LL 95% CI = 58%), respectively, and was 96% if the one case with undetectable blood levels was included. Malarone has high protective efficacy for P. vivax in Colombia.
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RefWorks
Reference Manager
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-
1
Alves FP, Durlacher RR, Menezes MJ, Krieger H, Silva LH, Camargo EP, 2002. High prevalence of asymptomatic Plasmodium vivax and Plasmodium falciparum infections in native Amazonian populations. Am J Trop Med Hyg 66 :641–648.
-
2
Kayentao K, Kodio M, Newman RD, Maiga H, Doumtabe D, Ongoiba A, Coulibaly D, Keita AS, Maiga B, Mungai M, Parise ME, Doumbo O, 2005. Comparison of intermittent preventive treatment with chemoprophylaxis for the prevention of malaria during pregnancy in Mali. J Infect Dis 191 :109–116.
-
3
Schellenberg D, Menendez C, Aponte JJ, Kahigwa E, Tanner M, Mshinda H, Alonso P, 2005. Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial. Lancet 365 :1481–1483.
-
4
Marra F, Salzman JR, Ensom MH, 2003. Atovaquone-proguanil for prophylaxis and treatment of malaria. Ann Pharmacother 37 :1266–1275.
-
5
Anonymous, 2004. Malarone. Physicians Desk Ref 58 :1567–1570.
-
6
Hogh B, Clarke PD, Camus D, Nothdurft HD, Overbosch D, Gunther M, Joubert I, Klein KC, Shaw D, Roskell NS, Chulay JD, Malarone International Study, 2000. Atovaquone/ proguanil versus chloroquine/proguanil for malaria prophylaxis in non-immune travellers: Results from a randomized, double blind study. Lancet 356 :1888–1894.
-
7
Overbosch D, Schilthuis H, Bienzle U, Behrens RH, Kain KC, Clarke PD, Toovey S, Knobloch J, Nothdurft HD, Shaw D, Roskell NS, Chulay JD, Malarone International Study Team, 2001. Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study. Clin Infect Dis 33 :1015–1021.
-
8
Camus D, Djossou F, Schilthuis HJ, Hogh B, Dutoit E, Malvy D, Roskell NS, Hedgley C, De Boever EH, Miller GB, International Malarone Study Team, 2004. Atovaquone-proguanil versus chloroquine-proguanil for malaria prphylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study. Clin Infect Dis 38 :1716–1723.
-
9
Ling J, Baird JK, Fryauff DJ, Sismadi P, Bangs MJ, Lacy M, Barcus MJ, Gramzinski R, Maguire JD, Kumusumangsih M, Miller GB, Jones TR, Chulay JD, Hoffman SL, 2002. Naval Medical Research Unit 2 Clinical Trial Team. Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia. Clin Infect Dis 35 :825–833.
-
10
Mendis K, Sina BJ, Marchesini P, Carter R, 2001. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg 64 (Suppl 12):97–106.
-
11
Looareesuwan S, Wilairatana P, Glanarongran R, Indravijit KA, Supeeranontha L, Chinnapha S, Scott TR, Chulay JD, 1999. Atovaquone and proguanil hydrochloride followed by primaquine for treatment of Plasmodium vivax malaria in Thailand. Trans R Soc Trop Med Hyg 93 :637–640.
-
12
Soto J, Toledo J, Rodriquez M, Sanchez J, Herrera R, Padilla J, Berman J, 1998. Primaquine prophylaxis against malaria in non-immune Colombian soldiers: Efficacy and toxicity. Ann Intern Med 129 :241–244.
-
13
Soto J, Toledo J, Rodriquez M, Sanchez J, Herrera R, Padilla J, Berman J, 1999. Double-blind, randomized, placebo-controlled assessment of chloroquine/primaquine prophylaxis for malaria in non-immune Colombian soldiers. Clin Infect Dis 29 :199–201.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 673 | 573 | 215 |
| Full Text Views | 303 | 11 | 0 |
| PDF Downloads | 88 | 10 | 0 |