• 1

    Punyagupta S, Juttijudata P, Bunnag T, 1975. Eosinophilic meningitis in Thailand. Clinical studies of 484 typical cases probably caused by Angiostrongylus cantonensis. Am J Trop Med Hyg 24 :921–931.

    • Search Google Scholar
    • Export Citation
  • 2

    Chotmongkol V, Sawanyawisuth K, Thavornpitak Y, 2000. Corticosteroid treatment of eosinophilic meningitis. Clin Infect Dis 31 :660–662.

  • 3

    Cuckler AC, Egerton JR, Alicata JE, 1965. Therapeutic effects of thiabendazole on Angiostrongylus cantonensis infection in rats. J Parasitol 51 :392–396.

    • Search Google Scholar
    • Export Citation
  • 4

    Maki J, Yanagisawa T, 1986. Studies on antihelmintic effects of flubendazole and mebendazole on the rat lung worm Angiostrongylus cantonensis in mice and rats. J Parasitol 72 :512–516.

    • Search Google Scholar
    • Export Citation
  • 5

    Hwang KP, Chen ER, 1988. Larvicidal effects of albendazole against Angiostrongylus cantonensis in mice. Am J Trop Med Hyg 39 :191–195.

  • 6

    Kliks MM, Kroenke K, Hardman JM, 1982. Eosinophilic radiculomyeloencephalitis: an angiostrongyliasis outbreak in American Samoa related to ingestion of Achatina fulica snails. Am J Trop Med Hyg 31 :1114–1122.

    • Search Google Scholar
    • Export Citation
  • 7

    Hwang KP, Chen ER, 1991. Clinical studies on Angiostrongyliasis cantonensis among children in Taiwan. Southeast Asian J Trop Med Public Health 22 (Suppl):194–199.

    • Search Google Scholar
    • Export Citation
  • 8

    Chotmongkol V, Wongjitrat C, Sawadpanit K, Sawanyawisuth K, 2004. Treatment of eosinophilic meningitis with a combination of albendazole and corticosteroid. Southeast Asian J Trop Med Public Health 35 :172–174.

    • Search Google Scholar
    • Export Citation
  • 9

    Tsai HC, Liu YC, Kunin CM, Lee SS, Chen YS, Lin HH, Tsai TH, Lin WR, Huang CK, Yen MY, Yen CM, 2001. Eosinophilic meningitis caused by Angiostrongylus cantonensis: report of 17 cases. Am J Med 111 :109–114.

    • Search Google Scholar
    • Export Citation
  • 10

    Maleewong W, Sombatsawat P, Intapan PM, Wongkham C, Chotmongkol V, 2001. Immunoblot evaluation of the specific of the 29 kDa antigen from young adult female worms Angiostrongylus cantonensis for immunodiagnosis of human angiostrongyliasis. Asian Pac J Allergy Immunol 19 :267–273.

    • Search Google Scholar
    • Export Citation
 
 
 

 

 

 

 

 

 

TREATMENT OF EOSINOPHILIC MENINGITIS WITH A COMBINATION OF PREDNISOLONE AND MEBENDAZOLE

View More View Less
  • 1 Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

To study the efficacy of the combination of prednisolone and mebendazole for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis. Patients were given a two-week course of prednisolone, 60 mg/day, and mebendazole, 10 mg/kg/day. The primary observation parameter was the number of patients who still had headaches after the two-week course of treatment. Forty-one patients were enrolled in the study. Four (10%) patients still had headaches after the two-week course of treatment and the median length of time until complete disappearance of headaches was three days. Serious side effects were not detected. Treatment for two weeks with the combination regimen of prednisolone and mebendazole is safe and beneficial in relieving headaches in patients with eosinophilic meningitis.

Save