Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Murray CJL, López AD, 1997. Mortality by cause for eight regions of the world: Global burden of disease study. Lancet 349 :1969–1976.
-
2
Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, 1995. Manual of Clinical Microbiology. Washington, DC: ASM Press.
-
3
Cabrera R, Ruiz J, Marco F, Oliveira I, Arroyo M, Aladueña A, Usera MA, Jiménez de Anta MT, Gascón J, Vila J, 2004. Characterization of the mechanism of resistance to several antimicrobial agents in Salmonella clinical isolates causing traveler’s diarrhea. Antimicrob Agents Chemother 48 :3934–3939.
-
4
Stock I, Wiedemann B, 2000. Natural antibiotic susceptibility of Salmonella enterica strains. Int J Antimicrob Agents 16 :211– 217.
-
5
Cabrera R, Ramírez M, Bravo L, García B, Fernández A, 1998. Serotipaje de los microorganismos pertenecientes al género Salmonella. Enf Infec Microbiol 18 :150–152.
-
6
Estevez Touzard M, Díaz González M, Monte Boada RJ, Toledo Rodríguez I, Ramón Bravo J, 1993. The infectious etiology of acute diarrheal diseases in the Republic of Cuba, 1991. Rev Cub Med Trop 45 :139–145.
-
7
Llop A, 2002. Antimicrobial resistance and microbiological surveillance in Cuba. In: Salvatierra-Gonzalez R, Benguigui Y, eds. Antimicrobial Resistance in the Americas: Magnitude and Containment of the Problem. Washington, DC: Pan American Health Organization; 111–118.
-
8
Sabaté M, Prats G, 2002. Estructura y función de los integrones. Enferm Infecc Microbiol Clin 20 :341–345
-
9
Guerra B, Soto S, Cal S, Mendoza MC, 2000. Antimicrobial resistance and spread of Class 1 integrons among Salmonella serotypes. Antimicrob Agents Chemother 44 :2166–2169.
-
10
Roe MT, Vega E, Pillai SD, 2003. Antimicrobial resistance markers of Class 1 and Class 2 integron-bearing Escherichia coli from irrigation water and sediments. Emerg Infect Dis 9 :822–826.
-
11
Severino P, Magalhaes VD, 2004. Integrons as tools for epidemiological studies. Clin Microbiol Infect 10 :156–162.
-
12
Boop CA, Brenner FW, Wells JG, Strockbine NA, 1999. Escherichia, Shigella and Salmonella. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, eds. Manual of Clinical Microbiology. 7th ed. Washington, DC: ASM Press; 459–474.
-
13
National Committee for Clinical Laboratory Standards, 2003. Performance Standards for Antimicrobial Susceptibility Testing. 9th ed. Wayne, PA: National Committee for Clinical Laboratory Standards.
-
14
Guerra B, Malorny B, Schroeter A, Helmuth R, 2003. Multiple resistance mechanisms in fluoroquinolone-resistant Salmonella isolates from Germany. Antimicrob Agents Chemother 47 :2059.
-
15
Navia MM, Ruiz J, Sánchez Céspedes J, Vila J, 2003. Detection of dihydrofolate reductase genes by PCR and RFLP. Diagn Microbiol Infect Dis 46 :295–298.
-
16
Gautom RK, 1997. Rapid pulsed-field gel electrophoresis protocol for typing of Escherichia coli O157:H7 and other Gram-negative organisms in 1 day. J Clin Microbiol 35 :2977–2980.
-
17
Lawson AJ, Desai M, O’Brien SJ, Davies RH, Ward LR, Therfall EJ, 2004. Molecular characterization of an outbreak strain of multiresistant Salmonella enterica serovar Typhimurium DT104 in the UK. Clin Microbiol Infect 10 :143–147.
-
18
Threlfall EJ, 2000. Epidemic Salmonella typhimurium DT 104-a truly international multirresistant clone. J Antimicrob Chemother 46 :7–10.
-
19
Baggesen DL, Sandvang D, Aarestrup FM, 2000. Characterization of Salmonella enterica serovar Typhimurium DT104 isolated from Denmark and comparison with isolates from Europe and the United States. J Clin Microbiol 38 :1581–1586.
-
20
Martin LJ, Fyfe M, Dore K, Buxton JA, Pollari F, Henry B, Middleton D, Ahmed R, Jamieson F, Ciebin B, McEwen SA, Wilson JB, 2004. Increased burden of illness associated with antimicrobial-resistant Salmonella enterica serotype Typhimurium infections. J Infect Dis 189 :377–384.
-
21
Meunier D, Boyd D, Mulvey MR, Baucheron S, Mammina C, Nastasi A, Chaslus-Dancla E, Cloeckaert A, 2002. Salmonella enterica serotype Typhimurium DT104 antibiotic resistance genomic island I in serotype paratyphi B. Emerg Infect Dis 8 :430–433.
-
22
Espinase F, Gheorghiu R, Poiata A, Labia R, Nicolas-Chanoine MH, 1997. Reduced susceptibility to co-amoxiclav in Escherichia coli, Salmonella Typhimurium and Klebsiella pneumoniae isolated in Romania between 1985 and 1993. J Antimicrob Chemother 39 :103–106.
-
23
Ruiz J, Navia MM, Marco F, Vila J, 2004. Mecanismos de resistencia a betalactámicos y ácido nalidíxico en aislados clínicos de Salmonella enterica serotipo Hadar y Bsilla. Enferm Infecc Microbiol Clin 22 :252–253.
-
24
Valdezate S, Echeíta A, Díez R, Usera MA, 2000 Evaluation of phenotypic and genotypic markers for characterization of the emerging gastroenteritis pathogen Salmonella Hadar. Eur J Clin Microbiol Infect Dis 19: 275–281.
-
25
Reguera JA, Baquero F, Pérez-Díaz JC, Martínez JL, 1991. Factors determining resistance to β-lactam combined with β-lactamase inhibitors in Escherichia coli. J Antimicrob Chemother 27 :569–573.
-
26
Carattoli A, Filetici E, Villa L, Dionisi AM, Ricci A, Luzzi I, 2002. Antibiotic resistance genes and Salmonella genomic island 1 in Salmonella enterica serovar Typhimurium isolated in Italy. Antimicrob Agents Chemother 46 :2821–2828.
-
27
Poirel L, Guibert M, Bellais S, Naas T, Nordmann P, 1999. Integron-and Carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype Typhimurium DT 104 from French patients. Antimicrob Agents Chemother 43 :1098–1104.
-
28
Doublet B, Lailler R, Meunier D, Brisabois A, Boyd D, Mulvey MR, Chaslus-Dancla E, Cloeckaert A, 2003. Variant Salmonella genomic island 1 resistance gene cluster in Salmonella enterica serovar Albany. Emerg Infect Dis 5 :585–591.
-
29
Tavechio AT, Ghilardi AC, Peresi JT, Fuzihara TO, Yonamine EKM, Fernández SA, 2002. Salmonella serotypes isolated from nonhuman sources in Salmonella in Brazil, from 1996 through 2000. J Food Prot 65 :1041–1044.
-
30
Cruchaga S, Echeíta A, Aladueña A, García-Peña J, Frias N, Usera MA, 2001. Antimicrobial resistance in Salmonella from humans, food and animals in Spain in 1998. J Antimicrob Chemother 47 :315–321.
-
31
Centers for Disease Control, 1998. Multistate outbreak of Salmonella serotype Agona infections linked to toasted oats cereal-United States. JAMA 280 :411.
-
32
Eiguer T, Butta N, 1983. Annual distribution of serotypes of Salmonella, Shigella, and infantile enteropathogenic Escherichia coli in the Republic of Argentina 1979–1981. Rev Argent Microbiol 15 :19–24.
-
33
Gutiérrez-Cogco L, Montiel-Vázquez E, Aguilera-Pérez P, González-Andrade MC, 2000. Serotipos de Salmonella identificados en los servicios de salud de México. Salud Pública Méx 42 :490–495.
-
34
Boyd D, Cloeckaert A, Chaslus-Dancla E, Mulvey MR, 2002. Characterization of variant Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona. Antimicrob Agents Chemother 46 :1714–1722.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 662 | 545 | 12 |
| Full Text Views | 287 | 14 | 0 |
| PDF Downloads | 75 | 10 | 0 |
DISSEMINATION OF SALMONELLA ENTERICA SEROTYPE AGONA AND MULTIDRUG-RESISTANT SALMONELLA ENTERICA SEROTYPE TYPHIMURIUM IN CUBA
ROBERTO CABRERA
ROBERTO CABRERA
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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JOAQUIM RUIZ
JOAQUIM RUIZ
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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MARGARITA RAMÍREZ
MARGARITA RAMÍREZ
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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LAURA BRAVO
LAURA BRAVO
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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ANABEL FERNÁNDEZ
ANABEL FERNÁNDEZ
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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ANA ALADUEÑA
ANA ALADUEÑA
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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AURORA ECHEÍTA
AURORA ECHEÍTA
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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JOAQUIM GASCÓN
JOAQUIM GASCÓN
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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PEDRO L. ALONSO
PEDRO L. ALONSO
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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JORDI VILA
JORDI VILA
Servicio de Microbiología, IDIBAPS, Hospital Clínic, Barcelona, Spain; Centro de Salud Internacional, Universidad de Barcelona, Hospital Clínic, Barcelona, Spain; Instituto de Medicina Tropical “Pedro Kourí,” Ciudad Habana, Cuba; Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
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The molecular epidemiology, antimicrobial susceptibility, and mechanisms of resistance of 34 Salmonella spp. strains causing acute gastroenteritis, isolated from different provinces in Cuba, were determined. Sixty-four percent of the strains showed multiresistance. Salmonella typhimurium was the most frequent with 15 strains (44%), 13 of which belonged to phagotype 104 and presented similar genetic profiles of pulsed field gel electrophoresis. High levels of resistance to tetracycline (53%), spectinomycin (50%), ampicillin (44%), and chloramphenicol (41%) were found. Resistance to tetracycline was associated with the tet G and tet A genes. Resistance to ampicillin was caused by the presence of β-lactamases, mainly the CARB type. The floR gene was the main mechanism of resistance to chloramphenicol. Our results showed an antimicrobial susceptible clone of Salmonella enterica serotype Agona in two separate regions. This is the first report of the widespread dissemination of a multiresistant clone of S. enterica serotype Typhimurium definitive phage type 104 in Cuba.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Murray CJL, López AD, 1997. Mortality by cause for eight regions of the world: Global burden of disease study. Lancet 349 :1969–1976.
-
2
Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, 1995. Manual of Clinical Microbiology. Washington, DC: ASM Press.
-
3
Cabrera R, Ruiz J, Marco F, Oliveira I, Arroyo M, Aladueña A, Usera MA, Jiménez de Anta MT, Gascón J, Vila J, 2004. Characterization of the mechanism of resistance to several antimicrobial agents in Salmonella clinical isolates causing traveler’s diarrhea. Antimicrob Agents Chemother 48 :3934–3939.
-
4
Stock I, Wiedemann B, 2000. Natural antibiotic susceptibility of Salmonella enterica strains. Int J Antimicrob Agents 16 :211– 217.
-
5
Cabrera R, Ramírez M, Bravo L, García B, Fernández A, 1998. Serotipaje de los microorganismos pertenecientes al género Salmonella. Enf Infec Microbiol 18 :150–152.
-
6
Estevez Touzard M, Díaz González M, Monte Boada RJ, Toledo Rodríguez I, Ramón Bravo J, 1993. The infectious etiology of acute diarrheal diseases in the Republic of Cuba, 1991. Rev Cub Med Trop 45 :139–145.
-
7
Llop A, 2002. Antimicrobial resistance and microbiological surveillance in Cuba. In: Salvatierra-Gonzalez R, Benguigui Y, eds. Antimicrobial Resistance in the Americas: Magnitude and Containment of the Problem. Washington, DC: Pan American Health Organization; 111–118.
-
8
Sabaté M, Prats G, 2002. Estructura y función de los integrones. Enferm Infecc Microbiol Clin 20 :341–345
-
9
Guerra B, Soto S, Cal S, Mendoza MC, 2000. Antimicrobial resistance and spread of Class 1 integrons among Salmonella serotypes. Antimicrob Agents Chemother 44 :2166–2169.
-
10
Roe MT, Vega E, Pillai SD, 2003. Antimicrobial resistance markers of Class 1 and Class 2 integron-bearing Escherichia coli from irrigation water and sediments. Emerg Infect Dis 9 :822–826.
-
11
Severino P, Magalhaes VD, 2004. Integrons as tools for epidemiological studies. Clin Microbiol Infect 10 :156–162.
-
12
Boop CA, Brenner FW, Wells JG, Strockbine NA, 1999. Escherichia, Shigella and Salmonella. In: Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, eds. Manual of Clinical Microbiology. 7th ed. Washington, DC: ASM Press; 459–474.
-
13
National Committee for Clinical Laboratory Standards, 2003. Performance Standards for Antimicrobial Susceptibility Testing. 9th ed. Wayne, PA: National Committee for Clinical Laboratory Standards.
-
14
Guerra B, Malorny B, Schroeter A, Helmuth R, 2003. Multiple resistance mechanisms in fluoroquinolone-resistant Salmonella isolates from Germany. Antimicrob Agents Chemother 47 :2059.
-
15
Navia MM, Ruiz J, Sánchez Céspedes J, Vila J, 2003. Detection of dihydrofolate reductase genes by PCR and RFLP. Diagn Microbiol Infect Dis 46 :295–298.
-
16
Gautom RK, 1997. Rapid pulsed-field gel electrophoresis protocol for typing of Escherichia coli O157:H7 and other Gram-negative organisms in 1 day. J Clin Microbiol 35 :2977–2980.
-
17
Lawson AJ, Desai M, O’Brien SJ, Davies RH, Ward LR, Therfall EJ, 2004. Molecular characterization of an outbreak strain of multiresistant Salmonella enterica serovar Typhimurium DT104 in the UK. Clin Microbiol Infect 10 :143–147.
-
18
Threlfall EJ, 2000. Epidemic Salmonella typhimurium DT 104-a truly international multirresistant clone. J Antimicrob Chemother 46 :7–10.
-
19
Baggesen DL, Sandvang D, Aarestrup FM, 2000. Characterization of Salmonella enterica serovar Typhimurium DT104 isolated from Denmark and comparison with isolates from Europe and the United States. J Clin Microbiol 38 :1581–1586.
-
20
Martin LJ, Fyfe M, Dore K, Buxton JA, Pollari F, Henry B, Middleton D, Ahmed R, Jamieson F, Ciebin B, McEwen SA, Wilson JB, 2004. Increased burden of illness associated with antimicrobial-resistant Salmonella enterica serotype Typhimurium infections. J Infect Dis 189 :377–384.
-
21
Meunier D, Boyd D, Mulvey MR, Baucheron S, Mammina C, Nastasi A, Chaslus-Dancla E, Cloeckaert A, 2002. Salmonella enterica serotype Typhimurium DT104 antibiotic resistance genomic island I in serotype paratyphi B. Emerg Infect Dis 8 :430–433.
-
22
Espinase F, Gheorghiu R, Poiata A, Labia R, Nicolas-Chanoine MH, 1997. Reduced susceptibility to co-amoxiclav in Escherichia coli, Salmonella Typhimurium and Klebsiella pneumoniae isolated in Romania between 1985 and 1993. J Antimicrob Chemother 39 :103–106.
-
23
Ruiz J, Navia MM, Marco F, Vila J, 2004. Mecanismos de resistencia a betalactámicos y ácido nalidíxico en aislados clínicos de Salmonella enterica serotipo Hadar y Bsilla. Enferm Infecc Microbiol Clin 22 :252–253.
-
24
Valdezate S, Echeíta A, Díez R, Usera MA, 2000 Evaluation of phenotypic and genotypic markers for characterization of the emerging gastroenteritis pathogen Salmonella Hadar. Eur J Clin Microbiol Infect Dis 19: 275–281.
-
25
Reguera JA, Baquero F, Pérez-Díaz JC, Martínez JL, 1991. Factors determining resistance to β-lactam combined with β-lactamase inhibitors in Escherichia coli. J Antimicrob Chemother 27 :569–573.
-
26
Carattoli A, Filetici E, Villa L, Dionisi AM, Ricci A, Luzzi I, 2002. Antibiotic resistance genes and Salmonella genomic island 1 in Salmonella enterica serovar Typhimurium isolated in Italy. Antimicrob Agents Chemother 46 :2821–2828.
-
27
Poirel L, Guibert M, Bellais S, Naas T, Nordmann P, 1999. Integron-and Carbenicillinase-mediated reduced susceptibility to amoxicillin-clavulanic acid in isolates of multidrug-resistant Salmonella enterica serotype Typhimurium DT 104 from French patients. Antimicrob Agents Chemother 43 :1098–1104.
-
28
Doublet B, Lailler R, Meunier D, Brisabois A, Boyd D, Mulvey MR, Chaslus-Dancla E, Cloeckaert A, 2003. Variant Salmonella genomic island 1 resistance gene cluster in Salmonella enterica serovar Albany. Emerg Infect Dis 5 :585–591.
-
29
Tavechio AT, Ghilardi AC, Peresi JT, Fuzihara TO, Yonamine EKM, Fernández SA, 2002. Salmonella serotypes isolated from nonhuman sources in Salmonella in Brazil, from 1996 through 2000. J Food Prot 65 :1041–1044.
-
30
Cruchaga S, Echeíta A, Aladueña A, García-Peña J, Frias N, Usera MA, 2001. Antimicrobial resistance in Salmonella from humans, food and animals in Spain in 1998. J Antimicrob Chemother 47 :315–321.
-
31
Centers for Disease Control, 1998. Multistate outbreak of Salmonella serotype Agona infections linked to toasted oats cereal-United States. JAMA 280 :411.
-
32
Eiguer T, Butta N, 1983. Annual distribution of serotypes of Salmonella, Shigella, and infantile enteropathogenic Escherichia coli in the Republic of Argentina 1979–1981. Rev Argent Microbiol 15 :19–24.
-
33
Gutiérrez-Cogco L, Montiel-Vázquez E, Aguilera-Pérez P, González-Andrade MC, 2000. Serotipos de Salmonella identificados en los servicios de salud de México. Salud Pública Méx 42 :490–495.
-
34
Boyd D, Cloeckaert A, Chaslus-Dancla E, Mulvey MR, 2002. Characterization of variant Salmonella genomic island 1 multidrug resistance regions from serovars Typhimurium DT104 and Agona. Antimicrob Agents Chemother 46 :1714–1722.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 662 | 545 | 12 |
| Full Text Views | 287 | 14 | 0 |
| PDF Downloads | 75 | 10 | 0 |