MALARIA LIVER STAGE CULTURE: IN VITRO VERITAS?

STEFAN H. I. KAPPE Seattle Biomedical Research Institute, Seattle, Washington

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PATRICK E. DUFFY Seattle Biomedical Research Institute, Seattle, Washington

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Author Notes

  • 1

    Shortt HE, Garnham PCC, 1948. Pre-erythrocytic stage in mammalian malaria parasites. Nature 161 :126.

  • 2

    Shortt HE, Fairley NH, Covell G, Shute PG, Garnham PC, 1951. The pre-erythrocytic stage of Plasmodium falciparum. Trans R Soc Trop Med Hyg 44 :405–419.

  • 3

    Schaudinn F, 1903. Studien ueber krankheitserregende Protozoen II. Plasmodium vivax (Grassi und Feletti), der Erreger des Tertianfiebers beim Menschen. Arb Kaiserl Gesundheits 19 :169–250.

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  • 4

    Shortt HE, Garnham PCC, 1948. The pre-erythrocytic development of Plasmodium cynomolgi and Plasmodium vivax. Trans R Soc Trop Med Hyg 41 :785–795.

  • 5

    Frevert U, 2004. Sneaking in through the back entrance: the biology of malaria liver stages. Trends Parasitol 20 :417–424.

  • 6

    Crispe IN, 2003. Hepatic T cells and liver tolerance. Nat Rev Immunol 3 :51–62.

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    Winzeler EA, 2006. Applied systems biology and malaria. Nat Rev Microbiol 4 :145–151.

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    Luke TC, Hoffman SL, 2003. Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine. J Exp Biol 206 :3803–3808.

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  • 9

    Hollingdale MR, Leland P, Schwartz AL, 1983. In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in a hepatoma cell line. Am J Trop Med Hyg 32 :682–684.

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  • 10

    Karnasuta C, Pavanand K, Chantakulkij S, Luttiwongsakorn N, Rassamesoraj M, Laohathai K, Webster HK, Watt G, 1995. Complete development of the liver stage of Plasmodium falciparum in a human hepatoma cell line. Am J Trop Med Hyg 53 :607–611.

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  • 11

    Mazier D, Beaudoin RL, Mellouk S, Druilhe P, Texier B, Trosper J, Miltgen F, Landau I, Paul C, Brandicourt O, 1985. Complete development of hepatic stages of Plasmodium falciparum in vitro. Science 227 :440–442.

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  • 12

    Sattabongkot J, Yimamnuaychoke N, Leelaudomlipi S, Rasameesoraj M, Jenwithisuk R, Coleman RE, Udomsangpetch R, Cui L, Brewer TG, 2006. Establishment of a human hepatocyte line that supports in vitro development of the exoerythrocytic stages of the malaria parasites Plasmodium falciparum and P. vivax. Am J Trop Med Hyg 74 :708–715.

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