• 1

    Gubler DJ, 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11 :480–496.

  • 2

    World Health Organization, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization.

  • 3

    World Health Organization (WHO), 2002. Dengue and dengue hemorrhagic fever. Fact sheet No.117. Geneva: WHO.

  • 4

    Halstead SB, Lan NT, Myint TT, Shwe TN, Nisalak A, Kalyanarooj S, Nimmannitya S, Soegijanto S, Vaughn DW, Endy TP, 2002. Dengue hemorrhagic fever in infants: research opportunities ignored. Emerg Infect Dis 8 :1474–1479.

    • Search Google Scholar
    • Export Citation
  • 5

    Hung NT, Lei HY, Lan NT, Lin YS, Huang KJ, Lien LB, Lin CF, Yeh TM, Ha DQ, Huong VTQ, Chen LC, Huang JH, My LT, Liu CC, Halstead SB, 2004. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis 189 :221–232.

    • Search Google Scholar
    • Export Citation
  • 6

    Nimmannitya S, 1997. Dengue hemorrhagic fever: diagnosis and management. Gubler DJ, Kuno G, eds. Dengue and Dengue Hemorrhagic Fever. Wallingford, United Kingdom: CAB International, 133–146.

  • 7

    Ngo NT, Cao XT, Kneen R, Wills B, Nguyen VM, Nguyen TQ, Chu VT, Nguyen TT, Simpson JA, Solomon T, White NJ, Farrar J, 2001. Acute management of dengue shock syndrome: a randomized double-blind comparison of 4 intravenous fluid regimens in the first hour. Clin Infect Dis 32 :204–213.

    • Search Google Scholar
    • Export Citation
  • 8

    Lan NT, Hung NT, Ha DQ, Phuong BT, Lien LB, Tuan LA, Huong VT, Hieu LTM, Tran TN, Cam LT, Tuan NA, 1998. Treatment of dengue haemorrhagic fever at Children’s Hospital No. 1, Ho Chi Minh City, 1991–1996. Dengue Bull 22 :150–161.

    • Search Google Scholar
    • Export Citation
  • 9

    Hung NT, Lan NT, 2003. Improvement of case management: a key factor to reduce case-fatality rate of dengue hemorrhagic fever in southern Vietnam. Dengue Bull 22 :144–148.

    • Search Google Scholar
    • Export Citation
  • 10

    Hadinegoro SR, Purwanto SH, Chatab F, 1999. Dengue shock syndrome: clinical manifestations, management and outcome—A hospital-based study in Jakarta, Indonesia. Dengue Bull 23 :105–106.

    • Search Google Scholar
    • Export Citation
  • 11

    Hongsiriwon S, 2002. Dengue hemorrhagic fever in infants. Southeast Asian J Trop Med Public Health 33 :49–55.

  • 12

    Hung NT, Lan NT, Lei HY, Lin YS, Lien LB, Huang KJ, Lin CF, Ha DQ, Huong VTQ, My LT, Yeh TM, Huang JH, Liu CC, Halstead SB, 2005. Association between sex, nutritional status, severity of dengue hemorrhagic fever, and immune status in infants with dengue hemorrhagic fever. Am J Trop Med Hyg 72 :370–374.

    • Search Google Scholar
    • Export Citation
  • 13

    Shu PY, Chen LK, Chang SF, Yueh YY, Chow L, Chien LJ, Chin C, Yang HH, Lin TH, Huang JH, 2003. Comparison of capture immunoglobulin M (IgM) and IgG enzyme-linked immunosorbent assay (ELISA) and nonstructural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections. Clin Diagn Lab Immunol 10 :622–630.

    • Search Google Scholar
    • Export Citation
  • 14

    Kuno G, Gomez I, Gubler DJ, 1987. Detecting artificial anti-dengue IgM immune complexes using an enzyme-linked immunosorbent assay. Am J Trop Med Hyg 36 :153–159.

    • Search Google Scholar
    • Export Citation
  • 15

    Kliks SC, Nimmannitya S, Nisalak A, Burke DS, 1988. Evidence that maternal antibodies are important in the development of dengue hemorrhagic fever in infants. Am J Trop Med Hyg 38 :411–419.

    • Search Google Scholar
    • Export Citation
  • 16

    Lei HY, Yeh TM, Liu HS, Lin YS, Chen SH, Liu CC, 2001. Immunopathogenesis of dengue virus infection. J Biomed Sci 8 :377–388.

  • 17

    Hung NT, Lan NT, 2001. Treatment of dengue hemorrhagic fever at Children’s Hospital No. 1, Ho Chi Minh City, 1991–2000. Med J Ho Chi Minh City 3 :149–152.

    • Search Google Scholar
    • Export Citation
  • 18

    Nimmannitya S, 1987. Clinical spectrum and management of dengue hemorrhagic fever. Southeast Asian J Trop Med Public Health 18 :392–397.

    • Search Google Scholar
    • Export Citation
  • 19

    Lum LCS, Thong MK, Cheak YK, Lam SK, 1995. Dengue associated with adult respiratory distress syndrome. Ann Trop Pediatr 15 :335–339.

  • 20

    Cam BV, Tuan DT, Tuan HM, Tien NM, Fonsmark L, Poulsen A, 2002. Randomized comparison of oxygen mask treatment vs. nasal continuous positive airway pressure in Dengue shock syndrome with acute respiratory failure. J Trop Pediatr 48 :335–339.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 141 128 15
PDF Downloads 37 33 1
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

VOLUME REPLACEMENT IN INFANTS WITH DENGUE HEMORRHAGIC FEVER/DENGUE SHOCK SYNDROME

NGUYEN THANH HUNGDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by NGUYEN THANH HUNG in
Current site
Google Scholar
PubMed
Close
,
NGUYEN TRONG LANDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by NGUYEN TRONG LAN in
Current site
Google Scholar
PubMed
Close
,
HUAN-YAO LEIDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by HUAN-YAO LEI in
Current site
Google Scholar
PubMed
Close
,
YEE-SHIN LINDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by YEE-SHIN LIN in
Current site
Google Scholar
PubMed
Close
,
LE BICH LIENDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by LE BICH LIEN in
Current site
Google Scholar
PubMed
Close
,
KAO-JEAN HUANGDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by KAO-JEAN HUANG in
Current site
Google Scholar
PubMed
Close
,
CHIOU-FENG LINDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by CHIOU-FENG LIN in
Current site
Google Scholar
PubMed
Close
,
DO QUANG HADepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by DO QUANG HA in
Current site
Google Scholar
PubMed
Close
,
VU THI QUE HUONGDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by VU THI QUE HUONG in
Current site
Google Scholar
PubMed
Close
,
LAM THI MYDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by LAM THI MY in
Current site
Google Scholar
PubMed
Close
,
TRAI-MING YEHDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by TRAI-MING YEH in
Current site
Google Scholar
PubMed
Close
,
JYH-HSIUNG HUANGDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by JYH-HSIUNG HUANG in
Current site
Google Scholar
PubMed
Close
,
CHING-CHUAN LIUDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by CHING-CHUAN LIU in
Current site
Google Scholar
PubMed
Close
, and
SCOTT B. HALSTEADDepartment of Dengue Hemorrhagic Fever, Children’s Hospital No. 1, Ho Chi Minh City, Vietnam; Department of Microbiology and Immunology, Department of Medical Technology, and Department of Pediatrics, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China; Arbovirus Laboratory, Pasteur Institute, Ho Chi Minh City, Vietnam; Department of Pediatrics, University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam; Division of Research and Diagnosis, Department of Health, Center for Disease Control, Taipei, Taiwan, Republic of China; Uniformed Services University of the Health Sciences, Bethesda, Maryland

Search for other papers by SCOTT B. HALSTEAD in
Current site
Google Scholar
PubMed
Close
Restricted access

Volume replacement was studied prospectively in 208 infants with dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). The mean volume of intravenous fluid used was 110.4 mL/kg administered over a mean period of 25.8 hours. The mean volumes of intravenous fluid replacement in infants with DSS was significantly higher than in those with non-shock DHF (129.8 mL/kg versus 102.1 mL/kg; P = 0.001). Patients with DSS had significantly higher proportional requirements for dextran and blood transfusions than non-shock infants. Recurrent shock, prolonged shock, and acute respiratory failure were recorded in 8, 6, and 13 patients, respectively. Four patients with DSS died of severe complications. Intravenous fluid replacement with special care to avoid fluid overload requires careful attention to established indications for use of colloidal solutions and blood transfusions. To improve case fatality rates, special efforts need to be directed to infants with DHF/DSS accompanied by severe complications.

Save