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FAILURE OF STANDARD TREATMENT WITH PRAZIQUANTEL IN TWO RETURNED TRAVELERS WITH SCHISTOSOMA HAEMATOBIUM INFECTION

DAVID ALONSOInternational Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain

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JOSE MUÑOZInternational Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain

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JOAQUIM GASCÓNInternational Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain

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MARIA EUGENIA VALLSInternational Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain

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MANUEL CORACHANInternational Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain

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A single 40 mg/kg dose of praziquantel (PZQ) continues to be the standard treatment for schistosomiasis caused by S. mansoni and S. haematobium in all clinical settings. Experimental development of drug resistance and the recent isolation of S. mansoni strains with a natural tolerance to high doses of PZQ have raised concerns over the adequacy of such a dose. We describe two Spanish travelers with genitourinary schistosomiasis caused by S. haematobium in whom repeated standard treatment failed to clear the infection.

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