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IMPAIRMENT OF HOST IMMUNE RESPONSE AGAINST STRONGYLOIDES STERCORALIS BY HUMAN T CELL LYMPHOTROPIC VIRUS TYPE 1 INFECTION

TETSUO HIRATAControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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NOBUFUMI UCHIMAControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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KAZUTO KISHIMOTOControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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OSAMU ZAHAControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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NAGISA KINJOControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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AKIRA HOKAMAControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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HIROSHI SAKUGAWAControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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FUKUNORI KINJOControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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JIRO FUJITAControl and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan; Department of Endoscopy and Department of Blood Transfusion Medicine, Ryukyu University Hospital, Okinawa, Japan; Department of Internal Medicine, Nakagami Hospital, Okinawa, Japan

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A large-scale study was undertaken to clarify the prevalence rate of strongyloidiasis in Okinawa, Japan and to evaluate the relationship between strongyloidiasis and infection with human T cell lymphotropic virus type 1 (HTLV-1). The prevalence rate of Strongyloides stercoralis and HTLV-1 infection were 6.3% and 14.0%, respectively. Among 2,185 patients more than 50 years of age, the rate of S. stercoralis infection was significantly higher in patients with HTLV-1 infection compared with patients without HTLV-1 infection. In 252 patients treated with ivermectin, serum IgE levels and peripheral eosinophil counts were significantly lower in HTLV-1 co-infected patients compared with patients without HTLV-1 infection. In addition, the anthelmintic effect was significantly lower in patients with HTLV-1 infection compared with patients without HTLV-1 infection. Our prospective study demonstrated a prevalence rate for strongyloidiasis and HTLV-1 infections, and clearly demonstrated that co-infection with HTLV-1 impaired the immune response against S. stercoralis.

Author Notes

Reprint requests: Tetsuo Hirata, Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan, E-mail: h400314@med.u-ryukyu.ac.jp
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