• 1

    Dodig M, Tavill A, 2001. Hepatitis C and human immunodeficiency virus coinfection. J Clin Gastroenterol 33 :367–374.

  • 2

    Darby SC, Ewart DW, Giangrande PL, Spooner RJ, Rizza CR, Dusheiko GM, Lee CA, Ludman CN, Preston FE, 1997. Mortality from liver cancer and liver disease in haemophilic men and boys in UK given blood product contaminated with hepatitis C. UK Hemophilia Center directors’ organization. Lancet 350 :1425–1431.

    • Search Google Scholar
    • Export Citation
  • 3

    Appel PW, Joseph H, Richman BL, 2000. Causes and rate of death among methadone maintenance patients before and after the onset of the HIV/AIDS epidemic. Mt Sinai J Med 67 :4444–4451.

    • Search Google Scholar
    • Export Citation
  • 4

    Dragoni F, Cafolla A, Gentile G, Mazzucconi MG, Vella S, di Corpo U, Tosti ME, Pisani G, Donato V, Martino P, 1999. HIV-HCV RNA load and liver failure in coinfected patients with coagulopathy. Haematologica 84 :525–529.

    • Search Google Scholar
    • Export Citation
  • 5

    Soto B, Sanchez-Quijano A, Rodrigo L, del Olmo JA, Garcia-Bengoechea M, Hernandez-Quero J, Rey C, Abad MA, Rodriguez M, Sales Gilabert M, Gonzalez F, Miron P, Caruz A, Relimpio F, Torronteras R, Leal M, Lissen E, 1997. Human immunodeficiency virus infection modifies the natural history of chronic parenterally-acquired hepatitis C with an unusually rapid progression to cirrhosis. J Hepatol 26 :1–5.

    • Search Google Scholar
    • Export Citation
  • 6

    Garcia-Samaniego J, Soriano V, Castilla J, Bravo R, Moreno A, Carbo J, Iniguez A, Gonzalez J, Munoz F, 1997. Influence of hepatitis C virus genotype and HIV infection on histological severity of chronic hepatitis C. The hepatitis/HIV Spanish group. Am J Gastroenterol 92 :1130–1134.

    • Search Google Scholar
    • Export Citation
  • 7

    Bica I, McGovern B, Dhar R, Stone D, McGowan K, Scheib R, Snydman DR, 2001. Increasing mortality due to end-stage liver disease in patients with human immunodeficiency virus infection. Clin Infect Dis 32 :492–497.

    • Search Google Scholar
    • Export Citation
  • 8

    Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, Laeyendecker O, Boitnott J, Wilson LE, Vlahov D, 2000. The natural history of hepatitis c virus infection: host, virus and environmental factors. JAMA 284 :450–456.

    • Search Google Scholar
    • Export Citation
  • 9

    Center for Disease Control, 2001. Prevalence of hepatitis C virus infection among clients of HIV counseling and testing sites, Connecticut 1999. MMWR Morb Mortal Wkly Rep 50 :577–581.

    • Search Google Scholar
    • Export Citation
  • 10

    Dieterich DT, 1999. Hepatitis C virus and human immunodeficiency virus: Clinical issues in coinfection. Am J Med 107 :79S–84S.

  • 11

    MacDonald M, Crofts N, Kaldor J, 1996. Transmission of hepatitis C virus: rates, routes, and cofactors. Epidemiol Rev 18 :137–148.

  • 12

    Murrill CS, Weeks H, Castrucci BC, Weinstock HS, Bell BP, Spruill C, Gwinn M, 2001. Age specific trends in seroprevalence of HIV and Hepatitis B and C virus among infection drug users admitted to drug treatment in six US cities. Am J Public Health 92 :385–387.

    • Search Google Scholar
    • Export Citation
  • 13

    Ockenga J, Stoll M, Tillmann HL, Trautwein C, Manns MP, Schmidt RE, 1997. Coinfection of hepatitis B and C in HIV-infected patients. Wien Med Wochenschr 147 :439–442.

    • Search Google Scholar
    • Export Citation
  • 14

    Opravil M, Hunziker R, Luthy R, Grob PJ, 1998. Chronic hepatitis B and C in HIV-infected patients. Dtsch Med Wochenschr 123 :753–760.

  • 15

    Yee TT, Griffioen A, Sabin CA, Dusheiko G, Lee CA, 2000. The natural history of HCV in a cohort of haemophilic patients infected between 1961 and 1985. Gut 47 :845–851.

    • Search Google Scholar
    • Export Citation
  • 16

    American Liver Foundation, 2003. Why integrate hepatitis C information into HIV/AIDS prevention education? Hepatitis Integration Training Manual. New York, American Liver Foundation 3.1–3.11.

  • 17

    Macias J, Pineda JA, Leal M, Abad MA, Garcia-Pesquera F, Delgado J, Gallardo JA, Sanchez-Quijano A, Lissen E, 1998. Influence of hepatitis C virus infection on the mortality of antiretroviral-treated patients with HIV disease. Eur J Clin Microbiol Infect Dis 17 :167–170.

    • Search Google Scholar
    • Export Citation
  • 18

    Haydon GH, Flegg PJ, Blair CS, Brettle RP, Burns SM, Hayes PC, 1998. The impact of chronic hepatitis C virus infection on HIV disease and progression in intravenous drug users. Eur J Gastroenterol Heapatol 10 :485–489.

    • Search Google Scholar
    • Export Citation
  • 19

    Wright TL, Hollander H, Pu X, Held MJ, Lipson P, Quan S, Polito A, Thaler MM, Bacchetti P, Scharschmidt BF, 1994. Hepatitis C in HIV-infected patients with or without AIDS: prevalence and relationship to patient survival. Hepatology 20 :1152–1155.

    • Search Google Scholar
    • Export Citation
  • 20

    Macias J, Pineda JA, Lozano F, Corzo JE, Ramos A, Leon E, Garcia-Garcia JA, Fernandez-Rivera J, Mira JA, Gómez-Mateos J, 2003. Impaired recovery of CD4+ cell counts following highly active antiretroviral therapy in drug-naive patients coinfected with human immunodeficiency virus and hepatitis C virus. Eur J Clin Microbiol Infect Dis 22 :675–680.

    • Search Google Scholar
    • Export Citation
  • 21

    De Luca A, Bugarini R, Lepri AC, Puoti M, Girardi E, Antinori A, Poggio A, Pagano G, Tositti G, Cadeo G, Macor A, Toti M, d’Arminio Monforte A, Italian Cohort Naive Antiretroviral Study Group, 2002. Coinfection with hepatitis viruses and outcome of initial antiretroviral regimens in previously naive HIV-infected subjects. Arch Intern Med 162 :2125–2132.

    • Search Google Scholar
    • Export Citation
  • 22

    Piroth L, Duong M, Quantin C, Abrahamowicz M, Michardiere R, Aho LS, Grappin M, Buisson M, Waldner A, Portier H, Chavanet P, 1998. Does hepatitis C virus coinfection accelerate clinical and immunological evolution of HIV-infected patients? AIDS 12 :381–388.

    • Search Google Scholar
    • Export Citation
  • 23

    Gómez M, Velasquez M, Hunter RF, 1997. Profile of a Puerto Rican HIV infected population. Bol Assoc Med P R 89 :111–116.

  • 24

    Jeckel J, Elmore J, Katz D, 1996. Statistical inference and hypothesis testing. Epidemiology Biostatistics and Preventive Medicine. Philadelphia: WB Saunders Company, 128–135.

  • 25

    Armitage P, Berry G, 1988. Survival analysis. Statistical Methods in Medical Research. Oxford: Blackwell Scientific Publication, 421–439.

  • 26

    Sulkowski MS, Thomas D, 2003. Hepatitis C in the HIV-infected person. Ann Intern Med 138 :197–207.

  • 27

    Klein MB, Lalonde RG, Suissa S, 2003. The impact of hepatitis C virus coinfection on HIV progression before and after highly active antiretroviral therapy. J Acquir Immune Defic Syndr 33 :365–372.

    • Search Google Scholar
    • Export Citation
  • 28

    The Distance Learning Center for Addiction Studies, 2004. Distance Learning Course. Hepatitis C-Information for Counselers. Available from http://www.dlcas.com/states.htm

  • 29

    Caloir S, Spencer J, Nresnahan M, Brownstein A, 2003. American Liver Foundation and CDC. Hepatitis Integration Training Manual. Available from http://www.cdc.gov/ncidod/diseases/hepatitis/resource/training/hitm_manual.pdf

  • 30

    Poynard T, Bedossa P, Opolon P, 1997. Natural history of liver fibrosis progression in patients with chronic hepatitis C, the OBSVIRC, METAVIR, CLINIVIR and DOSVIRC groups. Lancet 349 :825–832.

    • Search Google Scholar
    • Export Citation
  • 31

    Zylberberg H, Pol S, 1996. Reciprocal interaction between human immunodeficiency virus and hepatitis C virus infections. Clin Infect Dis 23 :1117–1125.

    • Search Google Scholar
    • Export Citation
  • 32

    Bonacini M, Puoti M, 2000. Hepatitis C in patients with human immunodeficiency virus infection: diagnosis, natural history, meta-analysis of sexual and vertical transmission and therapeutic issues. Arch Intern Med 160 :3365–3373.

    • Search Google Scholar
    • Export Citation
  • 33

    Sanchez-Quijano A, Andreu J, Gavilan F, Luque F, Abad MA, Soto B, Munoz J, Aznar JM, Leal M, Lissen E, 1995. Influence of HCV type 1 infection on the natural course of chronic parenterally acquired hepatitis C. Eur J Clin Microbiol Infect Dis 14 :949–953.

    • Search Google Scholar
    • Export Citation
  • 34

    Verucchi G, Calza L, Manfredi R, Chiodo F, 2004. Human immunodeficiency virus and hepatitis C virus coinfection: epidemiology, natural history, therapeutic options and clinical management. Infection 33 :33–46.

    • Search Google Scholar
    • Export Citation
  • 35

    Rios-Olivares E, Yamamura Y, Gómez MA, Guzmán L, Rodríguez N, Fernández D, Hunter Mellado R, 2001. HCV genotype analysis in HCV-HIV coinfected Puerto Ricans who are injecting drug users: undetermined and mixed infections. Cell Mol Biol 47 :1017–1025.

    • Search Google Scholar
    • Export Citation
  • 36

    Sabin CA, Telfer F, Phillips AN, Bhaganis S, Lee CA, 1997. The association between hepatitis C virus genotype and human immunodeficiency virus disease progression in a cohort of hemophilic men. J Infect Dis 175 :164–168.

    • Search Google Scholar
    • Export Citation
  • 37

    Torriani FJ, Rodriguez-Torres M, Rockstroh JK, Lissen E, Gonzalez-Garcia J, Lazzarin A, Carosi G, Sasadeusz J, Katlama C, Montaner J, Sette H Jr, Passe S, De Pamphilis J, Duff F, Schrenk UM, Dieterich DT, Study Group APRICOT, 2004. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection in HIV infected patients. N Engl J Med 351 :438–450.

    • Search Google Scholar
    • Export Citation
  • 38

    Chung RT, Andersen J, Volberding P, Robbins GK, Liu T, Sherman KE, Peters MG, Koziel MJ, Bhan AK, Alston B, Colquhoun D, Nevin T, Harb G, van der Horst C, AIDS Clinical Trials Group A5071 Study Team, 2004. Peginterferon alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons. N Engl J Med 351 :451–459.

    • Search Google Scholar
    • Export Citation
  • 39

    Rutschmann OT, Negro F, Hirschel B, Hadengue A, Anwar D, Perrin LH, 1998. Impact of treatment with human immunodeficiency virus (HIV) protease inhibitors on hepatitis C viremia in patients coinfected with HIV. J Infect Dis 177 :783–785.

    • Search Google Scholar
    • Export Citation
  • 40

    Ragni MV, Bontempo FA, 1999. Increase in hepatitis C viral load in hemophiliacs during treatment with highly active antiretroviral therapy. J Infect Dis 180 :2027–2029.

    • Search Google Scholar
    • Export Citation
  • 41

    Hayashi K, Fukuda Y, Nakano I, Katano Y, Yokozaki S, Toyoda H, Takamatsu J, Hayakawa T, 2000. Poor response to interferon treatment for chronic hepatitis C in human immunodeficiency virus-infected hemophiliacs. Hemophil 6 :677–681.

    • Search Google Scholar
    • Export Citation
  • 42

    Prestileo T, Mazzola G, Di Lorenzo F, Colletti P, Vitale F, Ferraro D, Di Stefano R, Camma C, Craxi A, 2000. Response-adjusted alpha interferon therapy for chronic hepatitis C in HIV infected patients. Int J Antimicrob Agents 16 :373–378.

    • Search Google Scholar
    • Export Citation
  • 43

    De Franceschi L, Fattovich G, Turrini F, Ayi K, Brugnara C, Manzato F, Noventa F, Stanzial AM, Solero P, Corrocher R, 20000. Hemolytic anemia induced by ribavirin therapy in patients with chronic hepatitis C virus: role of membrane oxidative damage. Hepatology 31 :997–1004.

    • Search Google Scholar
    • Export Citation
  • 44

    Zylberberg H, Pialoux G, Carnot F, Landau A, Brechot C, Pol S, 1998. Rapidly evolving hepatitis C virus related cirrhosis in human immunodeficiency virus-infected patient receiving triple antiretroviral therapy. Clin Infect Dis 27 :1255–1258.

    • Search Google Scholar
    • Export Citation
  • 45

    Saves M, Raffi F, Clevenbergh P, Marchou B, Waldner- Combernoux A, Morlat P, Le Moing V, Riviere C, Chene G, Leport C, 2000. Hepatitis B or hepatitis C virus infection is a risk factor for severs hepatic cytolysis after initiation of protease inhibitor-containing antiretroviral regimen in human immunodeficiency virus-infected patients. The APROCO study group. Antimicrop Agents Chemother 44 :3451–3455.

    • Search Google Scholar
    • Export Citation
  • 46

    Vogt MW, Hartshorn KL, Furman PA, Chou TC, Fyfe JA, Coleman LA, Crumpacker C, Schooley RT, Hirsch MS, 1987. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science 235 :1376–1379.

    • Search Google Scholar
    • Export Citation
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MORBIDITY AND MORTALITY PROFILE OF HUMAN IMMUNODEFICIENCY VIRUS–INFECTED PATIENTS WITH AND WITHOUT HEPATITIS C CO-INFECTION

ANGEL M. MAYORRetrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

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MARIA A. GOMEZRetrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

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DIANA M. FERNANDEZRetrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

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EDDY RIOS-OLIVARESRetrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

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JAMES C. THOMASRetrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

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ROBERT F. HUNTERRetrovirus Research Center, and Department of Microbiology, Universidad Central del Caribe, School of Medicine, Bayamón, Puerto Rico; Epidemiology Department, School of Public Health, University of North Carolina, Chapel Hill, North Carolina

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Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection is an important and frequent scenario, predominantly in injecting drug users (IDUs). The present study evaluated morbidity and mortality variation in HIV-infected patients with and without HCV co-infection. Co-infection prevalence was determined in 356 HIV-infected persons. Their clinical manifestations, laboratory findings, risk factors, HIV therapies, and mortality rates were evaluated. The prevalence of HCV was 54% in the overall group and 81% in IDUs, with a predominance of HCV genotype 1. Mortality rates were similar in patients with and without co-infection; however, co-infected patients had significantly higher liver damage as a cause of mortality when compared with those who were not co-infected. The high prevalence of HCV and an emerging mortality from liver diseases showed the significance of this co-infection in the HIV epidemic. Primary and secondary prevention are necessary to reduce the expanding impact of HCV infection in HIV patients.

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