Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Knipling EF, Laven H, Craig GB, Pal R, Kitzmiller JB, Smith CN, Brown AW, 1968. Genetic control of insects of public health importance. Bull World Health Organ 38 :421ā438.
-
2
Pal R, 1974. WHO/ICMR programme of genetic control of mosquitoes in India. Pal R, Whitten MJ, eds. The Use of Genetics in Insect Control. Amsterdam: Elsevier, 73ā95.
-
3
Lorimer N, Lounibos LP, Petersen JL, 1976. Field trials with a translocation homozygote in Aedes aegypti for population replacement. J Econ Entomol 69 :405ā409.
-
4
Yasuno M, Mcdonald WW, Curtis CF, Grover KK, Rajagopalan PK, Sharma LS, Sharma VP, Singh D, Singh KRP, Agarwal HV, Kazmi SJ, Menon PKB, Menon R, Razdan RK, Samuel D, Vaidyanathan V, 1978. A control experiment with chemo-sterilized male Culex pipiens fatigans Wied in a village near Delhi surrounded by a breeding-free zone. Jpn J Sanit Zool 29 :325ā343.
-
5
Baker RH, Reisen WK, Sakai RK, Hayes CG, Aslamkhan M, Saifuddin UT, Mahmood F, Perveen A, Javed S, 1979. Field assessment of mating competitiveness of male Culex tritaenio-rhynchus carrying a complex chromosomal aberration. Ann Entomol Soc Am 72 :751ā758.
-
6
Asman SM, McDonald PT, Prout T, 1981. Field studies of genetic control systems for mosquitoes. Annu Rev Entomol 26 :289ā318.
-
7
Curtis CF, 1985. Genetic control of insect pests: growth industry or lead balloon? Biol J Linn Soc 26 :359ā374.
-
8
Robinson AS, Franz G, Atkinson PW, 2004. Insect transgenesis and its potential role in agriculture and human health. Insect Biochem Mol Biol 34 :113ā120.
-
9
Curtis CF, Graves PM, 1988. Methods for replacement of malaria vector populations. J Trop Med Hyg 91 :43ā48.
-
10
Morris AC, Eggleston P, Crampton JM, 1989. Genetic transformation of the mosquito Aedes aegypti by micro-injection of DNA. Med Vet Entomol 3 :1ā7.
-
11
Alphey L, Ben BC, Billingsley P, Coetzee M, Crisanti A, Curtis C, Eggleston P, Godfray C, Hemingway J, Jacobs-Lorena M, James AA, Kafatos FC, Mukwaya LG, Paton M, Powell JR, Schneider W, Scott TW, Sina B, Sinden R, Sinkin S, Spielman A, ToureĢ Y, Collins FH, 2002. Malaria control with genetically manipulated insect vectors. Science 298 :119ā121.
-
12
Catteruccia F, Godfray HCJ, Crisanti A, 2003. Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. Science 299 :1225ā1227.
-
13
Irvin N, Hoddle MS, OāBrochta DA, Carey B, Atkinson PW, 2004. Assessing fitness costs for transgenic Aedes aegypti expressing the GFP marker and transposase genes. Proc Natl Acad Sci USA 101 :891ā896.
-
14
Moreira LA, Wang J, Collins FH, Jacobs-Lorena M, 2004. Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development. Genetics 166 :1337ā1341.
-
15
James AA, 2005. Gene drive systems in mosquitoes: rules of the road. Trends Parasitol 21 :64ā67.
-
16
Sandler L, Novitski E, 1957. Meiotic drive as an evolutionary force. Am Nat 91 :105ā110.
-
17
Lyttle TW, 1993. Cheater sometimes prosper: distortion of men-delian segregation by meiotic drive. Trends Genet 9 :205ā210.
-
18
Crow JF, 1999. Unmasking a cheating gene. Science 283 :1651ā1652.
-
19
Palopoli MF, Wu CI, 1996. Rapid evolution of a coadapted gene complex: evidence from the segregation distorter (SD) system of meiotic drive in Drosophila melanogaster.Genetics 143 :1675ā1688.
-
20
Craig GB, Hickey WA, VandeHey RC, 1960. An inherited male-producing factor in Aedes aegypti.Science 23 :1887ā1889.
-
21
Sweeny TL, Barr AR, 1978. Sex ratio distortion caused by meiotic drive in a mosquito, Culex pipiens L. Genetics 88 :427ā446.
-
22
Newton ME, Wood RJ, Southern DI, 1978. Cytological mapping of the M and D loci in the mosquito, Aedes aegypti (L.). Genetica 48 :137ā143.
-
23
Hickey WA, Craig GB, 1966. Distortion of sex ratio in populations of Aedes aegypti.Can J Genet Cytol 8 :260ā278.
-
24
Wood RJ, Ouda NA, 1987. The genetic basis of resistance and sensitivity to the meiotic drive gene D in the mosquito Aedes aegypti L. Genetica 72 :69ā79.
-
25
Wood RJ, Cook LM, Hamilton A, Whitelaw A, 1977. Transporting the marker gene re (red eye) into a laboratory cage population of Aedes aegypti (Diptera: Culicidae), using meiotic drive at the MD locus. J Med Entomol 14 :461ā464.
-
26
Curtis CF, Grover KK, Suguna SG, Uppal DK, Dietz K, Agarwal HV, Kazmi SJ, 1976. Comparative field cage tests of the population suppressing efficiency of three genetic control systems for Aedes aegypti.Heredity 36 :11ā29.
-
27
Suguna SG, Kazami SJ, Curtis CF, 1977. Sex-ratio distorter translocation homozygotes in Aedes aegypti.Genetica 47 :125ā133.
-
28
Mori A, Chadee DD, Graham DH, Severson DW, 2004. Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera: Culicidae). J Med Entomol 41 :1027ā1033.
-
29
Hickey WA, Craig GB, 1966a. Genetic distortion of sex ratio in a mosquito Aedes aegypti.Genetics 53 :1177ā1196.
-
30
Severson DW, Meece JK, Lovin DD, Saha G, Morlais I, 2002. Linkage map organization of expressed sequence tags and sequence tagged sites in the mosquito, Aedes aegypti.Insect Mol Biol 11 :371ā378.
-
31
Severson DW, 1997. RFLP analysis of insect genomes. Crampton JM, Beard CB, Louis C, eds. The Molecular Biology of Insect Disease Vectors: A Methods Manual. London: Chapman and Hall, 309ā320.
-
32
Wood RJ, Newton ME, 1991. Sex-ratio distortion caused by meiotic drive in mosquitoes. Am Nat 137 :379ā391.
-
33
Wood RJ, 1976. Between-family variation in sex ratio in the Trinidad (T-30) strain of Aedes aegypti (L.) indicating differences in sensitivity to the meiotic drive gene MD.Genetica 46 :345ā361.
-
34
Kusano A, Staber C, Ganetzky B, 2002. Segregation distortion induced by wild-type RanGAP in Drosophila.Proc Natl Acad Sci USA 99 :6866ā6870.
-
35
Merrill C, Bayraktaroglu L, Kusano A, Ganetzky B, 1999. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila.Science 283 :1742ā1745.
-
36
Sazer S, Dasso M, 2000. The Ran decathlon: multiple roles of Ran. J Cell Sci 113 :1111ā1118.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 13 | 13 | 5 |
| Full Text Views | 268 | 90 | 0 |
| PDF Downloads | 69 | 27 | 0 |
CAGE TRIALS USING AN ENDOGENOUS MEIOTIC DRIVE GENE IN THE MOSQUITO AEDES AEGYPTI TO PROMOTE POPULATION REPLACEMENT
SUNG-JAE CHA
SUNG-JAE CHA
Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana; Department of Life Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies
Search for other papers by SUNG-JAE CHA in
Current site
Google Scholar
PubMed
Search for other papers by SUNG-JAE CHA in
Current site
Google Scholar
PubMed
AKIO MORI
AKIO MORI
Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana; Department of Life Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies
Search for other papers by AKIO MORI in
Current site
Google Scholar
PubMed
Search for other papers by AKIO MORI in
Current site
Google Scholar
PubMed
DAVE D. CHADEE
DAVE D. CHADEE
Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana; Department of Life Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies
Search for other papers by DAVE D. CHADEE in
Current site
Google Scholar
PubMed
Search for other papers by DAVE D. CHADEE in
Current site
Google Scholar
PubMed
DAVID W. SEVERSON
DAVID W. SEVERSON
Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana; Department of Life Sciences, University of the West Indies, St. Augustine, Trinidad and Tobago, West Indies
Search for other papers by DAVID W. SEVERSON in
Current site
Google Scholar
PubMed
Search for other papers by DAVID W. SEVERSON in
Current site
Google Scholar
PubMed
Control of arthropod-borne diseases based on population replacement with genetically modified non-competent vectors has been proposed as a promising alternative to conventional control strategies. Due to likely fitness costs associated with vectors manipulated to carry anti-pathogen effector genes, the effector genes will need to be coupled with a strong drive system to rapidly sweep them into natural populations. Endogenous meiotic drive systems have strong and stable population replacement potential, and have previously been reported in two mosquito species: Aedes aegypti and Culex pipiens. To investigate the influence of an endogenous meiotic drive gene on Ae. aegypti population dynamics, we established three experimental population types that were initiated with 100%, 10%, and 1% male mosquitoes carrying a strong meiotic driver (T37 strain) and 100% sensitive females (RED strain), respectively. Among the 100% and 10% populations, early generations were highly male biased, which reflected the effects of the meiotic driver, and remained more than 60% male by the F15. A genetic marker tightly linked with the meiotic driver on chromosome 1 showed strong selection for the T37 strain-specific allele. Similar but reduced effects of the meiotic driver were also observed in the 1% populations. These results suggest that release of Ae. aegypti males carrying a strong meiotic driver into drive sensitive populations can be an effective tool for population replacement, and provide a foundation for additional studies including both experimental populations and simulations by mathematical modeling.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Knipling EF, Laven H, Craig GB, Pal R, Kitzmiller JB, Smith CN, Brown AW, 1968. Genetic control of insects of public health importance. Bull World Health Organ 38 :421ā438.
-
2
Pal R, 1974. WHO/ICMR programme of genetic control of mosquitoes in India. Pal R, Whitten MJ, eds. The Use of Genetics in Insect Control. Amsterdam: Elsevier, 73ā95.
-
3
Lorimer N, Lounibos LP, Petersen JL, 1976. Field trials with a translocation homozygote in Aedes aegypti for population replacement. J Econ Entomol 69 :405ā409.
-
4
Yasuno M, Mcdonald WW, Curtis CF, Grover KK, Rajagopalan PK, Sharma LS, Sharma VP, Singh D, Singh KRP, Agarwal HV, Kazmi SJ, Menon PKB, Menon R, Razdan RK, Samuel D, Vaidyanathan V, 1978. A control experiment with chemo-sterilized male Culex pipiens fatigans Wied in a village near Delhi surrounded by a breeding-free zone. Jpn J Sanit Zool 29 :325ā343.
-
5
Baker RH, Reisen WK, Sakai RK, Hayes CG, Aslamkhan M, Saifuddin UT, Mahmood F, Perveen A, Javed S, 1979. Field assessment of mating competitiveness of male Culex tritaenio-rhynchus carrying a complex chromosomal aberration. Ann Entomol Soc Am 72 :751ā758.
-
6
Asman SM, McDonald PT, Prout T, 1981. Field studies of genetic control systems for mosquitoes. Annu Rev Entomol 26 :289ā318.
-
7
Curtis CF, 1985. Genetic control of insect pests: growth industry or lead balloon? Biol J Linn Soc 26 :359ā374.
-
8
Robinson AS, Franz G, Atkinson PW, 2004. Insect transgenesis and its potential role in agriculture and human health. Insect Biochem Mol Biol 34 :113ā120.
-
9
Curtis CF, Graves PM, 1988. Methods for replacement of malaria vector populations. J Trop Med Hyg 91 :43ā48.
-
10
Morris AC, Eggleston P, Crampton JM, 1989. Genetic transformation of the mosquito Aedes aegypti by micro-injection of DNA. Med Vet Entomol 3 :1ā7.
-
11
Alphey L, Ben BC, Billingsley P, Coetzee M, Crisanti A, Curtis C, Eggleston P, Godfray C, Hemingway J, Jacobs-Lorena M, James AA, Kafatos FC, Mukwaya LG, Paton M, Powell JR, Schneider W, Scott TW, Sina B, Sinden R, Sinkin S, Spielman A, ToureĢ Y, Collins FH, 2002. Malaria control with genetically manipulated insect vectors. Science 298 :119ā121.
-
12
Catteruccia F, Godfray HCJ, Crisanti A, 2003. Impact of genetic manipulation on the fitness of Anopheles stephensi mosquitoes. Science 299 :1225ā1227.
-
13
Irvin N, Hoddle MS, OāBrochta DA, Carey B, Atkinson PW, 2004. Assessing fitness costs for transgenic Aedes aegypti expressing the GFP marker and transposase genes. Proc Natl Acad Sci USA 101 :891ā896.
-
14
Moreira LA, Wang J, Collins FH, Jacobs-Lorena M, 2004. Fitness of anopheline mosquitoes expressing transgenes that inhibit Plasmodium development. Genetics 166 :1337ā1341.
-
15
James AA, 2005. Gene drive systems in mosquitoes: rules of the road. Trends Parasitol 21 :64ā67.
-
16
Sandler L, Novitski E, 1957. Meiotic drive as an evolutionary force. Am Nat 91 :105ā110.
-
17
Lyttle TW, 1993. Cheater sometimes prosper: distortion of men-delian segregation by meiotic drive. Trends Genet 9 :205ā210.
-
18
Crow JF, 1999. Unmasking a cheating gene. Science 283 :1651ā1652.
-
19
Palopoli MF, Wu CI, 1996. Rapid evolution of a coadapted gene complex: evidence from the segregation distorter (SD) system of meiotic drive in Drosophila melanogaster.Genetics 143 :1675ā1688.
-
20
Craig GB, Hickey WA, VandeHey RC, 1960. An inherited male-producing factor in Aedes aegypti.Science 23 :1887ā1889.
-
21
Sweeny TL, Barr AR, 1978. Sex ratio distortion caused by meiotic drive in a mosquito, Culex pipiens L. Genetics 88 :427ā446.
-
22
Newton ME, Wood RJ, Southern DI, 1978. Cytological mapping of the M and D loci in the mosquito, Aedes aegypti (L.). Genetica 48 :137ā143.
-
23
Hickey WA, Craig GB, 1966. Distortion of sex ratio in populations of Aedes aegypti.Can J Genet Cytol 8 :260ā278.
-
24
Wood RJ, Ouda NA, 1987. The genetic basis of resistance and sensitivity to the meiotic drive gene D in the mosquito Aedes aegypti L. Genetica 72 :69ā79.
-
25
Wood RJ, Cook LM, Hamilton A, Whitelaw A, 1977. Transporting the marker gene re (red eye) into a laboratory cage population of Aedes aegypti (Diptera: Culicidae), using meiotic drive at the MD locus. J Med Entomol 14 :461ā464.
-
26
Curtis CF, Grover KK, Suguna SG, Uppal DK, Dietz K, Agarwal HV, Kazmi SJ, 1976. Comparative field cage tests of the population suppressing efficiency of three genetic control systems for Aedes aegypti.Heredity 36 :11ā29.
-
27
Suguna SG, Kazami SJ, Curtis CF, 1977. Sex-ratio distorter translocation homozygotes in Aedes aegypti.Genetica 47 :125ā133.
-
28
Mori A, Chadee DD, Graham DH, Severson DW, 2004. Reinvestigation of an endogenous meiotic drive system in the mosquito, Aedes aegypti (Diptera: Culicidae). J Med Entomol 41 :1027ā1033.
-
29
Hickey WA, Craig GB, 1966a. Genetic distortion of sex ratio in a mosquito Aedes aegypti.Genetics 53 :1177ā1196.
-
30
Severson DW, Meece JK, Lovin DD, Saha G, Morlais I, 2002. Linkage map organization of expressed sequence tags and sequence tagged sites in the mosquito, Aedes aegypti.Insect Mol Biol 11 :371ā378.
-
31
Severson DW, 1997. RFLP analysis of insect genomes. Crampton JM, Beard CB, Louis C, eds. The Molecular Biology of Insect Disease Vectors: A Methods Manual. London: Chapman and Hall, 309ā320.
-
32
Wood RJ, Newton ME, 1991. Sex-ratio distortion caused by meiotic drive in mosquitoes. Am Nat 137 :379ā391.
-
33
Wood RJ, 1976. Between-family variation in sex ratio in the Trinidad (T-30) strain of Aedes aegypti (L.) indicating differences in sensitivity to the meiotic drive gene MD.Genetica 46 :345ā361.
-
34
Kusano A, Staber C, Ganetzky B, 2002. Segregation distortion induced by wild-type RanGAP in Drosophila.Proc Natl Acad Sci USA 99 :6866ā6870.
-
35
Merrill C, Bayraktaroglu L, Kusano A, Ganetzky B, 1999. Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila.Science 283 :1742ā1745.
-
36
Sazer S, Dasso M, 2000. The Ran decathlon: multiple roles of Ran. J Cell Sci 113 :1111ā1118.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 13 | 13 | 5 |
| Full Text Views | 268 | 90 | 0 |
| PDF Downloads | 69 | 27 | 0 |