DISEASE SEVERITY AND OUTCOME OF MELIOIDOSIS IN HIV COINFECTED INDIVIDUALS

WIRONGRONG CHIERAKUL Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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VANAPORN WUTHIEKANUN Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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WIPADA CHAOWAGUL Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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PREMJIT AMORNCHAI Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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ALLEN C. CHENG Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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NICHOLAS J. WHITE Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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NICHOLAS P. J. DAY Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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SHARON J. PEACOCK Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Medical Department, Sappasithiprasong Hospital, Ubon Ratchathani, Thailand; Menzies School of Health Research, Charles Darwin University, Darwin, and The Geelong Hospital, Barwon Health, Geelong Australia; Center for Clinical Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom

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This study examined whether coinfection with HIV and Burkholderia pseudomallei leads to altered disease severity or outcome associated with melioidosis. Coinfection was detected in only 8 of 524 (1.5%) adults with melioidosis in northeast Thailand. Clinical presentation and acute outcome were similar in HIV-positive and HIV-negative patients.

Author Notes

Reprint requests: Dr. Wirongrong Chierakul, Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, 420/6 Rajvithi Road, Bangkok, 10400, Thailand. Telephone: 66-2-354-1395, Fax: 66-2-354-9169, E-mail: alwcr@diamond.mahidol.ac.th.
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