IMPACT OF IVERMECTIN COMMUNITY-LEVEL TREATMENTS ON ELIMINATION OF ADULT ONCHOCERCA VOLVULUS WHEN INDIVIDUALS RECEIVE MULTIPLE TREATMENTS PER YEAR

EDDIE W. CUPP Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama

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MARY S. CUPP Department of Entomology and Plant Pathology, Auburn University, Auburn, Alabama

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A reanalysis of several published reports indicates that when community-wide biannual treatment disrupts transmission of new infection, a profound macrofilaricidal effect of ivermectin (Mectizan) occurs that is accelerated for individuals treated 4 times a year (4×/yr). The effect is particularly obvious on adult male worms and suggests that this gender is susceptible to repetitive treatment after transmission has been blocked or greatly reduced as a result of community treatment.

Author Notes

Reprint requests: Dr. Eddie W. Cupp, Department of Entomology and Plant Pathology, 301 Funchess Hall, Auburn University, Auburn, AL 36849-5413.
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