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-
1
Ajao OG, 1978. Malaria and post-operative fever. J Trop Med Hyg 81 :153–155.
-
2
Bruce-Chwatt LJ, 1972. Blood transfusion and tropical disease. Trop Dis Bull 69 :825–862.
-
3
Manson-Bahr PEC, Ball DR, 1987. Manson’s Tropical Diseases. 19th edition. London: Ballière-Tindall.
-
4
Neva FA, Brown HW, 1994. Basic Clinical Parasitology. Sixth edition. New York: Appleton and Lange.
-
5
Ali MS, Kadaru AGMY, Mustafa MS, 2004. Screening blood donors for malaria parasite in Sudan. Ethiop J Health Dev 18 :70–74.
-
6
Mollison PL, 1994. Blood Transfusion in Clinical Medicine. Ninth edition. Oxford, United Kingdom: Blackwell.
-
7
Dover AS, Schultz MG, 1971. Transfusion-induced malaria. Transfusion 11 :353–357.
-
8
Talib VH, Khurana SK, 1996. Haematology for Students. Complications of Blood Transfusion. Karachi, Pakistan.
-
9
Ali MS, Yousif AG, Mustafa MS, Ibrahim MS, 2005. Evaluation of laboratory procedures applied for malaria parasite screening of Sudanese blood donors. Clin Lab Sci 18 :69–73.
-
10
Schneider J, 1963. Chemoprophylaxis of tropical diseases transmitted by blood transfusion. Transfusion 6 :171.
-
11
Cheesbrough M, 1987. Medical Laboratory Manual for Tropical Countries. Second edition. Oxford, United Kingdom: Butter-worth.
-
12
Dacie JV, Lewis SM, 1984. Practical Haematology. Sixth edition. Edinburgh, United Kingdom: Churchill Livingstone.
-
13
Gramiccia G, 1964. Lessons learned during the final stages of malaria eradication in Europe. Riv Parassitol 25 :157.
-
14
Bruce-Chwatt LJ, 1982. Transfusion malaria revisited. Trop Dis Bull 79 :827–840.
-
15
Rosenberg R, Wirtz RA, Schneider I, Burge R, 1990. An estimation of the number of malaria sporozoites ejected by feeding mosquito. Trans R Soc Trop Med Hyg 84 :209–212.
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IN VITRO PROCESSING OF DONOR BLOOD WITH SULFADOXINE-PYRIMETHAMINE FOR ERADICATION OF TRANSFUSION-INDUCED MALARIA
MOHAMED S. M. ALI
MOHAMED S. M. ALI
Department of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan; Medicine, University of Khartoum, Khartoum, Sudan
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ABDUL G. M. Y. KADARU
ABDUL G. M. Y. KADARU
Department of Haematology, Faculty of Medical Laboratory Sciences, Al Neelain University, Khartoum, Sudan; Medicine, University of Khartoum, Khartoum, Sudan
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Transfusion-induced malaria is a problem because of the large number of parasites infused and the weakness of transfused patients. Screening of blood donors or treatment of transfused patients or prospective donors does not eliminate this hazard. It is essential to kill the parasite in vitro in the blood of donors before transfusion. A total of 4,484 blood donors were screened for malaria parasite microscopically using the Giemsa staining technique. Only 30 matched the inclusion criteria of this study. Blood samples were divided into four equal samples. Three concentrations of sulfadoxine-pyremthamine (SP) were added to 90 specimens, and none was added to 30 specimens (controls). Blood specimens were then tested by parasitic, biochemical, and hematologic techniques on the day of collection and after 24 and 48 hours of storage in a blood bank refrigerator. The reduction of malaria parasites was proportional to the concentrations of SP and to the storage period. Blood samples without SP had steady number of the parasites. The lethal dose of SP (the dose that killed 99% of the malaria parasites within 24 hours) was 179.65 μg/L and was highly effective within the 24-hour storage period. This dose did not affect constituents of the stored blood. Thus, for eradication of transfusion-induced malaria by in vitro processing of donors blood, SP is a safe and effective drug. It is recommended that optimal doses of SP be added to donated blood prior to phlebotomy.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
Ajao OG, 1978. Malaria and post-operative fever. J Trop Med Hyg 81 :153–155.
-
2
Bruce-Chwatt LJ, 1972. Blood transfusion and tropical disease. Trop Dis Bull 69 :825–862.
-
3
Manson-Bahr PEC, Ball DR, 1987. Manson’s Tropical Diseases. 19th edition. London: Ballière-Tindall.
-
4
Neva FA, Brown HW, 1994. Basic Clinical Parasitology. Sixth edition. New York: Appleton and Lange.
-
5
Ali MS, Kadaru AGMY, Mustafa MS, 2004. Screening blood donors for malaria parasite in Sudan. Ethiop J Health Dev 18 :70–74.
-
6
Mollison PL, 1994. Blood Transfusion in Clinical Medicine. Ninth edition. Oxford, United Kingdom: Blackwell.
-
7
Dover AS, Schultz MG, 1971. Transfusion-induced malaria. Transfusion 11 :353–357.
-
8
Talib VH, Khurana SK, 1996. Haematology for Students. Complications of Blood Transfusion. Karachi, Pakistan.
-
9
Ali MS, Yousif AG, Mustafa MS, Ibrahim MS, 2005. Evaluation of laboratory procedures applied for malaria parasite screening of Sudanese blood donors. Clin Lab Sci 18 :69–73.
-
10
Schneider J, 1963. Chemoprophylaxis of tropical diseases transmitted by blood transfusion. Transfusion 6 :171.
-
11
Cheesbrough M, 1987. Medical Laboratory Manual for Tropical Countries. Second edition. Oxford, United Kingdom: Butter-worth.
-
12
Dacie JV, Lewis SM, 1984. Practical Haematology. Sixth edition. Edinburgh, United Kingdom: Churchill Livingstone.
-
13
Gramiccia G, 1964. Lessons learned during the final stages of malaria eradication in Europe. Riv Parassitol 25 :157.
-
14
Bruce-Chwatt LJ, 1982. Transfusion malaria revisited. Trop Dis Bull 79 :827–840.
-
15
Rosenberg R, Wirtz RA, Schneider I, Burge R, 1990. An estimation of the number of malaria sporozoites ejected by feeding mosquito. Trans R Soc Trop Med Hyg 84 :209–212.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 445 | 375 | 21 |
| Full Text Views | 201 | 10 | 0 |
| PDF Downloads | 34 | 10 | 2 |