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-
1
Rizzetto M, Canese MG, Arico S, Crinelo O, Trepo C, Bonino F, Verme G, 1977. Immunofluorescence detection of a new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and serum of HBsAg carriers. Gut 18 :997–1003.
-
2
Gaeta GB, Stroffolini T, Chiaramonte M, Ascione T, Stornaiuolo G, Lobello S, Sagnelli E, Brunetto MR, Rizzeto M, 2003. Chronic hepatitis D: a vanishing disease? An Italian multicenter study. Hepatology 32 :824–827.
-
3
Bensabath G, Hadler SC, Soares MC, Fields H, Dias LB, Popper H, Maynard JE, 1987. Hepatitis delta virus infection and Labrea hepatitis. Prevalence and role in fulminant hepatitis in the Amazon Basin. JAMA 258 :479–483.
-
4
Bensabath G, Dias LB, 1983. Hepatite de Lábrea e outras hepatites em Sena Madureira, Acre e Boca do Acre, Amazonas, Brasil. Rev Inst Med Trop Sao Paulo 25 :182–194.
-
5
Andrade ZA, Lesbordes JL, Ravisse P, Parana R, Prata A, Barberino JS, Trepo C, 1992. Fulminant hepatitis with microvesicular steatosis (a histologic comparison of cases occurring in Brazil—Labrea hepatitis—and in central Africa—Bangui hepatitis). Rev Soc Bras Med Trop. 25 :155–160.
-
6
Lesbordes JL, Ravisse P, Georges AJ, Chevallier P, Pichoud C, Vitvitski L, Trepo C, 1987. Studies on the role of HDV in an outbreak of fulminant hepatitis in Bangui (Central African Republic). Prog Clin Biol Res 234 :451–459.
-
7
Kaneko S, Feinstone SM, Miller RH, 1989. Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique. J Clin Microbiol 27 :1930–1933.
-
8
Sitnik R, Pinho JR, Bertolini DA, Bernardini AP, da Silva LC, Carrilho FJ, 2004. Hepatitis B virus genotypes and precore and core mutants in Brazilian patients. J Clin Microbiol 42 :2455–2460.
-
9
Sanger F, Nicklen S, Coulson AR, 1992. DNA sequencing with chain-terminating inhibitors. Proc Nat Acad Sci USA 74 :5463–5467.
-
10
Erhardt A, Knuth R, Sagir A, Kirschberg O, Heintges T, Haussinger D, 2003. Socioepidemiological data on hepatitis delta in a German university clinic: increase in patients from Eastern Europe and the former Soviet Union. Z Gastroenterol 41 :523–526.
-
11
Braga WS, Brasil LM, de Souza RA, Castilho Mda C, da Fonseca JC, 2001. Ocorrencia da infecção pelo vírus da hepatite B (VHB) e delta (VHD) em sete grupos indígenas do Estado do Amazonas. Rev Soc Bras Med Trop 34 :349–355.
-
12
de Paula VS, Arruda ME, Vitral CL, Gaspar AM, 2001. Seroprevalence of viral hepatitis in riverine communities from the Western region of the Brazilian Amazon Basin. Mem Inst Oswaldo Cruz 96 :1123–1128.
-
13
Ribeiro LC, Souto FJ, 2000. Hepatite delta no estado de Mato Grosso: apresentação de cinco casos. Rev Soc Bras Med Trop 33 :599–602.
-
14
Manock SR, Kelley PM, Hyams KC, Douce R, Smalligan RD, Watts DM, Sharp TW, Casey JL, Gerin JL, Engle R, Alava-Alprecht A, Martinez CM, Bravo NB, Guevara AG, Russell KL, Mendoza W, Vimos C, 2000. An outbreak of fulminant hepatitis delta in the Waorani, an indigenous people of the Amazon basin of Ecuador. Am J Trop Med Hyg 63 :209–213.
-
15
Nakano T, Shapiro CN, Hadler SC, Casey JL, Mizokami M, Orito E, Robertson BH, 2001. Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela. J Gen Virol 82 :2183–2189.
-
16
Casey JL, Brown TL, Colan EJ, Wignall FS, Gerin JL, 1993. A genotype of hepatitis D virus that occurs in northern South America. Proc Natl Acad Sci USA 90 :9016–9020.
-
17
Quintero A, Uzcategui N, Loureiro CL, Villegas L, Illarramendi X, Guevara ME, Ludert JE, Blitz L, Liprandi F, Pujol FH, 2001. Hepatitis delta virus genotypes III and I circulate associated with hepatitis B virus genotype F in Venezuela. J Med Virol 64 :356–359.
-
18
Blitz L, Pujol FH, Swenson PD, Porto L, Atencio R, Araujo M, Costa L, Monsalve DC, Torres JR, Fields HA, Lambert S, van Geyt C, Norder H, Magnius LO, Echevarria JM, Stuyver L, 1998. Antigenic diversity of hepatitis B virus strains of genotype F in Amerindians and other population groups from Venezuela. J Clin Microbiol 36 :648–651.
-
19
Magnius LO, Norder H, 1995. Subtypes, genotypes and molecular epidemiology of hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology 38 :24–34.
-
20
Chen YC, Sheen IS, Chu CM, Liaw YF, 2002. Prognosis following spontaneous HbsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology 123 :1084–1089.
-
21
Chulanov VP, Shipulin GA, Schaefer S, Gerlich WH, 2003. Kinetics of HBV DNA and HBsAg in acute hepatitis B patients with and without coinfection by other hepatitis viruses. J Med Virol 69 :313–323.
-
22
Fonseca JC, 2002. Hepatitis D. Rev Soc Bras Med Trop 35 :181–190.
-
23
Cheng Q, Jayan GC, Casey JL, 2003. Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigen. J Virol 77 :7786–7795.
-
24
Ghuman HK, Kaur S, 1995. Delta-hepatitis. Indian J Pediatr 62 :691–693.
-
25
Rizzetto M, 1990. Hepatitis delta: the virus and disease. J Hepatol 11 :S145–S148.
-
26
Parana R, Lyra L, Trepo C, 1999. Intravenous vitamin complexes used in sporting activities and transmission of HCV in Brazil. Am J Gastroenterol 94 :857–858.
-
27
Parana R, Vitvitski L, Andrade Z, Trepo C, Cotrim H, Bertillon P, Silva F, Silva L, de Oliveira IR, Lyra L, 1999. Acute sporadic non A, non B hepatitis in northeastern Brazil: etiology and natural history. Hepatology 30 :289–293.
-
28
Costa E, 1932. Hepatite na Região do Boca do Acre. Gaz Med Bahia 3 :148–175.
-
29
Lesbordes JL, Ravisse P, Georges AJ, Beuzit Y, Ave P, Enamra D, Meunier DM, Georges MC, Gonzalez JP, Chevalier P, Trepo C, 1987. Le role du virus delta dans les hepatites fulminantes en Afrique Centrale. Ann Med Interne (Paris) 138 :199–201.
-
30
Casey JL, Niro GA, Engle RE, Vega A, Gomez H, McCarthy M, Watts DM, Hyams KC, Gerin JL, 1996. Hepatitis B virus (HBV)/hepatitis D. virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon basin: the roles of HDV genotype III and HBV genotype F. J Infect Dis 174 :920–926.
-
31
Langon T, Fillon S, Pichoud C, Hantz O, Trepo C, Kay A, 1998. Analysis of a hepatitis delta virus isolate from the Central African Republic. Res Virol 149 :171–185.
-
32
Tang JR, Hantz O, Vitvitski L, Lamelin JP, Parana R, Cova L, Lesbordes JL, Trepo C, 1993. Discovery of a novel point mutation changing the HDAg expression of a hepatitis delta virus isolate from Central African Republic. J Gen Virol 74 :1827–1835.
-
33
Parana R, Gerard F, Lesbordes JL, Pichoud C, Vitvitski L, Lyra LG, Trepo C, 1995. Serial transmission of spongiocytic hepatitis to woodchucks (a possible association with a specific delta strain). J. Hepatol 22 :468–473.
-
34
Zhang YY, Tsega E, Hansson BG, 1996. Phylogenetic analysis of hepatitis D viruses indicating a new genotype I subgroup among African isolates. J Clin Microbiol 34 :3023–3030.
-
35
Radjef N, Ivaniushina V, Anais P, Trinchet J, Deny P, 2001. Hepatitis D virus (HDV) genome analysis from Africa suggest the existence of more than three worldwide HDV genotypes. J Hepatol 34 (Suppl 1):120.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 153 | 72 | 13 |
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HIGH PREVALENCE OF HEPATITIS B VIRUS AND HEPATITIS D VIRUS IN THE WESTERN BRAZILIAN AMAZON
SEBASTIÃO VIANA
SEBASTIÃO VIANA
Postgraduate Program in Tropical Medicine, University of Brasília, Brasília, Brazil; Gastro-Hepatology Unit, Federal University of Bahia, Salvador, Brazil; Laboratory of Viral Hepatitis, Department of Virology, Adolfo Lutz Institute, Sao Paulo, Brazil
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RAYMUNDO PARANÁ
RAYMUNDO PARANÁ
Postgraduate Program in Tropical Medicine, University of Brasília, Brasília, Brazil; Gastro-Hepatology Unit, Federal University of Bahia, Salvador, Brazil; Laboratory of Viral Hepatitis, Department of Virology, Adolfo Lutz Institute, Sao Paulo, Brazil
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REGINA CÉLIA MOREIRA
REGINA CÉLIA MOREIRA
Postgraduate Program in Tropical Medicine, University of Brasília, Brasília, Brazil; Gastro-Hepatology Unit, Federal University of Bahia, Salvador, Brazil; Laboratory of Viral Hepatitis, Department of Virology, Adolfo Lutz Institute, Sao Paulo, Brazil
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ADRIANA PARISE COMPRI
ADRIANA PARISE COMPRI
Postgraduate Program in Tropical Medicine, University of Brasília, Brasília, Brazil; Gastro-Hepatology Unit, Federal University of Bahia, Salvador, Brazil; Laboratory of Viral Hepatitis, Department of Virology, Adolfo Lutz Institute, Sao Paulo, Brazil
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VANISE MACEDO
VANISE MACEDO
Postgraduate Program in Tropical Medicine, University of Brasília, Brasília, Brazil; Gastro-Hepatology Unit, Federal University of Bahia, Salvador, Brazil; Laboratory of Viral Hepatitis, Department of Virology, Adolfo Lutz Institute, Sao Paulo, Brazil
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Severe cases of hepatitis caused by hepatitis B virus (HBV) or hepatitis D virus (HDV) are often seen in the Brazilian Amazon, but there is a paucity of epidemiologic studies on viral hepatitis in this area. Thus, a cross-sectional study to investigate the prevalence of markers for HBV and HDV was performed. Serum samples were collected after participants completed an epidemiologic questionnaire. Markers for HBV and HDV were analyzed with an enzyme-linked immunosorbent assay. The HBV genotype was determined by sequencing of the gene for hepatitis B surface antigen (HBsAg). Of 2,656 samples, 89 (3.3%) were positive for HBsAg and 1,628 (61.5%) were positive for IgG antibody to hepatitis B core antigen. Markers for HDV were found in 47 cases (1.7%). Antibodies to HDV were associated with Amerindian ethnic origin, a lower educational level, a history of acute viral hepatitis, a history of malaria, male sex, a history of tattooing, and older age. The most frequent HBV genotypes were A and F. This study showed a high prevalence of HBV and HDV in the western Brazilian Amazon, as well as the predominance of HBV genotypes A and F.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1
Rizzetto M, Canese MG, Arico S, Crinelo O, Trepo C, Bonino F, Verme G, 1977. Immunofluorescence detection of a new antigen-antibody system (delta/anti-delta) associated to hepatitis B virus in liver and serum of HBsAg carriers. Gut 18 :997–1003.
-
2
Gaeta GB, Stroffolini T, Chiaramonte M, Ascione T, Stornaiuolo G, Lobello S, Sagnelli E, Brunetto MR, Rizzeto M, 2003. Chronic hepatitis D: a vanishing disease? An Italian multicenter study. Hepatology 32 :824–827.
-
3
Bensabath G, Hadler SC, Soares MC, Fields H, Dias LB, Popper H, Maynard JE, 1987. Hepatitis delta virus infection and Labrea hepatitis. Prevalence and role in fulminant hepatitis in the Amazon Basin. JAMA 258 :479–483.
-
4
Bensabath G, Dias LB, 1983. Hepatite de Lábrea e outras hepatites em Sena Madureira, Acre e Boca do Acre, Amazonas, Brasil. Rev Inst Med Trop Sao Paulo 25 :182–194.
-
5
Andrade ZA, Lesbordes JL, Ravisse P, Parana R, Prata A, Barberino JS, Trepo C, 1992. Fulminant hepatitis with microvesicular steatosis (a histologic comparison of cases occurring in Brazil—Labrea hepatitis—and in central Africa—Bangui hepatitis). Rev Soc Bras Med Trop. 25 :155–160.
-
6
Lesbordes JL, Ravisse P, Georges AJ, Chevallier P, Pichoud C, Vitvitski L, Trepo C, 1987. Studies on the role of HDV in an outbreak of fulminant hepatitis in Bangui (Central African Republic). Prog Clin Biol Res 234 :451–459.
-
7
Kaneko S, Feinstone SM, Miller RH, 1989. Rapid and sensitive method for the detection of serum hepatitis B virus DNA using the polymerase chain reaction technique. J Clin Microbiol 27 :1930–1933.
-
8
Sitnik R, Pinho JR, Bertolini DA, Bernardini AP, da Silva LC, Carrilho FJ, 2004. Hepatitis B virus genotypes and precore and core mutants in Brazilian patients. J Clin Microbiol 42 :2455–2460.
-
9
Sanger F, Nicklen S, Coulson AR, 1992. DNA sequencing with chain-terminating inhibitors. Proc Nat Acad Sci USA 74 :5463–5467.
-
10
Erhardt A, Knuth R, Sagir A, Kirschberg O, Heintges T, Haussinger D, 2003. Socioepidemiological data on hepatitis delta in a German university clinic: increase in patients from Eastern Europe and the former Soviet Union. Z Gastroenterol 41 :523–526.
-
11
Braga WS, Brasil LM, de Souza RA, Castilho Mda C, da Fonseca JC, 2001. Ocorrencia da infecção pelo vírus da hepatite B (VHB) e delta (VHD) em sete grupos indígenas do Estado do Amazonas. Rev Soc Bras Med Trop 34 :349–355.
-
12
de Paula VS, Arruda ME, Vitral CL, Gaspar AM, 2001. Seroprevalence of viral hepatitis in riverine communities from the Western region of the Brazilian Amazon Basin. Mem Inst Oswaldo Cruz 96 :1123–1128.
-
13
Ribeiro LC, Souto FJ, 2000. Hepatite delta no estado de Mato Grosso: apresentação de cinco casos. Rev Soc Bras Med Trop 33 :599–602.
-
14
Manock SR, Kelley PM, Hyams KC, Douce R, Smalligan RD, Watts DM, Sharp TW, Casey JL, Gerin JL, Engle R, Alava-Alprecht A, Martinez CM, Bravo NB, Guevara AG, Russell KL, Mendoza W, Vimos C, 2000. An outbreak of fulminant hepatitis delta in the Waorani, an indigenous people of the Amazon basin of Ecuador. Am J Trop Med Hyg 63 :209–213.
-
15
Nakano T, Shapiro CN, Hadler SC, Casey JL, Mizokami M, Orito E, Robertson BH, 2001. Characterization of hepatitis D virus genotype III among Yucpa Indians in Venezuela. J Gen Virol 82 :2183–2189.
-
16
Casey JL, Brown TL, Colan EJ, Wignall FS, Gerin JL, 1993. A genotype of hepatitis D virus that occurs in northern South America. Proc Natl Acad Sci USA 90 :9016–9020.
-
17
Quintero A, Uzcategui N, Loureiro CL, Villegas L, Illarramendi X, Guevara ME, Ludert JE, Blitz L, Liprandi F, Pujol FH, 2001. Hepatitis delta virus genotypes III and I circulate associated with hepatitis B virus genotype F in Venezuela. J Med Virol 64 :356–359.
-
18
Blitz L, Pujol FH, Swenson PD, Porto L, Atencio R, Araujo M, Costa L, Monsalve DC, Torres JR, Fields HA, Lambert S, van Geyt C, Norder H, Magnius LO, Echevarria JM, Stuyver L, 1998. Antigenic diversity of hepatitis B virus strains of genotype F in Amerindians and other population groups from Venezuela. J Clin Microbiol 36 :648–651.
-
19
Magnius LO, Norder H, 1995. Subtypes, genotypes and molecular epidemiology of hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology 38 :24–34.
-
20
Chen YC, Sheen IS, Chu CM, Liaw YF, 2002. Prognosis following spontaneous HbsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology 123 :1084–1089.
-
21
Chulanov VP, Shipulin GA, Schaefer S, Gerlich WH, 2003. Kinetics of HBV DNA and HBsAg in acute hepatitis B patients with and without coinfection by other hepatitis viruses. J Med Virol 69 :313–323.
-
22
Fonseca JC, 2002. Hepatitis D. Rev Soc Bras Med Trop 35 :181–190.
-
23
Cheng Q, Jayan GC, Casey JL, 2003. Differential inhibition of RNA editing in hepatitis delta virus genotype III by the short and long forms of hepatitis delta antigen. J Virol 77 :7786–7795.
-
24
Ghuman HK, Kaur S, 1995. Delta-hepatitis. Indian J Pediatr 62 :691–693.
-
25
Rizzetto M, 1990. Hepatitis delta: the virus and disease. J Hepatol 11 :S145–S148.
-
26
Parana R, Lyra L, Trepo C, 1999. Intravenous vitamin complexes used in sporting activities and transmission of HCV in Brazil. Am J Gastroenterol 94 :857–858.
-
27
Parana R, Vitvitski L, Andrade Z, Trepo C, Cotrim H, Bertillon P, Silva F, Silva L, de Oliveira IR, Lyra L, 1999. Acute sporadic non A, non B hepatitis in northeastern Brazil: etiology and natural history. Hepatology 30 :289–293.
-
28
Costa E, 1932. Hepatite na Região do Boca do Acre. Gaz Med Bahia 3 :148–175.
-
29
Lesbordes JL, Ravisse P, Georges AJ, Beuzit Y, Ave P, Enamra D, Meunier DM, Georges MC, Gonzalez JP, Chevalier P, Trepo C, 1987. Le role du virus delta dans les hepatites fulminantes en Afrique Centrale. Ann Med Interne (Paris) 138 :199–201.
-
30
Casey JL, Niro GA, Engle RE, Vega A, Gomez H, McCarthy M, Watts DM, Hyams KC, Gerin JL, 1996. Hepatitis B virus (HBV)/hepatitis D. virus (HDV) coinfection in outbreaks of acute hepatitis in the Peruvian Amazon basin: the roles of HDV genotype III and HBV genotype F. J Infect Dis 174 :920–926.
-
31
Langon T, Fillon S, Pichoud C, Hantz O, Trepo C, Kay A, 1998. Analysis of a hepatitis delta virus isolate from the Central African Republic. Res Virol 149 :171–185.
-
32
Tang JR, Hantz O, Vitvitski L, Lamelin JP, Parana R, Cova L, Lesbordes JL, Trepo C, 1993. Discovery of a novel point mutation changing the HDAg expression of a hepatitis delta virus isolate from Central African Republic. J Gen Virol 74 :1827–1835.
-
33
Parana R, Gerard F, Lesbordes JL, Pichoud C, Vitvitski L, Lyra LG, Trepo C, 1995. Serial transmission of spongiocytic hepatitis to woodchucks (a possible association with a specific delta strain). J. Hepatol 22 :468–473.
-
34
Zhang YY, Tsega E, Hansson BG, 1996. Phylogenetic analysis of hepatitis D viruses indicating a new genotype I subgroup among African isolates. J Clin Microbiol 34 :3023–3030.
-
35
Radjef N, Ivaniushina V, Anais P, Trinchet J, Deny P, 2001. Hepatitis D virus (HDV) genome analysis from Africa suggest the existence of more than three worldwide HDV genotypes. J Hepatol 34 (Suppl 1):120.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 153 | 72 | 13 |
| Full Text Views | 415 | 12 | 2 |
| PDF Downloads | 160 | 14 | 2 |