Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1
World Health Organization, 2002. Dengue and dengue hemorrhagic fever. Fact sheet no. 117. Available at: http://www.who.int/mediacentre/factsheets/fs117/en/print.html
-
2
Halstead SB, 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239 :476–481.
-
3
Kliks SC, Nisalak A, Brandt WE, Wahl L, Burke DS, 1989. Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg 40 :444–451.
-
4
Thein S, Aung MM, Shwe TN, Aye M, Zaw A, Aye K, Aye KM, Aaskov J, 1997. Risk factors in dengue shock syndrome. Am J Trop Med Hyg 56 :566–572.
-
5
Barnes WJ, Rosen L, 1974. Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island. Am J Trop Med Hyg 23 :495–506.
-
6
Scott RM, Nimmannitya S, Bancroft WH, Mansuwan P, 1976. Shock syndrome in primary dengue infections. Am J Trop Med Hyg 25 :866–874.
-
7
Chungue E, Deubel V, Cassar O, Laille M, Martin PMV, 1993. Molecular epidemiology of dengue 3 viruses and genetic relatedness among dengue 3 strains isolated from patients with mild or severe form of dengue fever in French Polynesia. J Gen Virol 74 :2765–2770.
-
8
Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, Meas MT, Nogueira RH, Rosa AT, 1997. Origins of dengue type 2 viruses associated with increased pathogenecity in the Americas. Virology 230 :244–251.
-
9
Gubler DG, Suharyano W, Lubis I, Eram S, Gunarso S, 1981. Epidemic dengue 3 in Central Java, associated with low viremia in man. Am J Trop Med Hyg 30 :1094–1099.
-
10
Leitmeyer KC, Vaughn DW, Watts DM, Salas R, Villalobos de Chacon I, Ramos C, Rico-Hesse R, 1999. Dengue virus structural differences that correlate with pathogenesis. J Virol 73 :4738–4747.
-
11
Pandey BD, Igarashi A, 2000. Severity-related molecular differences among nineteen strains of dengue type 2 viruses. Microbiol Immunol 44 :179–188.
-
12
Rico-Hesse R, 1990. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology 174 :479–493.
-
13
Lewis JA, Chang G, Lanciotti RS, Kinney RM, Mayer LW, Trent DW, 1993. Phylogenetic relationships of dengue 2 viruses. Virology 197 :216–224.
-
14
Lanciotti RS, Lewis JG, Gubler DJ, Trent DW, 1994. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol 75 :65–75.
-
15
Chungue E, Cassar O, Drouet MT, Guzman MG, Laile M, Rosen L, Deubel V, 1995. Molecular epidemiology of dengue-1 and dengue-4 viruses. J Gen Virol 76 :1877–1884.
-
16
Lanciotti RS, Gubler DJ, Trent DW, 1997. Molecular evolution and phylogeny of dengue 4 viruses. J Gen Virol 78 :2279–2286.
-
17
Twiddy SS, Farrar JJ, Nguyen VC, Wills B, Gould EA, Gritsun T, Lloyd G, Holmes EC, 2002. Phylogenetic relationships and differential selection pressures among genotypes of dengue 2 virus. Virology 298 :63–72.
-
18
Venzon EL, Rudnick A, Marchette NJ, Fable AE, Dukellis E, 1972. The greater Manila dengue hemorrhagic fever epidemic of 1966. J Phil Med Assoc 48 :297–313.
-
19
Hayes CG, Manaloto CR, Gonzales A, Ranoa CP, 1988. Dengue infections in the Philippines: clinical and virologic findings in 517 hospitalized patients. Am J Trop Med Hyg 39 :110–116.
-
20
Quintos FN, Lim LE, Juliano L, Reyes A, Lacson P, 1954. Hemorrhagic fever observed among children in the Philippines. Phil J Ped 3 :1–19.
-
21
Tayag EA, 1998. The dengue epidemic of 1998 in the Philippines. Den Bull 22. World Health Organization Regional Office for South-East Asia. Available at: http://w3.whosea.org/en/Section10/Section332/Section520_2421.htm.
-
22
Matias RR, 2003. A historical review of dengue virus research in the Philippines. St. Luke’s J Med 1 :3–8.
-
23
Morita K, Tanaka M, Igarashi A, 1991. Rapid identification of dengue virus serotypes by using polymerase chain reaction. J Clin Mic 29 :2107–2110.
-
24
Igarashi A, Mohamed H, Yusof A, Sinniah M, Tanaka H, 1995. Production of type 2 dengue (D2) monoclonal antibody and cell culture derived D2 antigen for use in dengue IgM capture ELISA. Trop Med 37 :165–173.
-
25
Irie K, Mohan PM, Sasaguri Y, Putnak R, Padmanabhan R, 1989. Sequence analysis of cloned dengue virus type 2 genome (New Guinea C strain). Gene 75 :197–211.
-
26
Wang E, Ni H, Xu R, Barrett ADT, Watowich SJ, Gubler DJ, Weaver SC, 2000. Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. J Virol 74 :3227–3234.
-
27
Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG, 1997. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 24 :4876–4882.
-
28
Swofford DL, 1998. PAUP* 4.0 – Phylogenetic analysis using parsimony (*and other methods) 4.0b8. Sinauer Associates, Sutherland, MA.
-
29
ter Meulen J, Grau M, Lenz O, Emmerich P, Schmidtz H, Oh F, Jaspert R, Niedrig M, 2000. Isolation and partial characterization of dengue virus type 2 and 4 strains from dengue fever and dengue haemorrhagic fever patients from Mindanao, Republic of the Philippines. Trop Med Int Health 5 :325–329.
-
30
Tokuda A, Sugito K, Tabeta H, Takasaki T, Yamada K, Kurane I, 2002. 3 dengue fever cases infected during a group tour to the Philippines. Kansenshogaku Zasshi 76 :953–957.
-
31
Dash PK, Parida MM, Saxena P, Kumar M, Rai A, Pasha ST, Jana AM, 2004. Emergence and continued circulation of dengue 2 (genotype IV) virus strains in northern India. J Med Virol 74 :314–322.
-
32
Foster JE, Bennett SN, Vaughan H, Vorndam V, McMillan WO, Carrington CV, 2003. Molecular evolution and phylogeny of dengue type 4 virus in the Caribbean. Virol 306 :126–134.
-
33
Singh UB, Maitra A, Broor S, Rai A, Pasha ST, Seth P, 1999. Partial nucleotide sequencing and molecular evolution of epidemic causing Dengue 2 strains. J Inf Dis 180 :954–965.
-
34
Trent DW, Grant JA, Rosen L, Monath TP, 1983. Genetic variation among dengue 2 viruses of different geographic origin. Virology 128 :271–284.
-
35
Uzcategui NY, Camacho D, Comach G, Cuello de Uzcategui R, Holmes EC, Gould EA, 2001. Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombination. J Gen Virol 82 :2945–2953.
-
36
Gubler DJ, Nalim S, Tan R, Saipan H, Sulianti SJ, 1979. Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti. Am J Trop Med Hyg 45 :644–651.
-
37
Rosen L, Roseboom LE, Gubler DJ, Lien JC, Chaniotis BN, 1985. Comparative susceptibility of mosquito species and strains to oral and parenteral infection with dengue and Japanese encephalitis viruses. Am J Trop Med Hyg 34 :603–615.
-
38
Armstrong PM, Rico-Hesse R, 2003. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. Am J Trop Med Hyg 68 :539–544.
-
39
Morens DM, Marchette NJ, Chu MC, Halstead SB, 1991. Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild disease. Am J Trop Med Hyg 45 :644–651.
-
40
Wu SJ, Grouard-Vogel G, Mascola JR, Brachtel E, Putvana R, Louder MK, Filgueira L, Marovich MA, Wong HK, Blauvelt A, Murphy GS, Robb ML, Innes BL, Birx DL, Hayes CG, Frankel SS, 2000. Human skin Langerhans cells are targets of dengue virus infection. Nat Med 6 :816–820.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 24 | 24 | 4 |
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MOLECULAR EPIDEMIOLOGY OF DENGUE 2 VIRUSES IN THE PHILIPPINES: GENOTYPE SHIFT AND LOCAL EVOLUTION
LEONORA T. D. SALDA
LEONORA T. D. SALDA
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
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MARIA D. C. PARQUET
MARIA D. C. PARQUET
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
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RONALD R. MATIAS
RONALD R. MATIAS
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
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FILIPINAS F. NATIVIDAD
FILIPINAS F. NATIVIDAD
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
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NOBOYUKI KOBAYASHI
NOBOYUKI KOBAYASHI
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
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KOUICHI MORITA
KOUICHI MORITA
Department of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki City, Japan; Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, Philippines
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The pre-membrane (prM) and envelope (E) genes of 41 viruses isolated from dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) patients from 1995 to 2002 were sequenced to determine the genetic variability of dengue 2 (DENV 2) viruses in the Philippines. The envelope sequence data were compared with a global sample of DENV 2 obtained from GenBank. Phylogenetic analysis revealed that two distinct genotypes, Asian 2 and Cosmopolitan, are currently circulating locally, each with the potential to cause severe hemorrhagic disease. After the initial isolation in 1998, the Cosmopolitan genotype has gradually and effectively replaced Asian genotype 2 in the Philippines. Members of this genotype were closely related to viruses from Australia, Singapore, and Thailand.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
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-
1
World Health Organization, 2002. Dengue and dengue hemorrhagic fever. Fact sheet no. 117. Available at: http://www.who.int/mediacentre/factsheets/fs117/en/print.html
-
2
Halstead SB, 1988. Pathogenesis of dengue: challenges to molecular biology. Science 239 :476–481.
-
3
Kliks SC, Nisalak A, Brandt WE, Wahl L, Burke DS, 1989. Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. Am J Trop Med Hyg 40 :444–451.
-
4
Thein S, Aung MM, Shwe TN, Aye M, Zaw A, Aye K, Aye KM, Aaskov J, 1997. Risk factors in dengue shock syndrome. Am J Trop Med Hyg 56 :566–572.
-
5
Barnes WJ, Rosen L, 1974. Fatal hemorrhagic disease and shock associated with primary dengue infection on a Pacific island. Am J Trop Med Hyg 23 :495–506.
-
6
Scott RM, Nimmannitya S, Bancroft WH, Mansuwan P, 1976. Shock syndrome in primary dengue infections. Am J Trop Med Hyg 25 :866–874.
-
7
Chungue E, Deubel V, Cassar O, Laille M, Martin PMV, 1993. Molecular epidemiology of dengue 3 viruses and genetic relatedness among dengue 3 strains isolated from patients with mild or severe form of dengue fever in French Polynesia. J Gen Virol 74 :2765–2770.
-
8
Rico-Hesse R, Harrison LM, Salas RA, Tovar D, Nisalak A, Ramos C, Boshell J, Meas MT, Nogueira RH, Rosa AT, 1997. Origins of dengue type 2 viruses associated with increased pathogenecity in the Americas. Virology 230 :244–251.
-
9
Gubler DG, Suharyano W, Lubis I, Eram S, Gunarso S, 1981. Epidemic dengue 3 in Central Java, associated with low viremia in man. Am J Trop Med Hyg 30 :1094–1099.
-
10
Leitmeyer KC, Vaughn DW, Watts DM, Salas R, Villalobos de Chacon I, Ramos C, Rico-Hesse R, 1999. Dengue virus structural differences that correlate with pathogenesis. J Virol 73 :4738–4747.
-
11
Pandey BD, Igarashi A, 2000. Severity-related molecular differences among nineteen strains of dengue type 2 viruses. Microbiol Immunol 44 :179–188.
-
12
Rico-Hesse R, 1990. Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology 174 :479–493.
-
13
Lewis JA, Chang G, Lanciotti RS, Kinney RM, Mayer LW, Trent DW, 1993. Phylogenetic relationships of dengue 2 viruses. Virology 197 :216–224.
-
14
Lanciotti RS, Lewis JG, Gubler DJ, Trent DW, 1994. Molecular evolution and epidemiology of dengue-3 viruses. J Gen Virol 75 :65–75.
-
15
Chungue E, Cassar O, Drouet MT, Guzman MG, Laile M, Rosen L, Deubel V, 1995. Molecular epidemiology of dengue-1 and dengue-4 viruses. J Gen Virol 76 :1877–1884.
-
16
Lanciotti RS, Gubler DJ, Trent DW, 1997. Molecular evolution and phylogeny of dengue 4 viruses. J Gen Virol 78 :2279–2286.
-
17
Twiddy SS, Farrar JJ, Nguyen VC, Wills B, Gould EA, Gritsun T, Lloyd G, Holmes EC, 2002. Phylogenetic relationships and differential selection pressures among genotypes of dengue 2 virus. Virology 298 :63–72.
-
18
Venzon EL, Rudnick A, Marchette NJ, Fable AE, Dukellis E, 1972. The greater Manila dengue hemorrhagic fever epidemic of 1966. J Phil Med Assoc 48 :297–313.
-
19
Hayes CG, Manaloto CR, Gonzales A, Ranoa CP, 1988. Dengue infections in the Philippines: clinical and virologic findings in 517 hospitalized patients. Am J Trop Med Hyg 39 :110–116.
-
20
Quintos FN, Lim LE, Juliano L, Reyes A, Lacson P, 1954. Hemorrhagic fever observed among children in the Philippines. Phil J Ped 3 :1–19.
-
21
Tayag EA, 1998. The dengue epidemic of 1998 in the Philippines. Den Bull 22. World Health Organization Regional Office for South-East Asia. Available at: http://w3.whosea.org/en/Section10/Section332/Section520_2421.htm.
-
22
Matias RR, 2003. A historical review of dengue virus research in the Philippines. St. Luke’s J Med 1 :3–8.
-
23
Morita K, Tanaka M, Igarashi A, 1991. Rapid identification of dengue virus serotypes by using polymerase chain reaction. J Clin Mic 29 :2107–2110.
-
24
Igarashi A, Mohamed H, Yusof A, Sinniah M, Tanaka H, 1995. Production of type 2 dengue (D2) monoclonal antibody and cell culture derived D2 antigen for use in dengue IgM capture ELISA. Trop Med 37 :165–173.
-
25
Irie K, Mohan PM, Sasaguri Y, Putnak R, Padmanabhan R, 1989. Sequence analysis of cloned dengue virus type 2 genome (New Guinea C strain). Gene 75 :197–211.
-
26
Wang E, Ni H, Xu R, Barrett ADT, Watowich SJ, Gubler DJ, Weaver SC, 2000. Evolutionary relationships of endemic/epidemic and sylvatic dengue viruses. J Virol 74 :3227–3234.
-
27
Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG, 1997. The ClustalX windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res 24 :4876–4882.
-
28
Swofford DL, 1998. PAUP* 4.0 – Phylogenetic analysis using parsimony (*and other methods) 4.0b8. Sinauer Associates, Sutherland, MA.
-
29
ter Meulen J, Grau M, Lenz O, Emmerich P, Schmidtz H, Oh F, Jaspert R, Niedrig M, 2000. Isolation and partial characterization of dengue virus type 2 and 4 strains from dengue fever and dengue haemorrhagic fever patients from Mindanao, Republic of the Philippines. Trop Med Int Health 5 :325–329.
-
30
Tokuda A, Sugito K, Tabeta H, Takasaki T, Yamada K, Kurane I, 2002. 3 dengue fever cases infected during a group tour to the Philippines. Kansenshogaku Zasshi 76 :953–957.
-
31
Dash PK, Parida MM, Saxena P, Kumar M, Rai A, Pasha ST, Jana AM, 2004. Emergence and continued circulation of dengue 2 (genotype IV) virus strains in northern India. J Med Virol 74 :314–322.
-
32
Foster JE, Bennett SN, Vaughan H, Vorndam V, McMillan WO, Carrington CV, 2003. Molecular evolution and phylogeny of dengue type 4 virus in the Caribbean. Virol 306 :126–134.
-
33
Singh UB, Maitra A, Broor S, Rai A, Pasha ST, Seth P, 1999. Partial nucleotide sequencing and molecular evolution of epidemic causing Dengue 2 strains. J Inf Dis 180 :954–965.
-
34
Trent DW, Grant JA, Rosen L, Monath TP, 1983. Genetic variation among dengue 2 viruses of different geographic origin. Virology 128 :271–284.
-
35
Uzcategui NY, Camacho D, Comach G, Cuello de Uzcategui R, Holmes EC, Gould EA, 2001. Molecular epidemiology of dengue type 2 virus in Venezuela: evidence for in situ virus evolution and recombination. J Gen Virol 82 :2945–2953.
-
36
Gubler DJ, Nalim S, Tan R, Saipan H, Sulianti SJ, 1979. Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti. Am J Trop Med Hyg 45 :644–651.
-
37
Rosen L, Roseboom LE, Gubler DJ, Lien JC, Chaniotis BN, 1985. Comparative susceptibility of mosquito species and strains to oral and parenteral infection with dengue and Japanese encephalitis viruses. Am J Trop Med Hyg 34 :603–615.
-
38
Armstrong PM, Rico-Hesse R, 2003. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. Am J Trop Med Hyg 68 :539–544.
-
39
Morens DM, Marchette NJ, Chu MC, Halstead SB, 1991. Growth of dengue type 2 virus isolates in human peripheral blood leukocytes correlates with severe and mild disease. Am J Trop Med Hyg 45 :644–651.
-
40
Wu SJ, Grouard-Vogel G, Mascola JR, Brachtel E, Putvana R, Louder MK, Filgueira L, Marovich MA, Wong HK, Blauvelt A, Murphy GS, Robb ML, Innes BL, Birx DL, Hayes CG, Frankel SS, 2000. Human skin Langerhans cells are targets of dengue virus infection. Nat Med 6 :816–820.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 24 | 24 | 4 |
| Full Text Views | 502 | 124 | 0 |
| PDF Downloads | 275 | 47 | 0 |