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5-DAY NONOBSERVED ARTESUNATE MONOTHERAPY FOR TREATING UNCOMPLICATED FALCIPARUM MALARIA IN YOUNG GABONESE CHILDREN

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  • 1 Medical Research Unit, Albert Schweitzer Hospital Lambaréné, Gabon; Institute of Tropical Medicine, Department of Parasitology, University of Tübingen, Tübingen, Germany

Despite different recommendations from WHO and national authorities, artesunate monotherapy is increasingly used for treating African children with malaria. A 5-day course of oral artesunate (first day: 4 mg/kg body weight, observed intake; and 2 mg/kg body weight on the following days with nonobserved drug intake) yielded a PCR-corrected Day 28 cure rate of 90% (45 of 50 patients; CI 78–97%) in Gabonese children aged between 2 and 18 months. Artesunate was well tolerated, and no severe adverse events were reported.

Author Notes

Reprint requests: Martin P. Grobusch, University of the Witwatersrand, Infectious Diseases Unit, Johannesburg, South Africa, Telephone: +2711 489 8537; Fax: +2711 489 8530, E-mail: grobuschmp@pathology.wits.ac.za.
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