• 1

    Igarashi A, 1997. Impact of dengue virus infection and its control. FEMS Immunol Med Microbiol 18 :291–300.

  • 2

    Guzman MG, Kouri G, 2002. Dengue: an update. Lancet Infect Dis 2 :33–42.

  • 3

    Hammon WM, Rudnick A, Sather GE, 1960. Viruses associated with epidemic hemorrhagic fevers of the Philippines and Thailand. Science 131 :1102–1103.

    • Search Google Scholar
    • Export Citation
  • 4

    Venzon EI, Rudnick A, Marchette NJ, Fabie AE, Dukellis E, 1972. The greater Manila dengue hemorrhagic fever epidemic of 1966. J Philippine Med Assoc 48 :297–313.

    • Search Google Scholar
    • Export Citation
  • 5

    Dizon JJ, 1978. The occurrence of dengue haemorrhagic fever in the Philippines. Asian J Infect Dis 2 :15–17.

  • 6

    Hayes CG, Corazon RM, Gonzales A, Ranoa CP, 1988. Dengue infections in the Philippines: clinical and virological findings in 517 hospitalized patients. Am J Trop Med Hyg. 39 :110–116.

    • Search Google Scholar
    • Export Citation
  • 7

    Songco RS, Hayes CG, Leus CD, Manaloto COR, 1987. Dengue fever/dengue haemorrhagic fever in Filipino children: clinical experience during the 1983–1984 epidemic. Southeast Asian J Trop Med Public Health 18 :284–290.

    • Search Google Scholar
    • Export Citation
  • 8

    Nimmannitya S, 1987. Clinical spectrum and management of dengue haemorrhagic fever. Southeast Asian J Trop Med Public Health 18 :329–397.

    • Search Google Scholar
    • Export Citation
  • 9

    Kalayanarooj S, Vaughn DW, Nimmannitya S, Gree S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachueke S, Kiatpolpoj S, Innis BL, Rothman AL, Bisalak A, Ennis FA, 1997. Early clinical and laboratory indicator of acute dengue illness. J Infect Dis 176 :313–321.

    • Search Google Scholar
    • Export Citation
  • 10

    Kabra SK, Jain Y, Pandey RM, Madhulika, Sinhai T, Tripathi P, Brooe S, Seth P, Seth V, 1999. Dengue haemorrhagic fever in children in the 1996 Delhi epidemic. Trans R Soc Trop Med Hyg. 93 :294–298.

    • Search Google Scholar
    • Export Citation
  • 11

    Vaughn DW, Green S, Kalayanarooj S, Innis BL, Nimmannitya S, Suntayakorn S, Rothman AL, Ennis FA, Nisalak A, 1997. Dengue in the early febrile phase: viremia and antibody responses. J Infect Dis 176 :322–330.

    • Search Google Scholar
    • Export Citation
  • 12

    Bundo K, Igarashi A, 1985. Antibody-captured ELISA for detection of immunoglobulin M antibodies in sera from Japanese encephalitis and dengue hemorrhagic fever patients. J Virol Methods 11 :15–22.

    • Search Google Scholar
    • Export Citation
  • 13

    Morita K, Tanaka M, Igarashi A, 1991. Rapid identification of dengue virus serotypes by using polymerase chain reaction. J Clin Microbiol 29 :2107–2110.

    • Search Google Scholar
    • Export Citation
  • 14

    Rigau-Perez JG, Clark GG, Gubler DJ, Reiter P, Sanders EJ, Vorndam AV, 1998. Dengue and dengue haemorrhagic fever. Lancet. 352 :971–977.

    • Search Google Scholar
    • Export Citation
  • 15

    Baalmaseda A, Sandoval E, Perez L, Gutierrez CM, Harris E, 1999. Application of molecular typing techniques in the 1998 dengue epidemic in Nicaragua. Am J Trop Med Hyg. 61 :893–897.

    • Search Google Scholar
    • Export Citation
  • 16

    Raengsakulrach B, Nisalak A, Maneekarn N, Yenchitsomanus P, Limsomwong C, Jairungsri A, Thirawuth V, Green S, Kalayanarooj S, Suntayakorn S, Sittisombut N, Malasit P, Vaughn DW, 2002. Comparisons of four reverse transcription-polymerase chain reaction procedures for the detection of dengue virus in clinical specimens. J Virol Methods. 105 :219–231.

    • Search Google Scholar
    • Export Citation
  • 17

    World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition Geneva: World Health Organization.

  • 18

    Nishiyama T, Matsukawa T, Hanaoka K, 2000. Is protease inhibitor a choice for the treatment of pre- or mild disseminated intravascular coagulation? Crit Care Med 28 :1419.

    • Search Google Scholar
    • Export Citation
  • 19

    Ogden CL, Kaczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, Grummer-Strawn LM, Curtin LR, Roche AF, Jhonson CL, 2002. Centers for Disease Control and Prevention 2000 Growth Charts for the United States: improvements to the 1977 National Center for Health Statistics Version. Pediatrics 109 :45–60.

    • Search Google Scholar
    • Export Citation
  • 20

    Setiawan MW, Samsi TK, Wulur H, Sugianto D, Pool TN, 1998. Epigastric pain and sonographic assessment of the pancreas in dengue hemorrhagic fever. J Clin Ultrasound 26 :257–259.

    • Search Google Scholar
    • Export Citation
  • 21

    Wang J, Tseng C, Lee C, Cheng K, 1990. Clinical and upper gastroendoscopic features of patients with dengue virus infection. J Gastroenterol Hepatol 5 :664–668.

    • Search Google Scholar
    • Export Citation
  • 22

    Boonpucknavig S, Lohachitranond C, Nimmanitya S, 1979. The pattern and nature of the lymphocyte population response in dengue hemorrhagic fever. Am J Trop Med Hyg 28 :885–889.

    • Search Google Scholar
    • Export Citation
  • 23

    Suvatte V, Longsaman M, 1979. Diagnostic value of buffy coat preparation in dengue hemorrhagic fever. Southeast Asian J Trop Med Public Health 10 :7–12.

    • Search Google Scholar
    • Export Citation
  • 24

    Thisyakorn U, Nimmannitya S, Ninganond V, Soogarun S, 1984. Atypical lymphocytes in dengue hemorrhagic fever: it’s value in diagnosis. Southeast Asian J Trop Med Public Health 15 :32–36.

    • Search Google Scholar
    • Export Citation
  • 25

    Mitrakul C, Poshyachinda M, Futralul P, Sangkawibha N, Ahandrik S, 1977. Hemostatic and platelet kinetic studies in dengue hemorrhagic fever. Am J Trop Med Hyg. 26 :975–984.

    • Search Google Scholar
    • Export Citation
  • 26

    Srichaikul T, Nimmannitya S, Artchararit N, Sriasawakul T, Sungpeuk P, 1977. Fibrinogen metabolism and disseminated intravascular coagulation in dengue hemorrhagic fever. Am J Trop Med Hyg 26 :525–532.

    • Search Google Scholar
    • Export Citation
  • 27

    Huang YH, Liu CC, Wang ST, Lei HY, Liu HS, Lin YS, Wu HL, Yeh TM, 2001. Activation of coagulation and fibrinolysis during dengue virus infection. J Med Virol 63 :247–251.

    • Search Google Scholar
    • Export Citation
  • 28

    Wills B, Oraqui EE, Stephens AC, Daramola OA, Dung NM, Loan HT, Chau NV, Chambers M, Stepniewska K, Farrar JJ, Levin M, 2002. Coagulation abnormalities in dengue hemorrhagic fever: serial investigations in 167 Vietnamese children with dengue shock syndrome. Clin Infect Dis 35 :277–285.

    • Search Google Scholar
    • Export Citation
  • 29

    Krishnamurti C, Kalayanarooj S, Cutting MA, Peat RA, Rothwell SW, Reid TJ, Green S, Nisalak A, Endy TP, Vaughn DW, Nimmannitya S, Innis BL, 2001. Mechanisms of hemorrhage in dengue without circulatory collapse. Am J Trop Med Hyg 65 :840–847.

    • Search Google Scholar
    • Export Citation
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COMPARISON OF CLINICAL FEATURES AND HEMATOLOGIC ABNORMALITIES BETWEEN DENGUE FEVER AND DENGUE HEMORRHAGIC FEVER AMONG CHILDREN IN THE PHILIPPINES

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  • 1 Department of Pediatrics, and Research and Biotechnology Division, St. Luke’s Medical Center, Quezon City, The Philippines; Institute of Biology, University of the Philippines Diliman, Quezon City, The Philippines; Department of Internal Medicine and Virology, Institute of Tropical Medicine Nagasaki University, Nagasaki, Japan
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To demonstrate the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St. Luke’s Medical Center in Quezon City, between 1999 and 2001 in Metro Manila, and adjoining provinces the Philippines, with a laboratory-confirmed dengue virus infection were evaluated. One third of the patients had DHF, and most of these patients were without shock. Restlessness, epistaxis, and abdominal pain were more associated with DHF. The platelet count was significantly lower in the DHF group than in the DF group before and after defervescence. In the DHF patients, the hematocrit was significantly increased before defervescence, and decreased the day after due to administration of intravenous fluid. Coagulation abnormalities associated with most DHF patients were thrombocytopenia and an increased fibrinolysis, but not disseminated intravascular coagulation. We present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and consequently earlier appropriate treatment of dengue virus infections.

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