INFECTION BY HUMAN IMMUNODEFICIENCY VIRUS-1 IS NOT A RISK FACTOR FOR AMEBIASIS

PATRICIA MORÁN Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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FERNANDO RAMOS Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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MANUEL RAMIRO Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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OCTAVIO CURIEL Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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ENRIQUE GONZÁLEZ Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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ALICIA VALADEZ Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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ALEJANDRO GÓMEZ Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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GABRIELA GARCÍA Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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EMMA I. MELENDRO Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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CECILIA XIMÉNEZ Departamento de Medicina Experimental, Facultad de Medicina, UNAM, México, D.F.; Hospital Regional 1. de Octubre, ISSSTE, México, D.F.; Clínica Lomas Altas, México, D.F.; Coordinación de Investigación en Salud, IMSS, México, D.F.

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The purpose of this study was to determine whether HIV-1 infected patients in our community were more susceptible to Entamoeba histolytica and Entamoeba dispar infection than non-HIV-infected individuals. The prevalence and frequency of invasive amebiasis was determined in 203 HIV+/AIDS subjects and 140 close relatives or sexual partners, all of whom were HIV. Anti–E. histolytica antibodies (IgG, IgA) were assessed as indicators of E. histolytica invasive infection. Polymerase chain reaction (PCR) was used for the characterization of the Entamoeba species. The prevalence estimated with PCR data showed that E. histolytica infection was more common in the HIV+/AIDS group (25.32%), than in HIV contacts (18.46%). E. histolytica + E. dispar infection was more frequent in HIV+/AIDS patients (13.3%), than in HIV contacts (0.7%). E. histolytica and/or E. dispar infection was highly prevalent in HIV+/AIDS patients (34.1%) without evidence of recent or current invasive disease. Contacts of HIV+/AIDS patients who were infected with E. histolytica were asymptomatic cyst passers. Our results suggest that E. histolytica strains prevalent in the studied community appear to be of low pathogenic potential.

Author Notes

Reprint requests: Dr. Cecilia Ximénez, Depto. de Medicina Experimental, Facultad de Medicina, UNAM, Dr. Balmis 148, Col. Doctores, C.P. 06726, México D.F., México. Telephone: +5255-56-23-26-66, Fax: +5255-56-23-26-79, E-mail: cximenez@servidor.unam.mx.
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