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1
Trape JF, Pison G, Spiegel A, Enel C, 2002. Combating malaria in Africa. Trends Parasitol 18 :224–230.
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2
van Vugt M, Leonardi E, Phaipun L, Slight T, Thway K, McGready R, Brockman A, Villegas L, Looareesuwan S, White NJ, Nosten F, 2002. Treatment of uncomplicated multidrug resistant falciparum malaria with artesunate-atovaquone-proguanil. Clin Infect Dis 15 :1498–1504.
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3
Karbwang J, Davis T, Looareesuwan S, Molunto P, Bunnag D, White NJ, 1993. A comparison of the pharmacokinetic and pharmacodynamic properties of qunine and quinidine in healthy Thai males. Br J Pharmacol 35 :265–271.
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4
Nosten F, ter Kuile F, Luxemburger C, Woodrow C, Kyle D, Chongsuphajaisiddhi T, White NJ, 1993. Cardiac effects of antimalarial treatment with halofantrine. Lancet 341 :1054–1056.
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5
van Vugt M, Ezzet F, Nosten F, Gathmann I, Wilairatna P, Looareesuwan S, White NJ, 1999. No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine. Am J Trop Med Hyg 61 :964–967.
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6
ter Kuile F, Nosten F, Luxemburger C, Kyle D, Teja-Isavatharm P, Phaipun L, Price R, Chongsuphajaisiddhi T, White NJ, 1995. Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients. Bull World Health Organ 73 :631–642.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 417 | 376 | 34 |
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NO EVIDENCE OF CARDIOTOXICITY OF ATOVAQUONE-PROGUANIL ALONE OR IN COMBINATION WITH ARTESUNATE
RAVINDRA K. GUPTA
RAVINDRA K. GUPTA
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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MICHELE VAN VUGT
MICHELE VAN VUGT
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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LUCY PAIPHUN
LUCY PAIPHUN
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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THRA SLIGHT
THRA SLIGHT
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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SORNCHAI LOOAREESUWAN
SORNCHAI LOOAREESUWAN
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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NICHOLAS J. WHITE
NICHOLAS J. WHITE
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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FRANÇOIS NOSTEN
FRANÇOIS NOSTEN
Department of Infection, St. Thomas’ Hospital, London, United Kingdom; Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands; Shoklo Malaria Research Unit, Mae Sot, Thailand; Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, United Kingdom
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Combinations are set to become the mainstay in treatment and prophylaxis of malaria due to Plasmodium falciparum. Various antimalarials have been implicated in cardiotoxicity via prolongation of the QTc interval. Atovaquone-proguanil is an effective and increasingly popular antimalarial choice when used alone or with artesunate in areas of drug resistance. We report the results of an investigation carried out on the Thai-Burmese border in 42 patients randomized to receive either atovaquone-proguanil or atovaquone-proguanil-artesunate for three days. Electrocardiographic recordings were made at baseline and one hour after each dose. There was no statistically significant change in QTc interval between baseline and any subsequent readings in either treatment group or the cohort as a whole. We conclude that atovaquone-proguanil shows no evidence of cardiotoxicity either alone or when combined with artesunate.
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-
1
Trape JF, Pison G, Spiegel A, Enel C, 2002. Combating malaria in Africa. Trends Parasitol 18 :224–230.
-
2
van Vugt M, Leonardi E, Phaipun L, Slight T, Thway K, McGready R, Brockman A, Villegas L, Looareesuwan S, White NJ, Nosten F, 2002. Treatment of uncomplicated multidrug resistant falciparum malaria with artesunate-atovaquone-proguanil. Clin Infect Dis 15 :1498–1504.
-
3
Karbwang J, Davis T, Looareesuwan S, Molunto P, Bunnag D, White NJ, 1993. A comparison of the pharmacokinetic and pharmacodynamic properties of qunine and quinidine in healthy Thai males. Br J Pharmacol 35 :265–271.
-
4
Nosten F, ter Kuile F, Luxemburger C, Woodrow C, Kyle D, Chongsuphajaisiddhi T, White NJ, 1993. Cardiac effects of antimalarial treatment with halofantrine. Lancet 341 :1054–1056.
-
5
van Vugt M, Ezzet F, Nosten F, Gathmann I, Wilairatna P, Looareesuwan S, White NJ, 1999. No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine. Am J Trop Med Hyg 61 :964–967.
-
6
ter Kuile F, Nosten F, Luxemburger C, Kyle D, Teja-Isavatharm P, Phaipun L, Price R, Chongsuphajaisiddhi T, White NJ, 1995. Mefloquine treatment of acute falciparum malaria: a prospective study of non-serious adverse effects in 3673 patients. Bull World Health Organ 73 :631–642.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 417 | 376 | 34 |
| Full Text Views | 271 | 4 | 0 |
| PDF Downloads | 87 | 4 | 0 |