- INTRODUCTION
- MATERIALS AND METHODS
- RESULTS
- Characteristics of Buritis, Colina, and Ribeirinha.
- Relationship between years of residence in the endemic area and malaria history.
- Anti-PvRBP1 and anti-PvDBP-RII seroprevalence in three communities of Rondônia.
- Magnitude of IgG responses.
- Multivariate logistic regression analysis of total IgG antibody reactivity according to gender, age, and indices of malaria exposure.
- Seroprevalence and malaria exposure.
- IgG subclass distribution of anti-PvDBP-RII and anti-PvRBP1 antibodies.
- IgG subclass levels and months since last known malaria episode.
- DISCUSSION
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COMPARISON OF IgG REACTIVITIES TO PLASMODIUM VIVAX MEROZOITE INVASION ANTIGENS IN A BRAZILIAN AMAZON POPULATION
Naturally acquired antibody reactivity to two major Plasmodium vivax vaccine candidates was investigated in 294 donors from three malaria-endemic communities of Rondônia state, Brazil. Antibody recognition of recombinantly expressed antigens covering five different regions of P. vivax reticulocyte binding protein 1 (PvRBP1) and region II of P. vivax Duffy binding protein (PvDBP-RII) were compared. Positive IgG responses to these antigens were significantly related to the level of malaria exposure in terms of past infections and years of residence in the endemic area when corrected for age. The highest prevalence of anti-PvRBP1 total IgG antibodies corresponded to the amino acid regions denoted PvRBP1431-748 (41%) and PvRBP1733-1407 (47%). Approximately one-fifth of positively responding sera had titers of at least 1:1,600. Total IgG responses to PvDBP-RII were more prevalent (67%), of greater magnitude, and acquired more rapidly than those to individual PvRBP1 antigens. Responses to both PvRBP1 and PvDBP-RII were biased toward the cytophilic subclasses IgG1 and IgG3. These data provide the first insights on acquired antibody responses to PvRBP1 and a comparative view with PvDBP-RII that may prove valuable for understanding protective immune responses to these two vaccine candidates as they are evaluated as components of multitarget blood-stage vaccines.