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-
1
White NJ, Ho M, 1992. The pathophysiology of malaria. Adv Parasitol 31 :83–173.
-
2
Roberts DD, Sherwood JA, Spitalnik SL, Panton LJ, Howard RJ, Dixit VM, Frazier WA, Miller LH, Ginsburg V, 1985. Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature 318 :64–66.
-
3
Ockenhouse CF, Tandon NN, Magowan C, Jamieson GA, Chulay JD, 1989. Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor. Science 243 :1469–1471.
-
4
Berendt AR, Simmons DL, Tansey J, Newbold CI, Marsh K, 1989. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature 341 :57–59.
-
5
Ockenhouse CF, Tegoshi T, Maeno Y, Benjamin C, Ho M, Kan KE, Thway Y, Win K, Aikawa M, Lobb RR, 1992. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule1. J Exp Med 176 :1183–1189.
-
6
Treutiger CJ, Heddini A, Fernandez V, Muller WA, Wahlgren M, 1997. PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Nat Med 3 :1405–1408.
-
7
Hatabu T, Kawazu S, Aikawa M, Kano S, 2003. Binding of Plasmodium falciparum-infected erythrocytes to the membrane-bound form of Fractalkine/CX3CL1. Proc Natl Acad Sci USA 100 :15942–15946.
-
8
Udomsangpetch R, Reinhardt PH, Schollaardt T, Elliott JF, Kubes P, Ho M, 1997. Promiscuity of clinical Plasmodium falciparum isolates for multiple adhesion molecules under flow conditions. J Immunol 158 :4358–4364.
-
9
Yipp BG, Anand S, Schollaardt T, Patel KD, Looareesuwan S, Ho M, 2000. Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow. Blood 6 :2292–2298.
-
10
Ho M, Hickey MJ, Murray AG, Andonegui G, Kubes P, 2000. Visualization of Plasmodium falciparum-endothelium interactions in human microvasculature: mimicry of leukocyte recruitment. J Exp Med 192 :1205–1211.
-
11
Kubes P, 2002. The complexities of leukocyte recruitment. Semin Immunol 14 :65–72.
-
12
Abbitt KB, Nash GB, 2003. Rheological properties of the blood influencing selectin-mediated adhesion of flowing leukocytes. Am J Physiol Heart Circ Physiol 285 :H229–H240.
-
13
Kwiatkowski D, Hill AVS, Sambou I, Twumasi P, Castracane J, Manogue KR, Cermai A, Brewster DR, Greenwood BM, 1990. TNF concentration in fatal cerebral, non-fatal cerebral and uncomplicated Plasmodium falciparum malaria. Lancet 336 :1201–1204.
-
14
Day NPJ, Hien TT, Schollaardt T, Loc PP, Chuong LV, Chau TTH, Nguyen THM, Nguyen HP, Dinh XS, White NJ, Ho M, 1999. The prognostic and pathophysiological role of pro- and anti-inflammatory cytokines in severe malaria. J Infect Dis 180 :1288–1298.
-
15
McCormick CJ, Craig A, Roberts D, Newbold CI, Berendt AR, 1997. Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells. J Clin Invest 100 :2521–2529.
-
16
Frangos JA, Eskin SG, McIntire LV, Ives CL, 1985. Flow effects on prostacyclin production by cultured human endothelial cells. Science 227 :1477–1479.
-
17
Whitmore RL, 1968. Rheology of the circulation. Oxford: Pergamon Press, 79–96.
-
18
Dondorp AM, Angus BJ, Chotivanich K, Silamut K, Ruangveerayuth R, Hardeman MR, Kager PA, Vreeken J, White NJ, 1999. Red blood cell deformability as a predictor of anemia in severe falciparum malaria. Am J Trop Med Hyg 60 :733–737.
-
19
Dondorp AM, Nyanoti M, Kager PA, Mithwani S, Vreekem J, Marsh K, 2002. The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion. Trans R Soc Trop Med Hyg 96 :282–286.
-
20
Secomb TW, Hsu R, Pries AR, 1998. A model for red blood cell motion in glycocalyx lined capillaries. Am J Physiol 274 :1016–1022.
-
21
Osterloh K, Ewert U, Pries AR, 2002. Interaction of albumin with the endothelial cell surface. Am J Physiol Heart Circ Physiol 283 :H398–H405.
-
22
Kubes P, 1997. The role of shear forces in ischemia/reperfusion-induced neutrophil rolling and adhesion. J Leukoc Biol 62 :458–464.
-
23
Fan F-C, Chen RYZ, Schuessler GB, Chien S, 1980. Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog. Am J Physiol 238 :H545–H552.
-
24
Pries AR, Secomb TW, Gaehtgens P, 1995. Design principles of vascular beds. Circ Res 77 :1017–1025.
-
25
Dondorp AM, Angus BJ, Hardeman MR, Chotivanich KT, Silamut K, Ruangveerayuth R, Kager PA, White NJ, Vreeken J, 1997. Prognostic significance of reduced red blood cell deformability in severe falciparum malaria. Am J Trop Med Hyg 57 :507–511.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 261 | 231 | 9 |
| Full Text Views | 236 | 2 | 0 |
| PDF Downloads | 47 | 2 | 0 |
ATTENUATION OF CYTOADHERENCE OF PLASMODIUM FALCIPARUM TO MICROVASCULAR ENDOTHELIUM UNDER FLOW BY HEMODILUTION
CHRISTINE FLATT
CHRISTINE FLATT
Department of Microbiology and Infectious Diseases and Immunology Research Group, University of Calgary, Calgary, Alberta, Canada; Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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SHEONA MITCHELL
SHEONA MITCHELL
Department of Microbiology and Infectious Diseases and Immunology Research Group, University of Calgary, Calgary, Alberta, Canada; Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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BRYAN YIPP
BRYAN YIPP
Department of Microbiology and Infectious Diseases and Immunology Research Group, University of Calgary, Calgary, Alberta, Canada; Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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SORNCHAI LOOAREESUWAN
SORNCHAI LOOAREESUWAN
Department of Microbiology and Infectious Diseases and Immunology Research Group, University of Calgary, Calgary, Alberta, Canada; Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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MAY HO
MAY HO
Department of Microbiology and Infectious Diseases and Immunology Research Group, University of Calgary, Calgary, Alberta, Canada; Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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The cytoadherence of Plasmodium falciparum–infected erythrocytes (IRBCs) to endothelium is mediated by adhesion molecules within the physical constraints of a viscous fluid containing mostly erythrocytes. The volume fraction of erythrocytes (hematocrit) and their physical properties, such as deformability, are important properties of blood that affect cell recruitment to the vascular wall. In the present study, we examined the effect of hematocrit on IRBC rolling and adhesion on human microvascular endothelial cells in a flow chamber system in vitro. We found hematocrit to be a major determinant of IRBC/endothelial cell interactions. There was a 5-fold and 12-fold increase in IRBC rolling and adhesion, respectively, when hematocrit increased from 10% to 30%, as a result of changes in shear rate. Similar effects were seen in the presence of less deformable erythrocytes, serum proteins, and on endothelium stimulated with tumor necrosis factor-α. The results indicate that hemorheologic variations are an important determinant of the degree of cytoadherence.
Author Notes
ProCite
RefWorks
Reference Manager
BibTeX
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-
1
White NJ, Ho M, 1992. The pathophysiology of malaria. Adv Parasitol 31 :83–173.
-
2
Roberts DD, Sherwood JA, Spitalnik SL, Panton LJ, Howard RJ, Dixit VM, Frazier WA, Miller LH, Ginsburg V, 1985. Thrombospondin binds falciparum malaria parasitized erythrocytes and may mediate cytoadherence. Nature 318 :64–66.
-
3
Ockenhouse CF, Tandon NN, Magowan C, Jamieson GA, Chulay JD, 1989. Identification of a platelet membrane glycoprotein as a falciparum malaria sequestration receptor. Science 243 :1469–1471.
-
4
Berendt AR, Simmons DL, Tansey J, Newbold CI, Marsh K, 1989. Intercellular adhesion molecule-1 is an endothelial cell adhesion receptor for Plasmodium falciparum. Nature 341 :57–59.
-
5
Ockenhouse CF, Tegoshi T, Maeno Y, Benjamin C, Ho M, Kan KE, Thway Y, Win K, Aikawa M, Lobb RR, 1992. Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule1. J Exp Med 176 :1183–1189.
-
6
Treutiger CJ, Heddini A, Fernandez V, Muller WA, Wahlgren M, 1997. PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Nat Med 3 :1405–1408.
-
7
Hatabu T, Kawazu S, Aikawa M, Kano S, 2003. Binding of Plasmodium falciparum-infected erythrocytes to the membrane-bound form of Fractalkine/CX3CL1. Proc Natl Acad Sci USA 100 :15942–15946.
-
8
Udomsangpetch R, Reinhardt PH, Schollaardt T, Elliott JF, Kubes P, Ho M, 1997. Promiscuity of clinical Plasmodium falciparum isolates for multiple adhesion molecules under flow conditions. J Immunol 158 :4358–4364.
-
9
Yipp BG, Anand S, Schollaardt T, Patel KD, Looareesuwan S, Ho M, 2000. Synergism of multiple adhesion molecules in mediating cytoadherence of Plasmodium falciparum-infected erythrocytes to microvascular endothelial cells under flow. Blood 6 :2292–2298.
-
10
Ho M, Hickey MJ, Murray AG, Andonegui G, Kubes P, 2000. Visualization of Plasmodium falciparum-endothelium interactions in human microvasculature: mimicry of leukocyte recruitment. J Exp Med 192 :1205–1211.
-
11
Kubes P, 2002. The complexities of leukocyte recruitment. Semin Immunol 14 :65–72.
-
12
Abbitt KB, Nash GB, 2003. Rheological properties of the blood influencing selectin-mediated adhesion of flowing leukocytes. Am J Physiol Heart Circ Physiol 285 :H229–H240.
-
13
Kwiatkowski D, Hill AVS, Sambou I, Twumasi P, Castracane J, Manogue KR, Cermai A, Brewster DR, Greenwood BM, 1990. TNF concentration in fatal cerebral, non-fatal cerebral and uncomplicated Plasmodium falciparum malaria. Lancet 336 :1201–1204.
-
14
Day NPJ, Hien TT, Schollaardt T, Loc PP, Chuong LV, Chau TTH, Nguyen THM, Nguyen HP, Dinh XS, White NJ, Ho M, 1999. The prognostic and pathophysiological role of pro- and anti-inflammatory cytokines in severe malaria. J Infect Dis 180 :1288–1298.
-
15
McCormick CJ, Craig A, Roberts D, Newbold CI, Berendt AR, 1997. Intercellular adhesion molecule-1 and CD36 synergize to mediate adherence of Plasmodium falciparum-infected erythrocytes to cultured human microvascular endothelial cells. J Clin Invest 100 :2521–2529.
-
16
Frangos JA, Eskin SG, McIntire LV, Ives CL, 1985. Flow effects on prostacyclin production by cultured human endothelial cells. Science 227 :1477–1479.
-
17
Whitmore RL, 1968. Rheology of the circulation. Oxford: Pergamon Press, 79–96.
-
18
Dondorp AM, Angus BJ, Chotivanich K, Silamut K, Ruangveerayuth R, Hardeman MR, Kager PA, Vreeken J, White NJ, 1999. Red blood cell deformability as a predictor of anemia in severe falciparum malaria. Am J Trop Med Hyg 60 :733–737.
-
19
Dondorp AM, Nyanoti M, Kager PA, Mithwani S, Vreekem J, Marsh K, 2002. The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion. Trans R Soc Trop Med Hyg 96 :282–286.
-
20
Secomb TW, Hsu R, Pries AR, 1998. A model for red blood cell motion in glycocalyx lined capillaries. Am J Physiol 274 :1016–1022.
-
21
Osterloh K, Ewert U, Pries AR, 2002. Interaction of albumin with the endothelial cell surface. Am J Physiol Heart Circ Physiol 283 :H398–H405.
-
22
Kubes P, 1997. The role of shear forces in ischemia/reperfusion-induced neutrophil rolling and adhesion. J Leukoc Biol 62 :458–464.
-
23
Fan F-C, Chen RYZ, Schuessler GB, Chien S, 1980. Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog. Am J Physiol 238 :H545–H552.
-
24
Pries AR, Secomb TW, Gaehtgens P, 1995. Design principles of vascular beds. Circ Res 77 :1017–1025.
-
25
Dondorp AM, Angus BJ, Hardeman MR, Chotivanich KT, Silamut K, Ruangveerayuth R, Kager PA, White NJ, Vreeken J, 1997. Prognostic significance of reduced red blood cell deformability in severe falciparum malaria. Am J Trop Med Hyg 57 :507–511.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 261 | 231 | 9 |
| Full Text Views | 236 | 2 | 0 |
| PDF Downloads | 47 | 2 | 0 |