HYPERCALCEMIA IN HEPATIC TUBERCULOSIS: A CASE REPORT IN KOREA

EUN SEOK KANG Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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MI YOUNG DO Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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SO YOUNG PARK Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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KYU YEON HUR Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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CHUL WOO AHN Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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BONG SOO CHA Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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SUNG KIL LIM Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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KYUNG RAE KIM Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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HYUN CHUL LEE Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea

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Although primary hyperparathyroidism and malignant diseases account for approximately 90% of the causes of hypercalcemia, they could occur in association with granulomatous diseases such as tuberculosis or sarcoidosis, especially in developing countries. Hepatic tuberculosis is difficult to diagnosis without suspicion in cases with normal findings on chest radiographs. We report a 70-year-old woman who presented with hypercalcemia due to hepatic tuberculosis. The diagnosis was made by a computed tomography scan and laparoscopic evaluation. After treatment with anti-tuberculosis medication, her hypercalcemia resolved. Increased vitamin D synthesis by activated macrophages in the granuloma tissue is the major mechanism of hypercalcemia in tuberculosis.

Author Notes

Reprint requests: Hyun Chul Lee, Department of Internal Medicine, Yonsei University College of Medicine, 134 Shinchondong Seodaemungu, Seoul 120-752, South Korea, Telephone: 82-2-361-5425, Fax: 82-2-393-6884, E-mail: edgo@yumc.yonsei.ac.kr.
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