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DIFFERENCE IN SUSCEPTIBILITY TO MALARIA BETWEEN TWO SYMPATRIC ETHNIC GROUPS IN MALI

AMAGANA DOLOMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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DAVID MODIANOMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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BOUBACAR MAIGAMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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MODIBO DAOUMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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GUIMOGO DOLOMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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HAMADOUN GUINDOMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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MAMADOU BAMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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HAMA MAIGAMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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DRISSA COULIBALYMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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HEDVIG PERLMANMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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MARITA TROYE BLOMBERGMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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YEYA TIEMOKO TOURÉMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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MARIO COLUZZIMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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OGOBARA DOUMBOMalaria Research and Training Center, Département d’Epidémiologie des Affections Parasitaires, Faculté de Médecine, de Pharmacie et d’Odonto-Stomatologie, Bamako, Mali; Dipartimento di Scienze di Sanita Pubblica, Sezione di Parassitologia, World Health Organization Collaborating Centre for Malaria Epidemiology and Control, University of Rome Rome, Italy; Department of Immunology, Stockholm University, Stockholm, Sweden

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We compared malaria indicators among sympatric groups to study human heterogeneities in the response to Plasmodium falciparum malaria infection. Four cross-sectional surveys and two longitudinal surveys in two sympatric ethnic groups (Dogon and Fulani) in Mali were carried out from 1998 to 2000. Spleen and parasite rates were evaluated during the cross-sectional surveys and disease incidence was assessed during longitudinal surveys. In spite of similar sociocultural factors and entomologic inoculation rates between ethnic groups, the Fulani had a significantly higher spleen enlargement rate, lower parasite rate, and were less affected by the disease than the Dogon group, whose frequency of hemoglobin C was higher than that recorded among the Fulani group. The Fulani group had significantly higher levels of IgG and IgE against crude malaria antigen than the Dogon group, suggesting a role of anti-malaria antibodies in the immune protection seen in this group.

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