SPATIAL PATTERNS OF AND RISK FACTORS FOR SEROPOSITIVITY FOR DENGUE INFECTION

BIRGIT H. B. VAN BENTHEM Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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SOPHIE O. VANWAMBEKE Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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NARDLADA KHANTIKUL Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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CHANTAL BURGHOORN-MAAS Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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KAMOLWAN PANART Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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LINDA OSKAM Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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ERIC F. LAMBIN Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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PRADYA SOMBOON Koninklijk Insituut voor de Tropen/Royal Tropical Institute, Biomedical Research, Amsterdam, The Netherlands; Department of Geography, Université Catholique de Louvain, Louvain, Belgium; Office of Vector Borne Disease Control No. 2, Muang District, Chiang Mai, Thailand; Institute of Virology, Erasmus University, Rotterdam, The Netherlands; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand

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Spatial patterns of and risk factors for seropositivity of dengue infection were studied in three sites in northern Thailand. A survey was conducted in 2001 among 1,750 persons. Potential risk factors for dengue infection were measured by questionnaire and IgM antibodies against dengue were detected by an enzyme-linked immunosorbent assay. The role of landscape as a risk factor was studied using land cover maps and a geographic information system. Logistic regression identified risk factors for dengue seropositivity. Spatial patterns of seropositive cases were determined by cluster analyses. Six percent of the study population was seropositive. Risk factors for dengue seropositivity differed per site, demonstrating variation in local infection patterns. In the periurban site, seropositivity depended on human behavior and factors related to housing quality rather than environmental factors. In both rural sites, older persons had a higher risk of seropositivity and persons living in houses surrounded by natural and agricultural land covers had a lower risk of seropositivity.

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