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Petersen E, Eaton RB, 2000. Neonatal screening for congenital infection with Toxoplasma gondii. Ambroise-Thomas P, Petersen E, eds. Congenital Toxoplasmosis. Scientific Background, Clinical Management and Control. Paris: Springer-Verlag, 305–311.
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SHORT REPORT: NEONATAL SCREENING PILOT STUDY OF TOXOPLASMA GONDII CONGENITAL INFECTION IN MEXICO
Congenital toxoplasmosis is an obstetric problem in Mexico, but its actual frequency is unknown. Using a network for screening of non-infectious disorders, we performed a pilot study to determine the frequency of IgM antibodies to Toxoplasma gondii in 1,003 infants (53.1% male, mean ± SD age = 18.3 ± 13.0 days, birth weight = 3.116 ± 0.453 kg) in Mexico City from March to April 2003. Blood samples embedded in filter paper were assayed for IgM antibodies using a capture enzyme-linked immunosorbent assay and results were confirmed by Western blot. Two asymptomatic newborns, one of them premature, had IgM and IgG antibodies in a serum sample taken from both the infant and the mother and were clinically followed. Our data suggest a frequency of approximately two cases of congenital T. gondii infection per 1,000 newborns in Mexico City.