COMPARISON OF MEGLUMINE ANTIMONIATE AND PENTAMIDINE FOR PERUVIAN CUTANEOUS LEISHMANIASIS

ELLEN M. ANDERSEN Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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MARIA CRUZ-SALDARRIAGA Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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ALEJANDRO LLANOS-CUENTAS Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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MARIA LUZ-CJUNO Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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JUAN ECHEVARRIA Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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CESAR MIRANDA-VERASTEGUI Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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OLGA COLINA Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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JONATHAN D. BERMAN Navy Environmental and Preventive Medicine Unit No. 5, San Diego, California; Hospital Instituto Peruano Seguro Social, Cusco, Peru; Universidad Peruana Cayetano Heredia; Lima, Peru; National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland

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Pentamidine was compared with meglumine antimoniate (Glucantime) for 80 patients with cutaneous leishmaniasis due to Leishmania braziliensis in Peru. Of the 40 patients administered Glucantime (20 mg of antimony [Sb]/kg/day intravenously for 20 days), 31 cured (78%), 6 failed (15%), of which 5 were due to relapse, and 3 were lost to follow-up (7%). Of the 40 patients administered pentamidine (2 mg/kg every other day for seven injections), 14 were cured (35%), 23 failed (58%), and 3 were lost to follow-up (7%). Five pentamidine failures were due to relapse, and 14 failures were due to the presence of parasites two weeks after therapy. Both regimens were well tolerated. Gastrointestinal, musculoskeletal, and total adverse events were not statistically different in either group. Elevations in levels of liver enzymes and pancreatic enzymes were statistically higher in the Glucantime group, but no patient terminated therapy prematurely. In this study, Glucantime was more effective than pentamidine for treatment of L. braziliensis cutaneous leishmaniasis in Peru based on parasitologic as well as clinical criteria.

Author Notes

Reprint requests: Ellen M. Andersen, Navy Environmental and Preventive Medicine Unit No. 5, Naval Station, 3235 Albacore Alley, San Diego, CA 92136, E-mail: eandersen@nepmu5.med.navy.mil.
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