HANTAVIRUS PULMONARY SYNDROME IN CENTRAL BOLIVIA: RELATIONSHIPS BETWEEN RESERVOIR HOSTS, HABITATS, AND VIRAL GENOTYPES

DARIN S. CARROLL Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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JAMES N. MILLS Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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JOEL M. MONTGOMERY Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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DANIEL G. BAUSCH Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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PATRICK J. BLAIR Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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JAMES P. BURANS Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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VIDAL FELICES Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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ALBERTO GIANELLA Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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NAOMI IIHOSHI Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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STUART T. NICHOL Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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JAMES G. OLSON Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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DUKE S. ROGERS Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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MILAGROS SALAZAR Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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THOMAS G. KSIAZEK Division of Viral and Rickettsial Diseases, Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia; Tulane School of Public Health and Tropical Medicine, New Orleans, Louisiana; Naval Medical Research Center Detachment, U.S. Navy, Lima, Peru; National Center for Tropical Diseases, Santa Cruz, Bolivia; Department of Integrative Biology and M. L. Bean Life Science Museum, Brigham Young University, Provo, Utah

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In August 2002, two cases of hantavirus pulmonary syndrome (HPS) were confirmed in Mineros and Concepción, within the Santa Cruz Department of Bolivia. Extensive alteration of the native ecosystem, from dense forest to pasture or sugarcane, had occurred in both regions. An ecologic assessment of reservoir species associated with the human disease identified a single hantavirus antibody-positive Oligoryzomys microtis from Mineros and three hantavirus antibody-positive Calomys callosus from Concepción. In Mineros, the virus from the O. microtis was 90% similar to sequences published for Río Mamoré virus. Viral nucleotide sequences from two C. callosus were 87–88% similar to the sequence of Laguna Negra virus. The viral sequence from the C. callosus was 99% identical to viral sequences obtained from the HPS patient in this area, implicating C. callosus as the host and Laguna Negra virus as the agent responsible for the HPS case near Concepción.

Author Notes

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