Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G, 1986. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am J Trop Med Hyg 35 :793–802.
Buchanan RD, Fine DP, Colley DG, 1973. Schistosoma mansoni: infection in mice depleted of thymus-dependent lymphocytes. II. Pathology: Altered pathogenesis. Am J Pathol 71 :208–218.
Lucas S, Musallam R, Bain J, Hassounah O, Bickle Q, Doenhoff M, 1980. The pathological effects of immunosuppression of Schistosoma mansoni-infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with antithymocyte serum, and treatment with hydrocortisone acetate. Trans R Soc Trop Med Hyg 74 :633–643.
Karanja DMS, Colley DG, Nahlen BL, Ouma JH, Secor WE, 1997. Studies on schistosomiasis in western Kenya. I. Evidence for immune-facilitated excretion of schistosome eggs from patients with Schistosoma mansoni and human immunodeficiency virus co-infections. Am J Trop Med Hyg 56 :515–521.
Richter J, Hatz C, Campagne G, Bergquist NR, Jenkins JM, 2000. Ultrasound in Schistosomiasis: A Practical Guide to the Standardized Use of Ultrasonography for the Assessment of Schistosomiasis-Related Morbidity. Geneva: World Health Organization. (http://www.who.int/tdr/publications/publications/pdf/ultrasound.pdf).
Colley DG, Katz N, Rocha RS, Abrantes W, da Silva AL, Gazzinelli G, 1983. Immune responses during human schistosomiasis mansoni. IX. T-lymphocyte subset analysis by mono-clonal antibodies in hepatosplenic disease. Scand J Immunol 17 :297–302.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1428 | 1346 | 118 |
| Full Text Views | 265 | 7 | 0 |
| PDF Downloads | 66 | 13 | 5 |
To investigate whether infection with human immunodeficiency virus 1 (HIV-1) affects fibrosis development in patients infected with Schistosoma mansoni, we evaluated schistosomiasis-induced pathology in the livers of Kenyan patients co-infected with HIV-1. Compared with persons with schistosomiasis alone (n = 58), there were no significant differences in distribution of ultrasound-detectable pathology in persons with HIV-1 co-infection (n = 23). Similarly, serum aspartate aminotransferase levels were not significantly different in HIV-1+ individuals. Hepatic fibrosis was associated with significantly decreased CD4+ T cell counts, even in the absence of HIV-1 infection. These data suggest that HIV-1 co-infection does not significantly alter the proportion of patients experiencing schistosomiasis-induced fibrosis, but pathology associated with S. mansoni infections leads to CD4+ T cell reductions and thereby may exacerbate the effects of HIV-1 in co-infected individuals.
Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G, 1986. Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am J Trop Med Hyg 35 :793–802.
Buchanan RD, Fine DP, Colley DG, 1973. Schistosoma mansoni: infection in mice depleted of thymus-dependent lymphocytes. II. Pathology: Altered pathogenesis. Am J Pathol 71 :208–218.
Lucas S, Musallam R, Bain J, Hassounah O, Bickle Q, Doenhoff M, 1980. The pathological effects of immunosuppression of Schistosoma mansoni-infected mice, with particular reference to survival and hepatotoxicity after thymectomy and treatment with antithymocyte serum, and treatment with hydrocortisone acetate. Trans R Soc Trop Med Hyg 74 :633–643.
Karanja DMS, Colley DG, Nahlen BL, Ouma JH, Secor WE, 1997. Studies on schistosomiasis in western Kenya. I. Evidence for immune-facilitated excretion of schistosome eggs from patients with Schistosoma mansoni and human immunodeficiency virus co-infections. Am J Trop Med Hyg 56 :515–521.
Richter J, Hatz C, Campagne G, Bergquist NR, Jenkins JM, 2000. Ultrasound in Schistosomiasis: A Practical Guide to the Standardized Use of Ultrasonography for the Assessment of Schistosomiasis-Related Morbidity. Geneva: World Health Organization. (http://www.who.int/tdr/publications/publications/pdf/ultrasound.pdf).
Colley DG, Katz N, Rocha RS, Abrantes W, da Silva AL, Gazzinelli G, 1983. Immune responses during human schistosomiasis mansoni. IX. T-lymphocyte subset analysis by mono-clonal antibodies in hepatosplenic disease. Scand J Immunol 17 :297–302.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1428 | 1346 | 118 |
| Full Text Views | 265 | 7 | 0 |
| PDF Downloads | 66 | 13 | 5 |
