Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael AJ, Greenwood BM, 1991. Common west African HLA antigens are associated with protection from severe malaria. Nature 352 :595–600.
McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiat-kowski D, 1994. Variation in the TNF-α promoter region is associated with susceptibility to cerebral malaria. Nature 371 :508–511.
Meyer CG, May J, Luty AJ, Lell B, Kremsner PG, 2002. TNFα-308 is associated with shorter intervals of Plasmodium falciparum reinfections. Tissue Antigens 59 :287–292.
Hobbs MR, Udhayakumar V, Levesque MC, Booth J, Roberts JM, Tkachuk AN, Pole A, Coon H, Kariuki S, Nahlen BL, Mwaikambo ED, Lal AL, Granger DL, Anstey NM, Weinberg JB, 2002. A new NOS2 promoter polymorphism associated with increased NO production and protection from severe malaria in Tanzanian and Kenyan children. Lancet 360 :1468–1475.
Knight JC, Udalova I, Hill AV, Greenwood BM, Peshu N, Marsh K, Kwiatkowski D, 1999. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet 22 :145–150.
Dorsey G, Njama D, Kamya MR, Staedke SG, Gasasira A, Rosenthal PJ, 2002. Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet 360 :2031–2038.
Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G, 2003. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of MSP-1, MSP-2, and GLURP. Am J Trop Med Hyg 68 :133–139.
Ruwende C, Hill A, 1998. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med 76 :581–588.
Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G, 2003. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg 69 :244–246.
Njama D, Dorsey G, Guwatudde D, Kigonya K, Greenhouse B, Musisi S, Kamya MR, 2003. Urban malaria: primary caregivers’ knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children. Trop Med Int Health 8 :685–692.
Ruwende C, Khoo SC, Snow RW, Yates SN, Kwiatkowski D, Gupta S, Warn P, Allsopp CE, Gilbert SC, Peschu N, 1995. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 376 :246–249.
Migot-Nabias F, Mombo LE, Luty AJ, Dubois B, Nabias R, Bisseye C, Millet P, Lu CY, Deloron P, 2000. Human genetic factors in relation to susceptibility to mild malaria in Gabon. Genes Immun 1 :435–441.
Lell B, May J, Schmidt-Ott RJ, Lehman LG, Luckner D, Greve B, Matousek P, Schmid D, Herbich K, Mockenhaupt FP, Meyer CG, Bienzle U, Kremsner PG, 1999. The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin Infect Dis 28 :794–799.
Roth EF, Raventos-Suarez C, Rinaldi A, Nagel RL, 1983. Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum. Proc Natl Acad Sci USA 80 :298.
Williams TN, Maitland K, Bennett S, Ganczakowski M, Peto TE, Newbold CI, Bowden DK, Weatherall DJ, Clegg JB, 1996. High incidence of malaria in α-thalassemic children. Nature 383 :522–525.
Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, Misukonis MA, Arnell DR, Hollis D, McDonald MI, Granger DL, 1996. Nitric oxide in Tanzanian children with malaria: inverse relationship with between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 184 :557–567.
Kun JF, Mordmuller B, Perkins DJ, May J, Mercereau-Puijalon O, Alpers MP, Weinberg JB, Kremsner PG, 2001. Nitric oxide synthase 2Lambarene (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis 184 :330–336.
Coulibaly FH, Koffi G, Toure HA, Bouanga JC, Allangba O, Tolo A, Swandogo D, Sanogo I, Konate S, Prehu C, Sangare A, Galacteros F, 2000. Molecular genetics of glucose-6-phosphate dehydrogenase deficiency in a population of newborns from Ivory Coast. Clin Biochem 33 :411–413.
Mombo LE, Ntoumi F, Bisseye C, Ossari S, Lu CY, Nagel RL, Krishnamoorthy R, 2003. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Am J Trop Med Hyg 68 :186–190.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 338 | 281 | 10 |
| Full Text Views | 257 | 9 | 2 |
| PDF Downloads | 67 | 14 | 4 |
Mutations in β-globin, glucose-6-phosphate dehydrogenase, and promoters for tumor necrosis factor-α and inducible nitric oxide synthase (iNOS) were examined for associations with the incidence of symptomatic malaria in a cohort of 307 Ugandan children. After adjustment of incidence rates for age, water source, use of preventative measures, and proximity to mosquito breeding sites, glucose-6-phosphate dehydrogenase A- heterozygous females had a significantly higher incidence of malaria (incidence rate ratio [IRR] = 1.63, P = 0.03) and a trend towards higher parasite densities (37,100 versus 26,200 parasites/μL; P = 0.18) compared with wild-type children. Male hemizygotes had trends in the same direction. Heterozygotes for sickle hemoglobin had trends toward a lower incidence of malaria and lower parasite density at presentation. Heterozygotes for the iNOS promoter G954C polymorphism, but not other promoter polymorphisms, had a significantly lower incidence of malaria compared with wild-type children (IRR = 0.69, P = 0.05). Host polymorphisms appear to impact upon the incidence of uncomplicated malaria in Ugandan children.
Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Twumasi P, Rowe PA, Bennett S, Brewster D, McMichael AJ, Greenwood BM, 1991. Common west African HLA antigens are associated with protection from severe malaria. Nature 352 :595–600.
McGuire W, Hill AV, Allsopp CE, Greenwood BM, Kwiat-kowski D, 1994. Variation in the TNF-α promoter region is associated with susceptibility to cerebral malaria. Nature 371 :508–511.
Meyer CG, May J, Luty AJ, Lell B, Kremsner PG, 2002. TNFα-308 is associated with shorter intervals of Plasmodium falciparum reinfections. Tissue Antigens 59 :287–292.
Hobbs MR, Udhayakumar V, Levesque MC, Booth J, Roberts JM, Tkachuk AN, Pole A, Coon H, Kariuki S, Nahlen BL, Mwaikambo ED, Lal AL, Granger DL, Anstey NM, Weinberg JB, 2002. A new NOS2 promoter polymorphism associated with increased NO production and protection from severe malaria in Tanzanian and Kenyan children. Lancet 360 :1468–1475.
Knight JC, Udalova I, Hill AV, Greenwood BM, Peshu N, Marsh K, Kwiatkowski D, 1999. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet 22 :145–150.
Dorsey G, Njama D, Kamya MR, Staedke SG, Gasasira A, Rosenthal PJ, 2002. Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet 360 :2031–2038.
Cattamanchi A, Kyabayinze D, Hubbard A, Rosenthal PJ, Dorsey G, 2003. Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of MSP-1, MSP-2, and GLURP. Am J Trop Med Hyg 68 :133–139.
Ruwende C, Hill A, 1998. Glucose-6-phosphate dehydrogenase deficiency and malaria. J Mol Med 76 :581–588.
Staedke SG, Nottingham EW, Cox J, Kamya MR, Rosenthal PJ, Dorsey G, 2003. Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg 69 :244–246.
Njama D, Dorsey G, Guwatudde D, Kigonya K, Greenhouse B, Musisi S, Kamya MR, 2003. Urban malaria: primary caregivers’ knowledge, attitudes, practices and predictors of malaria incidence in a cohort of Ugandan children. Trop Med Int Health 8 :685–692.
Ruwende C, Khoo SC, Snow RW, Yates SN, Kwiatkowski D, Gupta S, Warn P, Allsopp CE, Gilbert SC, Peschu N, 1995. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature 376 :246–249.
Migot-Nabias F, Mombo LE, Luty AJ, Dubois B, Nabias R, Bisseye C, Millet P, Lu CY, Deloron P, 2000. Human genetic factors in relation to susceptibility to mild malaria in Gabon. Genes Immun 1 :435–441.
Lell B, May J, Schmidt-Ott RJ, Lehman LG, Luckner D, Greve B, Matousek P, Schmid D, Herbich K, Mockenhaupt FP, Meyer CG, Bienzle U, Kremsner PG, 1999. The role of red blood cell polymorphisms in resistance and susceptibility to malaria. Clin Infect Dis 28 :794–799.
Roth EF, Raventos-Suarez C, Rinaldi A, Nagel RL, 1983. Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum. Proc Natl Acad Sci USA 80 :298.
Williams TN, Maitland K, Bennett S, Ganczakowski M, Peto TE, Newbold CI, Bowden DK, Weatherall DJ, Clegg JB, 1996. High incidence of malaria in α-thalassemic children. Nature 383 :522–525.
Anstey NM, Weinberg JB, Hassanali MY, Mwaikambo ED, Manyenga D, Misukonis MA, Arnell DR, Hollis D, McDonald MI, Granger DL, 1996. Nitric oxide in Tanzanian children with malaria: inverse relationship with between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. J Exp Med 184 :557–567.
Kun JF, Mordmuller B, Perkins DJ, May J, Mercereau-Puijalon O, Alpers MP, Weinberg JB, Kremsner PG, 2001. Nitric oxide synthase 2Lambarene (G-954C), increased nitric oxide production, and protection against malaria. J Infect Dis 184 :330–336.
Coulibaly FH, Koffi G, Toure HA, Bouanga JC, Allangba O, Tolo A, Swandogo D, Sanogo I, Konate S, Prehu C, Sangare A, Galacteros F, 2000. Molecular genetics of glucose-6-phosphate dehydrogenase deficiency in a population of newborns from Ivory Coast. Clin Biochem 33 :411–413.
Mombo LE, Ntoumi F, Bisseye C, Ossari S, Lu CY, Nagel RL, Krishnamoorthy R, 2003. Human genetic polymorphisms and asymptomatic Plasmodium falciparum malaria in Gabonese schoolchildren. Am J Trop Med Hyg 68 :186–190.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 338 | 281 | 10 |
| Full Text Views | 257 | 9 | 2 |
| PDF Downloads | 67 | 14 | 4 |
