RISK FACTORS FOR PLASMODIUM VIVAX GAMETOCYTE CARRIAGE IN THAILAND

MATHIEU NACHER Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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UDOMSAK SILACHAMROON Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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PRATAP SINGHASIVANON Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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POLRAT WILAIRATANA Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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WEERAPONG PHUMRATANAPRAPIN Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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ARNAUD FONTANET Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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SORNCHAI LOOAREESUWAN Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand; Unité d’Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France

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DOI:
https://doi.org/10.4269/ajtmh.2004.71.693
Volume/Issue:
Volume 71: Issue 6
Page(s):
693–695
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To study the risk factors for Plasmodium vivax gametocyte carriage, the presence or absence of gametocytes was determined in 2,125 patients with P. vivax malaria participating in clinical trials at the Hospital for Tropical Diseases in Bangkok, Thailand. Stepwise logistic regression models were used to determine which variables were significantly related to gametocyte carriage. On admission, 615 patients (29%) had detectable gametocytes (before treatment). After treatment had started, an additional 245 patients (11%) developed patent gametocytemia. The variables retained by multivariate analysis were highest observed temperature (adjusted odds ratio [AOR] per °C increase = 0.82, 95% confidence interval [CI] = 0.71–0.94, P = 0.006), asexual parasitemia > 9,200/μL (AOR = 2.8, 95% CI = 1.9–4.2, P < 0.0001), erythrocyte counts (AOR = 0.8/million/μL increase, 95% CI = 0.67–0.95, P = 0.01), monocyte percentage (AOR = 0.93 per % increase, 95% CI = 0.89–0.96, P < 0.0001), lymphocyte percentage (AOR = 0.98 per % increase, 95% CI = 0.97–0.99, P = 0.006), albumin (AOR = 0.67 per 10 g/mL increase, 95% CI = 0.5–0.9, P = 0.007), and anion gap (AOR = 1.1 per unit increase, 95% CI = 1.02–1.14, P = 0.009). The possible significance of these observations is discussed.

Author Notes

Copyright:
Copyright 2004 The American Society of Tropical Medicine 2004
Received:
29 Oct 2003
|
Accepted:
08 Jan 2004
|
Published Online:
Dec 2004
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
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